Lower Prevalence of Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease But Not With Chronic Obstructive Pulmonary Disease - Antibiotic Use in the History Does Not Play a Significant Role
ABSTRACT Background. Patients with inflammatory bowel disease have lower prevalence of Helicobacter pylori infection, but the exact reason for this is not yet clear. Aim. To examine whether the antibiotics frequently used in inflammatory bowel disease are responsible for the lower prevalence of H....
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| Veröffentlicht in: | Helicobacter (Cambridge, Mass.) Mass.), 2004-06, Vol.9 (3), p.278-283 |
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| container_title | Helicobacter (Cambridge, Mass.) |
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| creator | Prónai, László Schandl, László Orosz, Zsuzsa Magyar, Pál Tulassay, Zsolt |
| description | ABSTRACT
Background. Patients with inflammatory bowel disease have lower prevalence of Helicobacter pylori infection, but the exact reason for this is not yet clear.
Aim. To examine whether the antibiotics frequently used in inflammatory bowel disease are responsible for the lower prevalence of H. pylori infection. Patients with chronic obstructive pulmonary disease on prolonged previous antibiotic therapy were used for comparison.
Methods. Presence/absence of H. pylori infection was detected by a 13C‐urea breath test in 133 patients with inflammatory bowel disease (82 ulcerative colitis, and 51 Crohn's disease) and compared with that of 135 patients with chronic obstructive pulmonary disease and with two age‐matched control groups (200 patients each). Primary disease location, duration of disease and detailed analysis of previous and current medication (dose and duration of antibiotics, steroids, 5‐aminosalicylic acid) were analysed in each cases.
Results. Seventeen of the 133 patients with inflammatory bowel disease [12.2% (10/82) of ulcerative colitis and 13.7% (7/51) of Crohn's disease] and 90/135 patients with chronic obstructive pulmonary disease (66.7%) were positive for H. pylori. A total of 78/200 (39%) for the inflammatory‐bowel‐disease‐group‐matched controls and 110/210 (55%) for the chronic‐obstructive‐pulmonary‐disease‐matched controls were positive for H. pylori. The history of any antibiotic or steroid therapy had no influence on H. pylori status of patients with inflammatory bowel disease.
Conclusion. The prevalence of H. pylori compared to the age‐matched controls is significantly lower in patients with inflammatory bowel disease but not in those with chronic obstructive pulmonary disease. Antibiotic use is not responsible for the lower prevalence of H. pylori infection in patients with inflammatory bowel disease. |
| doi_str_mv | 10.1111/j.1083-4389.2004.00223.x |
| format | Article |
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Background. Patients with inflammatory bowel disease have lower prevalence of Helicobacter pylori infection, but the exact reason for this is not yet clear.
Aim. To examine whether the antibiotics frequently used in inflammatory bowel disease are responsible for the lower prevalence of H. pylori infection. Patients with chronic obstructive pulmonary disease on prolonged previous antibiotic therapy were used for comparison.
Methods. Presence/absence of H. pylori infection was detected by a 13C‐urea breath test in 133 patients with inflammatory bowel disease (82 ulcerative colitis, and 51 Crohn's disease) and compared with that of 135 patients with chronic obstructive pulmonary disease and with two age‐matched control groups (200 patients each). Primary disease location, duration of disease and detailed analysis of previous and current medication (dose and duration of antibiotics, steroids, 5‐aminosalicylic acid) were analysed in each cases.
Results. Seventeen of the 133 patients with inflammatory bowel disease [12.2% (10/82) of ulcerative colitis and 13.7% (7/51) of Crohn's disease] and 90/135 patients with chronic obstructive pulmonary disease (66.7%) were positive for H. pylori. A total of 78/200 (39%) for the inflammatory‐bowel‐disease‐group‐matched controls and 110/210 (55%) for the chronic‐obstructive‐pulmonary‐disease‐matched controls were positive for H. pylori. The history of any antibiotic or steroid therapy had no influence on H. pylori status of patients with inflammatory bowel disease.
