Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies
BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs. STUDY DESIGN AND METHODS : A total of 413...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2002-06, Vol.42 (6), p.766-773 |
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| creator | Shimada, Eiko Tadokoro, Kenji Watanabe, Yoshihisa Ikeda, Kazuyo Niihara, Hiromi Maeda, Ikiko Isa, Kazumi Moriya, Susumu Ashida, Takashi Mitsunaga, Shigeki Nakajima, Kazunori Juji, Takeo |
| description | BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs.
STUDY DESIGN AND METHODS : A total of 4138 cases of voluntarily reported NHTRs in Japan, including 367 cases of immediate‐onset anaphylactic NHTRs, were examined to identify haptoglobin deficiency. Serum haptoglobin IgG and IgE antibodies were determined in haptoglobin‐deficient patients to elucidate the mechanism underlying the transfusion reactions.
RESULTS
: Seven patients with haptoglobin deficiency were identified. Six of them experienced severe and acute NHTRs. Six of them were identified to be homozygous for the
Hp
del
allele of the haptoglobin gene. Both haptoglobin IgG and IgE antibodies were detected in serum samples of all the patients. The stimulative effects of blood transfusion on the production of hap‐ toglobin antibodies in the patients and the relation‐ ship between the presence of the antibodies and the occurrence of the transfusion reactions were observed.
CONCLUSION : Anaphylactic NHTRs in these patients with haptoglobin deficiency associated with serum haptoglobin antibodies were suggested to be prevalent in Japan. In addition to IgG antibodies, IgE haptoglobin antibodies detected in the sera of such patients were suggested to play a role in the occurrence of the reactions. |
| doi_str_mv | 10.1046/j.1537-2995.2002.00117.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71956449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71956449</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4347-d4fe2c1f02abec1ac49f0ac2889f19eb8ba3fbe0ec8a628ec6ab181eda5c63953</originalsourceid><addsrcrecordid>eNqNkV1v0zAUhi0EYmXjL6DcwF2CT-x8SdxM01oGE2zTJhA31olzvLqkSRa7WvvvcWi1ccnVax0_r209ZiwCngCX-cdVApko4rSqsiTlPE04ByiS7Qs2e9p4yWacS4gBRHrE3ji34oGsOLxmR5CCLLiAGWtPOxyWuxa1tzryI3bObJztu2ikadZ3LrJdtMTB9_dtX9subshYbanz0YB-Shc9Wr-MLu7PI-yakIt_-TDztu4bS-6EvTLYOnp7yGN2Nz-_PfscX35fXJydXsZaClnEjTSUajA8xZo0oJaV4ajTsqwMVFSXNQpTEyddYp6WpHOsoQRqMNO5qDJxzD7szx3G_mFDzqu1dZraFjvqN04VUGW5lFUAyz2ox965kYwaRrvGcaeAq8m0WqlJqJqEqsm0-mtabUP13eGOTb2m5rl4UBuA9wcAncbWBLXaumdOlOF7ch64T3vu0ba0--8HqNubeViEeryvW-dp-1TH8bfKC1Fk6se3hZovfn69-nV9rb6IP6dCq8k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71956449</pqid></control><display><type>article</type><title>Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Shimada, Eiko ; Tadokoro, Kenji ; Watanabe, Yoshihisa ; Ikeda, Kazuyo ; Niihara, Hiromi ; Maeda, Ikiko ; Isa, Kazumi ; Moriya, Susumu ; Ashida, Takashi ; Mitsunaga, Shigeki ; Nakajima, Kazunori ; Juji, Takeo</creator><creatorcontrib>Shimada, Eiko ; Tadokoro, Kenji ; Watanabe, Yoshihisa ; Ikeda, Kazuyo ; Niihara, Hiromi ; Maeda, Ikiko ; Isa, Kazumi ; Moriya, Susumu ; Ashida, Takashi ; Mitsunaga, Shigeki ; Nakajima, Kazunori ; Juji, Takeo</creatorcontrib><description>BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs.
STUDY DESIGN AND METHODS : A total of 4138 cases of voluntarily reported NHTRs in Japan, including 367 cases of immediate‐onset anaphylactic NHTRs, were examined to identify haptoglobin deficiency. Serum haptoglobin IgG and IgE antibodies were determined in haptoglobin‐deficient patients to elucidate the mechanism underlying the transfusion reactions.
