The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design. We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP...
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| Veröffentlicht in: | American journal of hypertension 2002-08, Vol.15 (8), p.691-696 |
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| container_title | American journal of hypertension |
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| creator | Jee, Sun H.a Miller, Edgar R Guallar, Eliseo Singh, Vikesh K Appel, Lawrence J Klag, Michael J |
| description | An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design.
We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose–response relationship of magnesium to BP.
The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were −0.6 (−2.2 to 1.0) mm Hg for systolic BP and −0.8 (−1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2;
P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0;
P = .09) for each 10 mmol/day increase in magnesium dose.
Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship. |
| doi_str_mv | 10.1016/S0895-7061(02)02964-3 |
| format | Article |
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We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose–response relationship of magnesium to BP.
The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were −0.6 (−2.2 to 1.0) mm Hg for systolic BP and −0.8 (−1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2;
P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0;
P = .09) for each 10 mmol/day increase in magnesium dose.
Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/S0895-7061(02)02964-3</identifier><identifier>PMID: 12160191</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; blood pressure ; Blood Pressure - drug effects ; Confidence Intervals ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; General and cellular metabolism. Vitamins ; Humans ; Hypertension - prevention & control ; Magnesium - administration & dosage ; magnesium supplements ; Male ; Medical sciences ; Meta-analysis ; Middle Aged ; Pharmacology. Drug treatments ; Randomized Controlled Trials as Topic</subject><ispartof>American journal of hypertension, 2002-08, Vol.15 (8), p.691-696</ispartof><rights>2002 American Journal of Hypertension, Ltd.</rights><rights>American Journal of Hypertension, Ltd. © 2002 by the American Journal of Hypertension, Ltd. 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-e16e74491e00a3a6c5c5d642446a011718152c3921539c006f9405a39cabb1ae3</citedby><cites>FETCH-LOGICAL-c564t-e16e74491e00a3a6c5c5d642446a011718152c3921539c006f9405a39cabb1ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13823442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12160191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jee, Sun H.a</creatorcontrib><creatorcontrib>Miller, Edgar R</creatorcontrib><creatorcontrib>Guallar, Eliseo</creatorcontrib><creatorcontrib>Singh, Vikesh K</creatorcontrib><creatorcontrib>Appel, Lawrence J</creatorcontrib><creatorcontrib>Klag, Michael J</creatorcontrib><title>The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design.
We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose–response relationship of magnesium to BP.
The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were −0.6 (−2.2 to 1.0) mm Hg for systolic BP and −0.8 (−1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2;
P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0;
P = .09) for each 10 mmol/day increase in magnesium dose.
Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Confidence Intervals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Hypertension - prevention & control</subject><subject>Magnesium - administration & dosage</subject><subject>magnesium supplements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Vitamins</topic><topic>Humans</topic><topic>Hypertension - prevention & control</topic><topic>Magnesium - administration & dosage</topic><topic>magnesium supplements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jee, Sun H.a</creatorcontrib><creatorcontrib>Miller, Edgar R</creatorcontrib><creatorcontrib>Guallar, Eliseo</creatorcontrib><creatorcontrib>Singh, Vikesh K</creatorcontrib><creatorcontrib>Appel, Lawrence J</creatorcontrib><creatorcontrib>Klag, Michael J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jee, Sun H.a</au><au>Miller, Edgar R</au><au>Guallar, Eliseo</au><au>Singh, Vikesh K</au><au>Appel, Lawrence J</au><au>Klag, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>15</volume><issue>8</issue><spage>691</spage><epage>696</epage><pages>691-696</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design.
We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose–response relationship of magnesium to BP.
The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were −0.6 (−2.2 to 1.0) mm Hg for systolic BP and −0.8 (−1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2;
P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0;
P = .09) for each 10 mmol/day increase in magnesium dose.
Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12160191</pmid><doi>10.1016/S0895-7061(02)02964-3</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2002-08, Vol.15 (8), p.691-696 |
| issn | 0895-7061 1879-1905 1941-7225 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Analysis of Variance Biological and medical sciences blood pressure Blood Pressure - drug effects Confidence Intervals Dose-Response Relationship, Drug Double-Blind Method Female General and cellular metabolism. Vitamins Humans Hypertension - prevention & control Magnesium - administration & dosage magnesium supplements Male Medical sciences Meta-analysis Middle Aged Pharmacology. Drug treatments Randomized Controlled Trials as Topic |
| title | The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials |
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