Conclusion. The prevalence of H. pylori compared to the age‐matched controls is significantly lower in patients with inflammatory bowel disease but not in those with chronic obstructive pulmonary disease. Antibiotic use is not responsible for the lower prevalence of H. pylori infection in patients with inflammatory bowel disease.</description><identifier>ISSN: 1083-4389</identifier><identifier>EISSN: 1523-5378</identifier><identifier>DOI: 10.1111/j.1083-4389.2004.00223.x</identifier><identifier>PMID: 15165265</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; chronic obstructive pulmonary disease ; Crohn's disease ; Female ; Helicobacter Infections - complications ; Helicobacter Infections - epidemiology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; Humans ; inflammatory bowel disease ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory Bowel Diseases - epidemiology ; Inflammatory Bowel Diseases - microbiology ; Male ; Middle Aged ; Prevalence ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - microbiology ; ulcerative colitis</subject><ispartof>Helicobacter (Cambridge, Mass.), 2004-06, Vol.9 (3), p.278-283</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4333-1efe7bac54ff4bed35090440c8a76a0f7b5ab6bed81ac2f9a2f539205783818c3</citedby><cites>FETCH-LOGICAL-c4333-1efe7bac54ff4bed35090440c8a76a0f7b5ab6bed81ac2f9a2f539205783818c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1083-4389.2004.00223.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1083-4389.2004.00223.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15165265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prónai, László</creatorcontrib><creatorcontrib>Schandl, László</creatorcontrib><creatorcontrib>Orosz, Zsuzsa</creatorcontrib><creatorcontrib>Magyar, Pál</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><title>Lower Prevalence of Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease But Not With Chronic Obstructive Pulmonary Disease - Antibiotic Use in the History Does Not Play a Significant Role</title><title>Helicobacter (Cambridge, Mass.)</title><addtitle>Helicobacter</addtitle><description>ABSTRACT
Background. Patients with inflammatory bowel disease have lower prevalence of Helicobacter pylori infection, but the exact reason for this is not yet clear.
Aim. To examine whether the antibiotics frequently used in inflammatory bowel disease are responsible for the lower prevalence of H. pylori infection. Patients with chronic obstructive pulmonary disease on prolonged previous antibiotic therapy were used for comparison.
Methods. Presence/absence of H. pylori infection was detected by a 13C‐urea breath test in 133 patients with inflammatory bowel disease (82 ulcerative colitis, and 51 Crohn's disease) and compared with that of 135 patients with chronic obstructive pulmonary disease and with two age‐matched control groups (200 patients each). Primary disease location, duration of disease and detailed analysis of previous and current medication (dose and duration of antibiotics, steroids, 5‐aminosalicylic acid) were analysed in each cases.
Results. Seventeen of the 133 patients with inflammatory bowel disease [12.2% (10/82) of ulcerative colitis and 13.7% (7/51) of Crohn's disease] and 90/135 patients with chronic obstructive pulmonary disease (66.7%) were positive for H. pylori. A total of 78/200 (39%) for the inflammatory‐bowel‐disease‐group‐matched controls and 110/210 (55%) for the chronic‐obstructive‐pulmonary‐disease‐matched controls were positive for H. pylori. The history of any antibiotic or steroid therapy had no influence on H. pylori status of patients with inflammatory bowel disease.
Conclusion. The prevalence of H. pylori compared to the age‐matched controls is significantly lower in patients with inflammatory bowel disease but not in those with chronic obstructive pulmonary disease. Antibiotic use is not responsible for the lower prevalence of H. pylori infection in patients with inflammatory bowel disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>chronic obstructive pulmonary disease</subject><subject>Crohn's disease</subject><subject>Female</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Pulmonary Disease, Chronic Obstructive - drug therapy</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Pulmonary Disease, Chronic Obstructive - microbiology</subject><subject>ulcerative colitis</subject><issn>1083-4389</issn><issn>1523-5378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uEzEUhUcIREvhFZBX7CbY4_GMR2LTpKWpFLURbenS8rjXxMEzTm1Pmzwmb4TzU1iCN7669zvnyj5ZhggekXQ-L0cEc5qXlDejAuNyhHFR0NH6VXZMWEFzRmv-OtUv0FH2LoQlxpjRsnmbHRFGKlZU7Dj7NXPP4NHcw5O00CtATqMpWKNcK1VMo9XGOm_QZa9BReN6ZHo0l9FAHwO6N3GxHVnZdTI6v0Hj5GfRmQkgA6DxENGVi3tusvCuNwpdtyH6IZk9AZoPtnO9TMIXSY5O-2ha42JC71Ij7YsLQFMTdgvOHISd59zKDZLoxvzojTZK9hF9cxbeZ2-0tAE-HO6T7O7r-e1kms-uLy4np7NclZTSnICGOj2RlVqXLTxQhhtcllhxWVcS67plsq3SgBOpCt3IQjPaFJjVnHLCFT3JPu19V949DhCi6ExQYK3swQ1B1KRhdYXxP0FSNw1tOE8g34PKuxA8aLHypkt_IwgW29zFUmwjFdtIxTZ3sctdrJP042HH0Hbw8Fd4CDoBX_bAs7Gw-W9jMT2fpSLJ8708hQDrP3Lpf4qqpjUT91cXYs5ux_jmO082vwHDVc5j</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Prónai, László</creator><creator>Schandl, László</creator><creator>Orosz, Zsuzsa</creator><creator>Magyar, Pál</creator><creator>Tulassay, Zsolt</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200406</creationdate><title>Lower