Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse

To investigate the effects of Rho GTPase inactivation on lens fiber cell cytoskeletal and morphological integrity, a transgenic mouse model expressing C3-exoenzyme (a bacterial toxin) in a lens-specific manner was utilized. Cryosections of whole eyes from C3 transgenic mice and littermate controls w...

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Veröffentlicht in:	Laboratory investigation 2004-06, Vol.84 (6), p.679-692
Hauptverfasser:	Maddala, Rupalatha, Deng, Pei-Feng, Costello, Joseph M, Wawrousek, Eric F, Zigler, Jacob S, Rao, Vasantha P
Format:	Artikel
Sprache:	eng
Schlagworte:	actin cytoskeleton Actins - metabolism Animals Aquaporins - metabolism Base Sequence Biological and medical sciences Biotechnology C3-exoenzyme cell junctions Connexins - metabolism Cytoskeletal Proteins - metabolism Cytoskeleton - enzymology Cytoskeleton - metabolism Cytoskeleton - pathology DNA - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lens, Crystalline - enzymology Lens, Crystalline - metabolism Lens, Crystalline - pathology Male Medical sciences Medicine Medicine & Public Health Mice Mice, Knockout Mice, Transgenic microarray Microscopy, Electron Oligonucleotide Array Sequence Analysis Pathology research-article Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - deficiency rho GTP-Binding Proteins - genetics Rho GTPases transgenic lens
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