Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat
We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw withdrawal frequency (PWF) in response to noxious mechanical stimuli, in male Sprague–Dawley rats after spinal hemisection at T13 in young (40 days),...
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| Veröffentlicht in: | Neuroscience letters 2004-05, Vol.362 (3), p.232-235 |
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| creator | Gwak, Young Seob Hains, Bryan C. Johnson, Kathia M. Hulsebosch, Claire E. |
| description | We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw withdrawal frequency (PWF) in response to noxious mechanical stimuli, in male Sprague–Dawley rats after spinal hemisection at T13 in young (40 days), adult (60 days) and middle-age (1 year) groups. Behavioral outcomes were measured weekly for 4 weeks in both SCI and sham groups. Following SCI, the young and adult groups recovered significantly more locomotor function, at a more rapid rate, than did the middle-age group. The PWF of the young group was significantly increased, the adult group was significantly decreased, and the middle-age group showed no significant change in fore- and hindlimbs when compared to other age groups, pre-injury and sham controls. These results support age-dependent behavioral outcomes after SCI. |
| doi_str_mv | 10.1016/j.neulet.2004.03.019 |
| format | Article |
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Behavioral outcomes were measured weekly for 4 weeks in both SCI and sham groups. Following SCI, the young and adult groups recovered significantly more locomotor function, at a more rapid rate, than did the middle-age group. The PWF of the young group was significantly increased, the adult group was significantly decreased, and the middle-age group showed no significant change in fore- and hindlimbs when compared to other age groups, pre-injury and sham controls. These results support age-dependent behavioral outcomes after SCI.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.03.019</identifier><identifier>PMID: 15158021</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age ; Age Factors ; Animals ; Behavior, Animal ; Biological and medical sciences ; Forelimb - physiopathology ; Fundamental and applied biological sciences. Psychology ; Hemisection ; Hindlimb - physiopathology ; Hyperalgesia - etiology ; Locomotor ; Male ; Motor Activity - physiology ; Pain Measurement ; Paw withdrawal frequency ; Rats ; Rats, Sprague-Dawley ; Recovery of Function - physiology ; Spinal Cord Injuries - physiopathology ; Spinal cord injury ; Time Factors ; Touch ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-05, Vol.362 (3), p.232-235</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-8e6bacbfb09054660b1a6cdbf8919b779cedacdd95390c755b8f1065b49a1e483</citedby><cites>FETCH-LOGICAL-c485t-8e6bacbfb09054660b1a6cdbf8919b779cedacdd95390c755b8f1065b49a1e483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2004.03.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15730775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15158021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gwak, Young Seob</creatorcontrib><creatorcontrib>Hains, Bryan C.</creatorcontrib><creatorcontrib>Johnson, Kathia M.</creatorcontrib><creatorcontrib>Hulsebosch, Claire E.</creatorcontrib><title>Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw withdrawal frequency (PWF) in response to noxious mechanical stimuli, in male Sprague–Dawley rats after spinal hemisection at T13 in young (40 days), adult (60 days) and middle-age (1 year) groups. Behavioral outcomes were measured weekly for 4 weeks in both SCI and sham groups. Following SCI, the young and adult groups recovered significantly more locomotor function, at a more rapid rate, than did the middle-age group. The PWF of the young group was significantly increased, the adult group was significantly decreased, and the middle-age group showed no significant change in fore- and hindlimbs when compared to other age groups, pre-injury and sham controls. These results support age-dependent behavioral outcomes after SCI.</description><subject>Age</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Forelimb - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemisection</subject><subject>Hindlimb - physiopathology</subject><subject>Hyperalgesia - etiology</subject><subject>Locomotor</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Pain Measurement</subject><subject>Paw withdrawal frequency</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function - physiology</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal cord injury</subject><subject>Time Factors</subject><subject>Touch</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2r1DAUhoMo3vHqPxDJRnetJ23TJBtBLn7BgBtdhzQ5nZuhTWrSXpl_b4YZ0ZWuzuI87-HwPoS8ZFAzYP3bYx1wm3CtG4CuhrYGph6RHZOiqYQSzWOygxa6qlUd3JBnOR8BgDPePSU3rEwJDduRtI82znGNiSa08QHTiZrg6Iz23gRvzUTvTwsmMx0we0PHOE3xpw8HmhcfytbG5KgPx60EHS5YsjFQc0BqVrr6GWkcf-99oMmsz8mT0UwZX1znLfn-8cO3u8_V_uunL3fv95XtJF8rif1g7DAOoIB3fQ8DM711wygVU4MQyqIz1jnFWwVWcD7IkUHPh04Zhp1sb8mby90lxR8b5lXPPlucJhMwblkLprgQkv8XZEI2DWesgN0FtCnmnHDUS_KzSSfNQJ-l6KO-SNFnKRpaXaSU2Kvr_W2Y0f0JXS0U4PUVMLk0PiYTrM9_caIFIc6PvrtwWGp78Jh0th5DKcIXeat20f_7k19lPq5t</recordid><startdate>20040527</startdate><enddate>20040527</enddate><creator>Gwak, Young Seob</creator><creator>Hains, Bryan C.</creator><creator>Johnson, Kathia M.</creator><creator>Hulsebosch, Claire E.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040527</creationdate><title>Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat</title><author>Gwak, Young Seob ; Hains, Bryan C. ; Johnson, Kathia M. ; Hulsebosch, Claire E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-8e6bacbfb09054660b1a6cdbf8919b779cedacdd95390c755b8f1065b49a1e483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Forelimb - physiopathology</topic><topic>Fundamental and applied biological sciences. 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Behavioral outcomes were measured weekly for 4 weeks in both SCI and sham groups. Following SCI, the young and adult groups recovered significantly more locomotor function, at a more rapid rate, than did the middle-age group. The PWF of the young group was significantly increased, the adult group was significantly decreased, and the middle-age group showed no significant change in fore- and hindlimbs when compared to other age groups, pre-injury and sham controls. These results support age-dependent behavioral outcomes after SCI.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15158021</pmid><doi>10.1016/j.neulet.2004.03.019</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2004-05, Vol.362 (3), p.232-235 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Age Factors Animals Behavior, Animal Biological and medical sciences Forelimb - physiopathology Fundamental and applied biological sciences. Psychology Hemisection Hindlimb - physiopathology Hyperalgesia - etiology Locomotor Male Motor Activity - physiology Pain Measurement Paw withdrawal frequency Rats Rats, Sprague-Dawley Recovery of Function - physiology Spinal Cord Injuries - physiopathology Spinal cord injury Time Factors Touch Vertebrates: nervous system and sense organs |
| title | Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat |
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