Reversal of acquired cisplatin resistance by modulation of metallothionein in transplanted murine tumors

Background: The platinum‐based chemotherapeutic agent cisplatin is involved in a broad spectrum of activities against human systemic malignancies. However, acquired resistance to cisplatin reduces its clinical efficacy. Elucidation of the molecular basis of cisplatin resistance is required to improv...

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Veröffentlicht in:	International journal of urology 2004-06, Vol.11 (6), p.407-415
Hauptverfasser:	SAGA, YUJI, HASHIMOTO, HIROSHI, YACHIKU, SUNAO, IWATA, TATSUYA, TOKUMITSU, MASAYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	acquired resistance Alkynes - pharmacology Animals Antineoplastic Agents - pharmacology biochemical modulation Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - metabolism cisplatin Cisplatin - pharmacology Cystathionine gamma-Lyase - antagonists & inhibitors Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Enzyme Inhibitors - pharmacology Female Glutathione - metabolism Glycine - analogs & derivatives Glycine - pharmacology Injections, Intraperitoneal metallothionein Metallothionein - biosynthesis Metallothionein - drug effects Mice Mice, Inbred C3H Neoplasm Transplantation propargylglycine Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism
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