In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi
Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described p...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2004-06, Vol.53 (6), p.1086-1089 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Garcia-Effron, Guillermo Gomez-Lopez, Alicia Mellado, Emilia Monzon, Araceli Rodriguez-Tudela, Juan L. Cuenca-Estrella, Manuel |
| description | Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs |
| doi_str_mv | 10.1093/jac/dkh228 |
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Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs ≥ 4 mg/L. Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkh228</identifier><identifier>PMID: 15102749</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acremonium ; allylamines ; Amphotericin B - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal Agents - pharmacology ; antifungals ; Aspergillus spp ; Biological and medical sciences ; Fungi - drug effects ; Fusarium ; Itraconazole - pharmacology ; Medical sciences ; Microbial Sensitivity Tests ; Mucorales ; Naphthalenes - pharmacology ; Paecilomyces ; Penicillium ; Pharmacology. Drug treatments ; Pyrimidines - pharmacology ; Scedosporium ; Scopulariopsis brevicaulis ; Spain ; Spanish filamentous fungi ; Triazoles - pharmacology ; Trichoderma ; Voriconazole</subject><ispartof>Journal of antimicrobial chemotherapy, 2004-06, Vol.53 (6), p.1086-1089</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-6df12964f37a4d77c8ceaa8e58961cbfb9d349092e5536a5493e70af385a90b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15880188$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15102749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Effron, Guillermo</creatorcontrib><creatorcontrib>Gomez-Lopez, Alicia</creatorcontrib><creatorcontrib>Mellado, Emilia</creatorcontrib><creatorcontrib>Monzon, Araceli</creatorcontrib><creatorcontrib>Rodriguez-Tudela, Juan L.</creatorcontrib><creatorcontrib>Cuenca-Estrella, Manuel</creatorcontrib><title>In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs ≥ 4 mg/L. Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.</description><subject>Acremonium</subject><subject>allylamines</subject><subject>Amphotericin B - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>antifungals</subject><subject>Aspergillus spp</subject><subject>Biological and medical sciences</subject><subject>Fungi - drug effects</subject><subject>Fusarium</subject><subject>Itraconazole - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Mucorales</subject><subject>Naphthalenes - pharmacology</subject><subject>Paecilomyces</subject><subject>Penicillium</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidines - pharmacology</subject><subject>Scedosporium</subject><subject>Scopulariopsis brevicaulis</subject><subject>Spain</subject><subject>Spanish filamentous fungi</subject><subject>Triazoles - pharmacology</subject><subject>Trichoderma</subject><subject>Voriconazole</subject><issn>0305-7453</issn><issn>1460-2091</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFrFDEYBuAgit1WL_4ACYI9CGOTySSZHGVpbaHUgwriJXyTSdpsZzLTJFO6_94su6h48ZQP8vCSfC9Cbyj5SIliZxswZ_39XV23z9CKNoJUNVH0OVoRRnglG86O0HFKG0KI4KJ9iY4op6SWjVqhzVXAjz7HCYPJvkxbPDmcbex8AOeDxXALPqSMR9t7A8OwxX6cp5ghZBymUPU2jpCn-W6bLU6zNd6mXYbzA4w25GlJ2C3h1r9CLxwMyb4-nCfo-8X5t_Vldf3l89X603VlmobnSvSO1ko0jkloeilNayxAa3mrBDWd61TPGkVUbTlnAnijmJUEHGs5KNIxdoJO97lznB4Wm7IefTJ2GCDY8hgtqeKKEfpfWBOqZE1Ege_-gZtpiaF8QtdUCkkY4wV92CMTp5SidXqOfoS41ZToXU-69KT3PRX89pC4dGWxf-ihmALeHwCksnUXIRif_nJtS2i7C6r2zqdsn37fQ7zXQjLJ9eWPn_rm641aSyE0Z78AKvKrvw</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Garcia-Effron, Guillermo</creator><creator>Gomez-Lopez, Alicia</creator><creator>Mellado, Emilia</creator><creator>Monzon, Araceli</creator><creator>Rodriguez-Tudela, Juan L.</creator><creator>Cuenca-Estrella, Manuel</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi</title><author>Garcia-Effron, Guillermo ; Gomez-Lopez, Alicia ; Mellado, Emilia ; Monzon, Araceli ; Rodriguez-Tudela, Juan L. ; Cuenca-Estrella, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-6df12964f37a4d77c8ceaa8e58961cbfb9d349092e5536a5493e70af385a90b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acremonium</topic><topic>allylamines</topic><topic>Amphotericin B - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>antifungals</topic><topic>Aspergillus spp</topic><topic>Biological and medical sciences</topic><topic>Fungi - drug effects</topic><topic>Fusarium</topic><topic>Itraconazole - pharmacology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Mucorales</topic><topic>Naphthalenes - pharmacology</topic><topic>Paecilomyces</topic><topic>Penicillium</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidines - pharmacology</topic><topic>Scedosporium</topic><topic>Scopulariopsis brevicaulis</topic><topic>Spain</topic><topic>Spanish filamentous fungi</topic><topic>Triazoles - pharmacology</topic><topic>Trichoderma</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Effron, Guillermo</creatorcontrib><creatorcontrib>Gomez-Lopez, Alicia</creatorcontrib><creatorcontrib>Mellado, Emilia</creatorcontrib><creatorcontrib>Monzon, Araceli</creatorcontrib><creatorcontrib>Rodriguez-Tudela, Juan L.</creatorcontrib><creatorcontrib>Cuenca-Estrella, Manuel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Effron, Guillermo</au><au>Gomez-Lopez, Alicia</au><au>Mellado, Emilia</au><au>Monzon, Araceli</au><au>Rodriguez-Tudela, Juan L.</au><au>Cuenca-Estrella, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J. Antimicrob. Chemother</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>53</volume><issue>6</issue><spage>1086</spage><epage>1089</epage><pages>1086-1089</pages><issn>0305-7453</issn><issn>1460-2091</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs ≥ 4 mg/L. Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15102749</pmid><doi>10.1093/jac/dkh228</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Acremonium allylamines Amphotericin B - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - pharmacology antifungals Aspergillus spp Biological and medical sciences Fungi - drug effects Fusarium Itraconazole - pharmacology Medical sciences Microbial Sensitivity Tests Mucorales Naphthalenes - pharmacology Paecilomyces Penicillium Pharmacology. Drug treatments Pyrimidines - pharmacology Scedosporium Scopulariopsis brevicaulis Spain Spanish filamentous fungi Triazoles - pharmacology Trichoderma Voriconazole |
| title | In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi |
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