RESULTS
: Seven patients with haptoglobin deficiency were identified. Six of them experienced severe and acute NHTRs. Six of them were identified to be homozygous for the
Hp
del
allele of the haptoglobin gene. Both haptoglobin IgG and IgE antibodies were detected in serum samples of all the patients. The stimulative effects of blood transfusion on the production of hap‐ toglobin antibodies in the patients and the relation‐ ship between the presence of the antibodies and the occurrence of the transfusion reactions were observed.
CONCLUSION : Anaphylactic NHTRs in these patients with haptoglobin deficiency associated with serum haptoglobin antibodies were suggested to be prevalent in Japan. In addition to IgG antibodies, IgE haptoglobin antibodies detected in the sera of such patients were suggested to play a role in the occurrence of the reactions.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1046/j.1537-2995.2002.00117.x</identifier><identifier>PMID: 12147031</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Boston, MA, USA: Blackwell Science Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Anaphylaxis - epidemiology ; Anaphylaxis - etiology ; Anaphylaxis - immunology ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibody Specificity ; Arteriosclerosis Obliterans - immunology ; Arteriosclerosis Obliterans - therapy ; Basophils - immunology ; Basophils - metabolism ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Blotting, Western ; Child ; Child, Preschool ; Comorbidity ; Enzyme-Linked Immunosorbent Assay ; Female ; Gene Deletion ; Genotype ; Haptoglobins - deficiency ; Haptoglobins - genetics ; Humans ; Hypersensitivity, Immediate - etiology ; Hypersensitivity, Immediate - immunology ; Immunization ; Immunodiffusion ; Immunoglobulin E - immunology ; Immunoglobulin G - immunology ; Infant ; Infant, Newborn ; Isoantibodies - immunology ; Japan - epidemiology ; Kidney Failure, Chronic - immunology ; Kidney Failure, Chronic - therapy ; Male ; Mass Screening ; Mast Cells - immunology ; Mast Cells - metabolism ; Medical sciences ; Middle Aged ; Myelodysplastic Syndromes - immunology ; Myelodysplastic Syndromes - therapy ; Pregnancy ; Pregnancy Complications - immunology ; Prevalence ; Receptors, IgE - immunology ; Registries ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Urinary Bladder Neoplasms - immunology ; Urinary Bladder Neoplasms - therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2002-06, Vol.42 (6), p.766-773</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4347-d4fe2c1f02abec1ac49f0ac2889f19eb8ba3fbe0ec8a628ec6ab181eda5c63953</citedby><cites>FETCH-LOGICAL-c4347-d4fe2c1f02abec1ac49f0ac2889f19eb8ba3fbe0ec8a628ec6ab181eda5c63953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1537-2995.2002.00117.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1537-2995.2002.00117.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13800460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12147031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimada, Eiko</creatorcontrib><creatorcontrib>Tadokoro, Kenji</creatorcontrib><creatorcontrib>Watanabe, Yoshihisa</creatorcontrib><creatorcontrib>Ikeda, Kazuyo</creatorcontrib><creatorcontrib>Niihara, Hiromi</creatorcontrib><creatorcontrib>Maeda, Ikiko</creatorcontrib><creatorcontrib>Isa, Kazumi</creatorcontrib><creatorcontrib>Moriya, Susumu</creatorcontrib><creatorcontrib>Ashida, Takashi</creatorcontrib><creatorcontrib>Mitsunaga, Shigeki</creatorcontrib><creatorcontrib>Nakajima, Kazunori</creatorcontrib><creatorcontrib>Juji, Takeo</creatorcontrib><title>Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs.
STUDY DESIGN AND METHODS : A total of 4138 cases of voluntarily reported NHTRs in Japan, including 367 cases of immediate‐onset anaphylactic NHTRs, were examined to identify haptoglobin deficiency. Serum haptoglobin IgG and IgE antibodies were determined in haptoglobin‐deficient patients to elucidate the mechanism underlying the transfusion reactions.
RESULTS
: Seven patients with haptoglobin deficiency were identified. Six of them experienced severe and acute NHTRs. Six of them were identified to be homozygous for the
Hp
del
allele of the haptoglobin gene. Both haptoglobin IgG and IgE antibodies were detected in serum samples of all the patients. The stimulative effects of blood transfusion on the production of hap‐ toglobin antibodies in the patients and the relation‐ ship between the presence of the antibodies and the occurrence of the transfusion reactions were observed.