Prevalence of Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease But Not With Chronic Obstructive Pulmonary Disease - Antibiotic Use in the History Does Not Play a Significant Role</title><author>Prónai, László ; Schandl, László ; Orosz, Zsuzsa ; Magyar, Pál ; Tulassay, Zsolt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4333-1efe7bac54ff4bed35090440c8a76a0f7b5ab6bed81ac2f9a2f539205783818c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>chronic obstructive pulmonary disease</topic><topic>Crohn's disease</topic><topic>Female</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - drug therapy</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Inflammatory Bowel Diseases - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Pulmonary Disease, Chronic Obstructive - microbiology</topic><topic>ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prónai, László</creatorcontrib><creatorcontrib>Schandl, László</creatorcontrib><creatorcontrib>Orosz, Zsuzsa</creatorcontrib><creatorcontrib>Magyar, Pál</creatorcontrib><creatorcontrib>Tulassay, Zsolt</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Helicobacter (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prónai, László</au><au>Schandl, László</au><au>Orosz, Zsuzsa</au><au>Magyar, Pál</au><au>Tulassay, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower Prevalence of Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease But Not With Chronic Obstructive Pulmonary Disease - Antibiotic Use in the History Does Not Play a Significant Role</atitle><jtitle>Helicobacter (Cambridge, Mass.)</jtitle><addtitle>Helicobacter</addtitle><date>2004-06</date><risdate>2004</risdate><volume>9</volume><issue>3</issue><spage>278</spage><epage>283</epage><pages>278-283</pages><issn>1083-4389</issn><eissn>1523-5378</eissn><abstract>ABSTRACT
Background. Patients with inflammatory bowel disease have lower prevalence of Helicobacter pylori infection, but the exact reason for this is not yet clear.
Aim. To examine whether the antibiotics frequently used in inflammatory bowel disease are responsible for the lower prevalence of H. pylori infection. Patients with chronic obstructive pulmonary disease on prolonged previous antibiotic therapy were used for comparison.
Methods. Presence/absence of H. pylori infection was detected by a 13C‐urea breath test in 133 patients with inflammatory bowel disease (82 ulcerative colitis, and 51 Crohn's disease) and compared with that of 135 patients with chronic obstructive pulmonary disease and with two age‐matched control groups (200 patients each). Primary disease location, duration of disease and detailed analysis of previous and current medication (dose and duration of antibiotics, steroids, 5‐aminosalicylic acid) were analysed in each cases.
Results. Seventeen of the 133 patients with inflammatory bowel disease [12.2% (10/82) of ulcerative colitis and 13.7% (7/51) of Crohn's disease] and 90/135 patients with chronic obstructive pulmonary disease (66.7%) were positive for H. pylori. A total of 78/200 (39%) for the inflammatory‐bowel‐disease‐group‐matched controls and 110/210 (55%) for the chronic‐obstructive‐pulmonary‐disease‐matched controls were positive for H. pylori. The history of any antibiotic or steroid therapy had no influence on H. pylori status of patients with inflammatory bowel disease.
Conclusion. The prevalence of H. pylori compared to the age‐matched controls is significantly lower in patients with inflammatory bowel disease but not in those with chronic obstructive pulmonary disease. Antibiotic use is not responsible for the lower prevalence of H. pylori infection in patients with inflammatory bowel disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15165265</pmid><doi>10.1111/j.1083-4389.2004.00223.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Anti-Bacterial Agents - therapeutic use chronic obstructive pulmonary disease Crohn's disease Female Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - isolation & purification Humans inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - microbiology Male Middle Aged Prevalence Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - microbiology ulcerative colitis |
| title | Lower Prevalence of Helicobacter pylori Infection in Patients With Inflammatory Bowel Disease But Not With Chronic Obstructive Pulmonary Disease - Antibiotic Use in the History Does Not Play a Significant Role |
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