Application of the trak-C™ HCV core assay for monitoring antiviral activity in HCV replication systems

The Ortho ® trak-C™ immunoassay has recently established detection of the HCV core antigen as a viable indirect marker of HCV replication in clinical samples. In this study, trak-C™ is used to monitor HCV replication in three pre-clinical models: the cellular HCV replicon system, transient transfect...

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Veröffentlicht in:	Journal of virological methods 2004-06, Vol.118 (1), p.23-31
Hauptverfasser:	Cagnon, Laurence, Wagaman, Pamela, Bartenschlager, Ralf, Pietschmann, Thomas, Gao, Tiejun, Kneteman, Norman M, Tyrrell, David L.J, Bahl, Chander, Niven, Patrick, Lee, Stephen, Simmen, Kenneth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Antiviral assay Biological and medical sciences Clone Cells Enzyme-Linked Immunosorbent Assay - methods Enzyme-Linked Immunosorbent Assay - statistics & numerical data Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genome, Viral HCV core HCV replicon Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - physiology Hepatitis C - drug therapy Hepatitis C - virology Humans Interferon Interferon Type I - pharmacology Mice Mice, SCID Mice, Transgenic Microbiology Recombinant Proteins Sensitivity and Specificity Techniques used in virology Viral Core Proteins - analysis Viral Core Proteins - genetics Viremia - drug therapy Viremia - virology Virology Virology - methods Virology - statistics & numerical data Virus Replication - drug effects
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