Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells

The activation of the microvascular endothelial cell platelet-derived growth factor (PDGF) receptor (PDGF-R) by PDGF has been implicated in neoplastic angiogenesis. Here, we established cultures of murine bone microvascular endothelial cells and examined their response to stimulation with PDGF BB li...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-06, Vol.64 (11), p.3727-3730
Hauptverfasser:	LANGLEY, Robert R, FAN, Dominic, TSAN, Rachel Z, REBHUN, Robert, HE, Junqin, KIM, Sun-Jin, FIDLER, Isaiah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Benzamides Biological and medical sciences Bone and Bones - cytology Bone and Bones - drug effects Bone and Bones - enzymology Cell Survival - drug effects Cell Survival - physiology Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - enzymology Enzyme Inhibitors - pharmacology Female Imatinib Mesylate Immunohistochemistry Male Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Paclitaxel - pharmacology Pharmacology. Drug treatments Phosphorylation Piperazines - pharmacology Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-sis Pyrimidines - pharmacology Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors Receptor, Platelet-Derived Growth Factor beta - metabolism Receptor, Platelet-Derived Growth Factor beta - physiology Tumors
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