Simultaneous micellar liquid chromatographic analysis of seven water-soluble vitamins: optimization using super-modified simplex
A super-modified simplex (SMS) method has been used to optimize the mobile phase used for separation of seven water-soluble vitamins in multivitamin tablets by gradient micellar liquid chromatography (MLC) with ultraviolet (UV) detection at 254, 295, and 361 nm. Effect of column temperature and addi...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2004-06, Vol.379 (3), p.439-444 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Ghorbani, Ali R Momenbeik, Fariborz Khorasani, Jafar H Amini, Mohammad K |
| description | A super-modified simplex (SMS) method has been used to optimize the mobile phase used for separation of seven water-soluble vitamins in multivitamin tablets by gradient micellar liquid chromatography (MLC) with ultraviolet (UV) detection at 254, 295, and 361 nm. Effect of column temperature and addition of organic modifier to the mobile phase on separation efficiency were investigated: the appropriate conditions used were a temperature of 35 degrees C and 1-butanol modifier. The sodium dodecyl sulfate (SDS) concentration, pH, and 1-butanol% in the mobile phase were chosen for simultaneous optimization using the SMS method. The optimum mobile phase was found to be 16 mmol L(-1) (mM) SDS, 0.02 M phosphate buffer, pH 3.6, and a gradient of 3.5-10% (v/v) butanol. The total analysis time for vitamins was 75 min. The analytical parameters including linearity ( r>0.9970), limit of detection (0.12-50 micro g mL(-1)), precision of method (relative standard deviation (RSD) |
| doi_str_mv | 10.1007/s00216-004-2594-1 |
| format | Article |
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Effect of column temperature and addition of organic modifier to the mobile phase on separation efficiency were investigated: the appropriate conditions used were a temperature of 35 degrees C and 1-butanol modifier. The sodium dodecyl sulfate (SDS) concentration, pH, and 1-butanol% in the mobile phase were chosen for simultaneous optimization using the SMS method. The optimum mobile phase was found to be 16 mmol L(-1) (mM) SDS, 0.02 M phosphate buffer, pH 3.6, and a gradient of 3.5-10% (v/v) butanol. The total analysis time for vitamins was 75 min. The analytical parameters including linearity ( r>0.9970), limit of detection (0.12-50 micro g mL(-1)), precision of method (relative standard deviation (RSD) <8.90%), and accuracy obtained by the recovery assay (88-103%) support the usefulness of the proposed method for the determination of the water-soluble vitamins.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-004-2594-1</identifier><identifier>PMID: 15067492</identifier><language>eng</language><publisher>Germany</publisher><subject>Ascorbic Acid - analysis ; Chromatography, Liquid - methods ; Hydrogen-Ion Concentration ; Indicators and Reagents - chemistry ; Reproducibility of Results ; Sensitivity and Specificity ; Solubility ; Temperature ; Vitamin B Complex - analysis ; Water</subject><ispartof>Analytical and bioanalytical chemistry, 2004-06, Vol.379 (3), p.439-444</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-44e64703f21a249e03ae6400709df8a941d7190d11c828f16b5074a9741596783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15067492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorbani, Ali R</creatorcontrib><creatorcontrib>Momenbeik, Fariborz</creatorcontrib><creatorcontrib>Khorasani, Jafar H</creatorcontrib><creatorcontrib>Amini, Mohammad K</creatorcontrib><title>Simultaneous micellar liquid chromatographic analysis of seven water-soluble vitamins: optimization using super-modified simplex</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><description>A super-modified simplex (SMS) method has been used to optimize the mobile phase used for separation of seven water-soluble vitamins in multivitamin tablets by gradient micellar liquid chromatography (MLC) with ultraviolet (UV) detection at 254, 295, and 361 nm. 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The analytical parameters including linearity ( r>0.9970), limit of detection (0.12-50 micro g mL(-1)), precision of method (relative standard deviation (RSD) <8.90%), and accuracy obtained by the recovery assay (88-103%) support the usefulness of the proposed method for the determination of the water-soluble vitamins.</abstract><cop>Germany</cop><pmid>15067492</pmid><doi>10.1007/s00216-004-2594-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Ascorbic Acid - analysis Chromatography, Liquid - methods Hydrogen-Ion Concentration Indicators and Reagents - chemistry Reproducibility of Results Sensitivity and Specificity Solubility Temperature Vitamin B Complex - analysis Water |
| title | Simultaneous micellar liquid chromatographic analysis of seven water-soluble vitamins: optimization using super-modified simplex |
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