High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

Tyrosine kinase inhibitors (TKIs) are promising new agents for specific inhibition of malignant cell growth and metastasis formation. Because most of the TKIs have to reach an intracellular target, specific membrane transporters may significantly modulate their effectiveness. In addition, the hydrop...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular pharmacology 2004-06, Vol.65 (6), p.1485-1495
Hauptverfasser:	Özvegy-Laczka, Csilla, Hegedűs, Tamás, Várady, György, Ujhelly, Olga, Schuetz, John D., Váradi, András, Kéri, György, Őrfi, László, Német, Katalin, Sarkadi, Balázs
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Cell Line Cell Membrane - metabolism Drug Resistance, Multiple - physiology Enzyme Inhibitors - pharmacology HL-60 Cells Humans Insecta - cytology Protein-Tyrosine Kinases - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!