Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation

We tested the pharmacological action of sulfur-containing amino acids on the development of liver fibrosis in rats and on the function of cultured stellate cells. Liver fibrosis was induced in rats by thioacetamide administration or by ligating the common bile duct. DNA synthesis of cultured stellat...

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Veröffentlicht in:	Journal of hepatology 2004-06, Vol.40 (6), p.917-925
Hauptverfasser:	Matsui, Hiroko, Ikeda, Kazuo, Nakajima, Yuji, Horikawa, Saburo, Imanishi, Yukihiro, Kawada, Norifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Sulfur - pharmacology Animals Base Sequence Biological and medical sciences Collagen Collagen - genetics Cysteine - pharmacology Disease Models, Animal DNA Primers Fibroblasts - cytology Fibroblasts - physiology Gastroenterology. Liver. Pancreas. Abdomen l-Cysteine l-Methionine Liver - cytology Liver - drug effects Liver - physiology Liver Cirrhosis, Experimental - pathology Liver Cirrhosis, Experimental - physiopathology Liver Cirrhosis, Experimental - prevention & control Liver fibrosis Male Medical sciences Methionine - pharmacology Methionine adenosyltransferase Platelet-derived growth factor-BB Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Stellate cells Thioacetamide - pharmacology
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