Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6 mice after oral dosing of a disodium disuccinate diester of astaxanthin ( Heptax™)

Oral bioavailability of natural and synthetic carotenoids is generally poor in rodents, and this has limited the ability to test these antioxidant compounds in well-defined rodent models of human disease. Various strategies have been employed, with variable success, to increase the percentage of the...

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Veröffentlicht in:	Comparative biochemistry and physiology. Toxicology & pharmacology 2004-03, Vol.137 (3), p.227-236
Hauptverfasser:	Showalter, Lori A., Weinman, Steven A., Østerlie, Marianne, Lockwood, Samuel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Area Under Curve Astaxanthin beta Carotene - administration & dosage beta Carotene - analogs & derivatives beta Carotene - blood beta Carotene - chemistry beta Carotene - pharmacokinetics C57BL/6 mice Carotenoid bioavailability Carotenoid derivatives Chromatography, High Pressure Liquid Emulsions Hepatoprotection Heptax Male Mice Mice, Inbred C3H Oral gavage Oxidative stress Single-dose oral pharmacokinetics Stereoisomerism Succinates - administration & dosage Succinates - chemistry Succinates - pharmacokinetics Tissue Distribution Xanthophylls
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