Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors

Background Enhanced oxidative stress has been observed in hypertension, but the underlying mechanism has not been fully clarified.Objective To study the relationship between oxygen free radicals and hypertension, using platelets as a tool to measure the cellular production of superoxide anion (O2).D...

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Veröffentlicht in:	Journal of hypertension 2004-06, Vol.22 (6), p.1151-1156
Hauptverfasser:	Germanò, Giuseppe, Sanguigni, Valerio, Pignatelli, Pasquale, Caccese, Daniela, Lenti, Luisa, Ragazzo, Maddalena, Lauro, Renato, Violi, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Blood Platelets - metabolism Case-Control Studies Diuretics Female Humans Hydrochlorothiazide - therapeutic use Hypertension - blood Hypertension - drug therapy Irbesartan Male Middle Aged NADPH Oxidases - metabolism Receptor, Angiotensin, Type 1 - drug effects Sodium Chloride Symporter Inhibitors - therapeutic use Superoxides - blood Tetrazoles - pharmacology Tetrazoles - therapeutic use
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