Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells

Statins inhibit 3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase, which catalyzes conversion of HMG‐CoA to mevalonate, a rate‐limiting step in cholesterol synthesis. The present study was undertaken to understand the events of osteoblast differentiation induced by statins. Simvastatin at 10...

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Veröffentlicht in:	Journal of cellular biochemistry 2004-06, Vol.92 (3), p.458-471
Hauptverfasser:	Maeda, Toyonobu, Matsunuma, Ayako, Kurahashi, Izuru, Yanagawa, Toru, Yoshida, Hiroshi, Horiuchi, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - genetics bone sialoprotein Calcification, Physiologic - drug effects Cell Differentiation - drug effects Cell Line Collagen - genetics Gene Expression Regulation - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Integrin-Binding Sialoprotein Mice mineralization Neoplasm Proteins - genetics osteoblast differentiation Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sialoglycoproteins - genetics statins Transcription Factors - genetics Transforming Growth Factor beta - genetics vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics
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