cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection

The first component of complement, C1, is a multi-molecular complex comprising of C1q and the Ca 2+-dependent tetramer C1r 2–C1s 2. The traditional role of C1q within the complex is that of recognition signal—a signal, which is instantly converted into a highly specific intramolecular proteolytic ac...

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