PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity

PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity

Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic & biomolecular chemistry 2004-06, Vol.2 (11), p.1603-1611
Hauptverfasser: Cernovská, Katerina, Kemter, Miriam, Gallmeier, Hans-Christoph, Rzepecki, Petra, Schrader, Thomas, König, Burkhard
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1611
container_issue 11
container_start_page 1603
container_title Organic & biomolecular chemistry
container_volume 2
creator Cernovská, Katerina
Kemter, Miriam
Gallmeier, Hans-Christoph
Rzepecki, Petra
Schrader, Thomas
König, Burkhard
description Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.
doi_str_mv 10.1039/b401968g
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71958511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71958511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c279t-6095546f21dcd966fdaed184f49a8b4a78b162f7f75592c99f1f79ba12e340d43</originalsourceid><addsrcrecordid>eNpFkFFLwzAUhYMobk7BXyB5El-qSZo0zaOOOYWBe9DnkjY3W6RdapMy6q-3sqFP91z4OBw-hK4puackVQ8lJ1Rl-eYETSmXMiEiVad_mZEJugjhk4yQzPg5mlBBM8Yom6L1erFMQt-2votgcBh2cQvBBewtbodOf_sasK_dxuvGGQh47-IWt9DG8cMlRJ2ELUDE2lq3c3G4RGdW1wGujneGPp4X7_OXZPW2fJ0_rpKKSRWTjCgheGYZNZVRWWaNBkNzbrnSecm1zMtxopVWCqFYpZSlVqpSUwYpJ4anM3R76G07_9VDiEXjQgV1rXfg-1BIqkQuKB3BuwNYdT6EDmzRdq7R3VBQUvzaK54O9pYjenPs7MsGzD941JX-AM8vakY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71958511</pqid></control><display><type>article</type><title>PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity</title><source>Royal Society of Chemistry Journals Archive (1841-2007)</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Cernovská, Katerina ; Kemter, Miriam ; Gallmeier, Hans-Christoph ; Rzepecki, Petra ; Schrader, Thomas ; König, Burkhard</creator><creatorcontrib>Cernovská, Katerina ; Kemter, Miriam ; Gallmeier, Hans-Christoph ; Rzepecki, Petra ; Schrader, Thomas ; König, Burkhard</creatorcontrib><description>Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/b401968g</identifier><identifier>PMID: 15162212</identifier><language>eng</language><publisher>England</publisher><ispartof>Organic &amp; biomolecular chemistry, 2004-06, Vol.2 (11), p.1603-1611</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c279t-6095546f21dcd966fdaed184f49a8b4a78b162f7f75592c99f1f79ba12e340d43</citedby><cites>FETCH-LOGICAL-c279t-6095546f21dcd966fdaed184f49a8b4a78b162f7f75592c99f1f79ba12e340d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2818,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15162212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cernovská, Katerina</creatorcontrib><creatorcontrib>Kemter, Miriam</creatorcontrib><creatorcontrib>Gallmeier, Hans-Christoph</creatorcontrib><creatorcontrib>Rzepecki, Petra</creatorcontrib><creatorcontrib>Schrader, Thomas</creatorcontrib><creatorcontrib>König, Burkhard</creatorcontrib><title>PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity</title><title>Organic &amp; biomolecular chemistry</title><addtitle>Org Biomol Chem</addtitle><description>Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.</description><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpFkFFLwzAUhYMobk7BXyB5El-qSZo0zaOOOYWBe9DnkjY3W6RdapMy6q-3sqFP91z4OBw-hK4puackVQ8lJ1Rl-eYETSmXMiEiVad_mZEJugjhk4yQzPg5mlBBM8Yom6L1erFMQt-2votgcBh2cQvBBewtbodOf_sasK_dxuvGGQh47-IWt9DG8cMlRJ2ELUDE2lq3c3G4RGdW1wGujneGPp4X7_OXZPW2fJ0_rpKKSRWTjCgheGYZNZVRWWaNBkNzbrnSecm1zMtxopVWCqFYpZSlVqpSUwYpJ4anM3R76G07_9VDiEXjQgV1rXfg-1BIqkQuKB3BuwNYdT6EDmzRdq7R3VBQUvzaK54O9pYjenPs7MsGzD941JX-AM8vakY</recordid><startdate>20040607</startdate><enddate>20040607</enddate><creator>Cernovská, Katerina</creator><creator>Kemter, Miriam</creator><creator>Gallmeier, Hans-Christoph</creator><creator>Rzepecki, Petra</creator><creator>Schrader, Thomas</creator><creator>König, Burkhard</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040607</creationdate><title>PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity</title><author>Cernovská, Katerina ; Kemter, Miriam ; Gallmeier, Hans-Christoph ; Rzepecki, Petra ; Schrader, Thomas ; König, Burkhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-6095546f21dcd966fdaed184f49a8b4a78b162f7f75592c99f1f79ba12e340d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cernovská, Katerina</creatorcontrib><creatorcontrib>Kemter, Miriam</creatorcontrib><creatorcontrib>Gallmeier, Hans-Christoph</creatorcontrib><creatorcontrib>Rzepecki, Petra</creatorcontrib><creatorcontrib>Schrader, Thomas</creatorcontrib><creatorcontrib>König, Burkhard</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic &amp; biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cernovská, Katerina</au><au>Kemter, Miriam</au><au>Gallmeier, Hans-Christoph</au><au>Rzepecki, Petra</au><au>Schrader, Thomas</au><au>König, Burkhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity</atitle><jtitle>Organic &amp; biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2004-06-07</date><risdate>2004</risdate><volume>2</volume><issue>11</issue><spage>1603</spage><epage>1611</epage><pages>1603-1611</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.</abstract><cop>England</cop><pmid>15162212</pmid><doi>10.1039/b401968g</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1477-0520
ispartof Organic & biomolecular chemistry, 2004-06, Vol.2 (11), p.1603-1611
issn 1477-0520
1477-0539
language eng
recordid cdi_proquest_miscellaneous_71958511
source Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T19%3A40%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PEG-supported%20synthesis%20of%20pyrazole%20oligoamides%20with%20peptide%20beta-sheet%20affinity&rft.jtitle=Organic%20&%20biomolecular%20chemistry&rft.au=Cernovsk%C3%A1,%20Katerina&rft.date=2004-06-07&rft.volume=2&rft.issue=11&rft.spage=1603&rft.epage=1611&rft.pages=1603-1611&rft.issn=1477-0520&rft.eissn=1477-0539&rft_id=info:doi/10.1039/b401968g&rft_dat=%3Cproquest_cross%3E71958511%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71958511&rft_id=info:pmid/15162212&rfr_iscdi=true