CONCLUSION : Anaphylactic NHTRs in these patients with haptoglobin deficiency associated with serum haptoglobin antibodies were suggested to be prevalent in Japan. In addition to IgG antibodies, IgE haptoglobin antibodies detected in the sera of such patients were suggested to play a role in the occurrence of the reactions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Anaphylaxis - epidemiology</subject><subject>Anaphylaxis - etiology</subject><subject>Anaphylaxis - immunology</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibody Specificity</subject><subject>Arteriosclerosis Obliterans - immunology</subject><subject>Arteriosclerosis Obliterans - therapy</subject><subject>Basophils - immunology</subject><subject>Basophils - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Blotting, Western</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Genotype</subject><subject>Haptoglobins - deficiency</subject><subject>Haptoglobins - genetics</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - etiology</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunization</subject><subject>Immunodiffusion</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Isoantibodies - immunology</subject><subject>Japan - epidemiology</subject><subject>Kidney Failure, Chronic - immunology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myelodysplastic Syndromes - immunology</subject><subject>Myelodysplastic Syndromes - therapy</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - immunology</subject><subject>Prevalence</subject><subject>Receptors, IgE - immunology</subject><subject>Registries</subject><subject>Transfusion Reaction</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Urinary Bladder Neoplasms - immunology</subject><subject>Urinary Bladder Neoplasms - therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhi0EYmXjL6DcwF2CT-x8SdxM01oGE2zTJhA31olzvLqkSRa7WvvvcWi1ccnVax0_r209ZiwCngCX-cdVApko4rSqsiTlPE04ByiS7Qs2e9p4yWacS4gBRHrE3ji34oGsOLxmR5CCLLiAGWtPOxyWuxa1tzryI3bObJztu2ikadZ3LrJdtMTB9_dtX9subshYbanz0YB-Shc9Wr-MLu7PI-yakIt_-TDztu4bS-6EvTLYOnp7yGN2Nz-_PfscX35fXJydXsZaClnEjTSUajA8xZo0oJaV4ajTsqwMVFSXNQpTEyddYp6WpHOsoQRqMNO5qDJxzD7szx3G_mFDzqu1dZraFjvqN04VUGW5lFUAyz2ox965kYwaRrvGcaeAq8m0WqlJqJqEqsm0-mtabUP13eGOTb2m5rl4UBuA9wcAncbWBLXaumdOlOF7ch64T3vu0ba0--8HqNubeViEeryvW-dp-1TH8bfKC1Fk6se3hZovfn69-nV9rb6IP6dCq8k</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Shimada, Eiko</creator><creator>Tadokoro, Kenji</creator><creator>Watanabe, Yoshihisa</creator><creator>Ikeda, Kazuyo</creator><creator>Niihara, Hiromi</creator><creator>Maeda, Ikiko</creator><creator>Isa, Kazumi</creator><creator>Moriya, Susumu</creator><creator>Ashida, Takashi</creator><creator>Mitsunaga, Shigeki</creator><creator>Nakajima, Kazunori</creator><creator>Juji, Takeo</creator><general>Blackwell Science Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies</title><author>Shimada, Eiko ; Tadokoro, Kenji ; Watanabe, Yoshihisa ; Ikeda, Kazuyo ; Niihara, Hiromi ; Maeda, Ikiko ; Isa, Kazumi ; Moriya, Susumu ; Ashida, Takashi ; Mitsunaga, Shigeki ; Nakajima, Kazunori ; Juji, Takeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4347-d4fe2c1f02abec1ac49f0ac2889f19eb8ba3fbe0ec8a628ec6ab181eda5c63953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Anaphylaxis - epidemiology</topic><topic>Anaphylaxis - etiology</topic><topic>Anaphylaxis - immunology</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibody Specificity</topic><topic>Arteriosclerosis Obliterans - immunology</topic><topic>Arteriosclerosis Obliterans - therapy</topic><topic>Basophils - immunology</topic><topic>Basophils - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Blotting, Western</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Genotype</topic><topic>Haptoglobins - deficiency</topic><topic>Haptoglobins - genetics</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - etiology</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunization</topic><topic>Immunodiffusion</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Isoantibodies - immunology</topic><topic>Japan - epidemiology</topic><topic>Kidney Failure, Chronic - immunology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myelodysplastic Syndromes - immunology</topic><topic>Myelodysplastic Syndromes - therapy</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - immunology</topic><topic>Prevalence</topic><topic>Receptors, IgE - immunology</topic><topic>Registries</topic><topic>Transfusion Reaction</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Urinary Bladder Neoplasms - immunology</topic><topic>Urinary Bladder Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimada, Eiko</creatorcontrib><creatorcontrib>Tadokoro, Kenji</creatorcontrib><creatorcontrib>Watanabe, Yoshihisa</creatorcontrib><creatorcontrib>Ikeda, Kazuyo</creatorcontrib><creatorcontrib>Niihara, Hiromi</creatorcontrib><creatorcontrib>Maeda, Ikiko</creatorcontrib><creatorcontrib>Isa, Kazumi</creatorcontrib><creatorcontrib>Moriya, Susumu</creatorcontrib><creatorcontrib>Ashida, Takashi</creatorcontrib><creatorcontrib>Mitsunaga, Shigeki</creatorcontrib><creatorcontrib>Nakajima, Kazunori</creatorcontrib><creatorcontrib>Juji, Takeo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimada, Eiko</au><au>Tadokoro, Kenji</au><au>Watanabe, Yoshihisa</au><au>Ikeda, Kazuyo</au><au>Niihara, Hiromi</au><au>Maeda, Ikiko</au><au>Isa, Kazumi</au><au>Moriya, Susumu</au><au>Ashida, Takashi</au><au>Mitsunaga, Shigeki</au><au>Nakajima, Kazunori</au><au>Juji, Takeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2002-06</date><risdate>2002</risdate><volume>42</volume><issue>6</issue><spage>766</spage><epage>773</epage><pages>766-773</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs.
STUDY DESIGN AND METHODS : A total of 4138 cases of voluntarily reported NHTRs in Japan, including 367 cases of immediate‐onset anaphylactic NHTRs, were examined to identify haptoglobin deficiency. Serum haptoglobin IgG and IgE antibodies were determined in haptoglobin‐deficient patients to elucidate the mechanism underlying the transfusion reactions.
RESULTS
: Seven patients with haptoglobin deficiency were identified. Six of them experienced severe and acute NHTRs. Six of them were identified to be homozygous for the
Hp
del
allele of the haptoglobin gene. Both haptoglobin IgG and IgE antibodies were detected in serum samples of all the patients. The stimulative effects of blood transfusion on the production of hap‐ toglobin antibodies in the patients and the relation‐ ship between the presence of the antibodies and the occurrence of the transfusion reactions were observed.
CONCLUSION : Anaphylactic NHTRs in these patients with haptoglobin deficiency associated with serum haptoglobin antibodies were suggested to be prevalent in Japan. In addition to IgG antibodies, IgE haptoglobin antibodies detected in the sera of such patients were suggested to play a role in the occurrence of the reactions.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>12147031</pmid><doi>10.1046/j.1537-2995.2002.00117.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2002-06, Vol.42 (6), p.766-773 |
| issn | 0041-1132 1537-2995 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Alleles Anaphylaxis - epidemiology Anaphylaxis - etiology Anaphylaxis - immunology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibody Specificity Arteriosclerosis Obliterans - immunology Arteriosclerosis Obliterans - therapy Basophils - immunology Basophils - metabolism Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Blotting, Western Child Child, Preschool Comorbidity Enzyme-Linked Immunosorbent Assay Female Gene Deletion Genotype Haptoglobins - deficiency Haptoglobins - genetics Humans Hypersensitivity, Immediate - etiology Hypersensitivity, Immediate - immunology Immunization Immunodiffusion Immunoglobulin E - immunology Immunoglobulin G - immunology Infant Infant, Newborn Isoantibodies - immunology Japan - epidemiology Kidney Failure, Chronic - immunology Kidney Failure, Chronic - therapy Male Mass Screening Mast Cells - immunology Mast Cells - metabolism Medical sciences Middle Aged Myelodysplastic Syndromes - immunology Myelodysplastic Syndromes - therapy Pregnancy Pregnancy Complications - immunology Prevalence Receptors, IgE - immunology Registries Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - therapy |
| title | Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies |
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