Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960 : Efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates
The present study indicates that the appearance of the B. pertussis harbouring prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively prn1. However, ptxS1A allele of p...
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| Veröffentlicht in: | Vaccine 2004-06, Vol.22 (17), p.2122-2128 |
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| creator | Gzyl, Anna Augustynowicz, Ewa Gniadek, Grzegorz Rabczenko, Daniel Dulny, Grażyna Ślusarczyk, Janusz |
| description | The present study indicates that the appearance of the
B. pertussis harbouring
prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively
prn1. However,
ptxS1A allele of pertussis toxin subunit S1 encoding gene, predominant in the currently isolated
B. pertussis strains, has been found in vaccine strains used for whole-cell pertussis component (wP) production of DTP vaccine in 1960–1978. This outrules the possibility that the appearance of
ptxSIA allele might be related to vaccine pressure driven by non-
ptxS1A vaccine strains used for long-term immunization with wP. Intranasal challenge animal model testing the efficiency of the clearance of
B. pertussis strains harbouring different
ptxS1/
prn allele gene combinations revealed that currently produced DTwP vaccine may not contain adequate
B. pertussis vaccine strains, since isolates with gene variants different from those observed in vaccine strains were eliminated from the lungs of the immunized animals with lower efficiency. |
| doi_str_mv | 10.1016/j.vaccine.2003.12.006 |
| format | Article |
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B. pertussis harbouring
prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively
prn1. However,
ptxS1A allele of pertussis toxin subunit S1 encoding gene, predominant in the currently isolated
B. pertussis strains, has been found in vaccine strains used for whole-cell pertussis component (wP) production of DTP vaccine in 1960–1978. This outrules the possibility that the appearance of
ptxSIA allele might be related to vaccine pressure driven by non-
ptxS1A vaccine strains used for long-term immunization with wP. Intranasal challenge animal model testing the efficiency of the clearance of
B. pertussis strains harbouring different
ptxS1/
prn allele gene combinations revealed that currently produced DTwP vaccine may not contain adequate
B. pertussis vaccine strains, since isolates with gene variants different from those observed in vaccine strains were eliminated from the lungs of the immunized animals with lower efficiency.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2003.12.006</identifier><identifier>PMID: 15149768</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Applied microbiology ; Bacterial diseases ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Outer Membrane Proteins - immunology ; Bacteriology ; Base Sequence ; Biological and medical sciences ; Bordetella pertussis ; Bordetella pertussis - genetics ; Bordetella pertussis - immunology ; Bordetella pertussis - pathogenicity ; Colony Count, Microbial ; Diphtheria-Tetanus-Pertussis Vaccine - genetics ; Diphtheria-Tetanus-Pertussis Vaccine - immunology ; Disease Models, Animal ; DTP vaccine ; Ent and stomatologic bacterial diseases ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, Bacterial ; Human bacterial diseases ; Infectious diseases ; Intranasal model ; Lung - microbiology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; Pertussis Toxin - genetics ; Pertussis Toxin - immunology ; Poland ; Treatment Outcome ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Virulence Factors, Bordetella - genetics ; Virulence Factors, Bordetella - immunology ; Whooping Cough - microbiology ; Whooping Cough - pathology ; Whooping Cough - prevention & control</subject><ispartof>Vaccine, 2004-06, Vol.22 (17), p.2122-2128</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X03008557$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15778596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15149768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gzyl, Anna</creatorcontrib><creatorcontrib>Augustynowicz, Ewa</creatorcontrib><creatorcontrib>Gniadek, Grzegorz</creatorcontrib><creatorcontrib>Rabczenko, Daniel</creatorcontrib><creatorcontrib>Dulny, Grażyna</creatorcontrib><creatorcontrib>Ślusarczyk, Janusz</creatorcontrib><title>Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960 : Efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The present study indicates that the appearance of the
B. pertussis harbouring
prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively
prn1. However,
ptxS1A allele of pertussis toxin subunit S1 encoding gene, predominant in the currently isolated
B. pertussis strains, has been found in vaccine strains used for whole-cell pertussis component (wP) production of DTP vaccine in 1960–1978. This outrules the possibility that the appearance of
ptxSIA allele might be related to vaccine pressure driven by non-
ptxS1A vaccine strains used for long-term immunization with wP. Intranasal challenge animal model testing the efficiency of the clearance of
B. pertussis strains harbouring different
ptxS1/
prn allele gene combinations revealed that currently produced DTwP vaccine may not contain adequate
B. pertussis vaccine strains, since isolates with gene variants different from those observed in vaccine strains were eliminated from the lungs of the immunized animals with lower efficiency.</description><subject>Animals</subject><subject>Applied microbiology</subject><subject>Bacterial diseases</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacteriology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis</subject><subject>Bordetella pertussis - genetics</subject><subject>Bordetella pertussis - immunology</subject><subject>Bordetella pertussis - pathogenicity</subject><subject>Colony Count, Microbial</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - genetics</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - immunology</subject><subject>Disease Models, Animal</subject><subject>DTP vaccine</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Bacterial</subject><subject>Human bacterial diseases</subject><subject>Infectious diseases</subject><subject>Intranasal model</subject><subject>Lung - microbiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Pertussis Toxin - genetics</subject><subject>Pertussis Toxin - immunology</subject><subject>Poland</subject><subject>Treatment Outcome</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Virulence Factors, Bordetella - genetics</subject><subject>Virulence Factors, Bordetella - immunology</subject><subject>Whooping Cough - microbiology</subject><subject>Whooping Cough - pathology</subject><subject>Whooping Cough - prevention & control</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhgMC0aVw4Q7yBW4JduzYSS-IfvAhVaJSi8TN8trjrVdZZ7Gdbfff47SptDcOlg_zzMz7zkxRvCe4Ipjwz-tqp7R2HqoaY1qRusKYPy8WpBW0rBvSvigWuOasZAT_OSpex7jGGDeUdK-KI9IQ1gneLp69u4a_I3gNaKeCU8kNHjmPthDSGKOL6JqgOC5H7xJKw30OKW8OwivwEKeM0yEYSND36iAaU1DORzRGMMgOAaVbQHe3Qw-lzugBOZtB2zCYUWc6l7wa-qlZdJM80nGMTtCFtU67LHiPBvtQ7vzm7uopvXR-zt5sJsl7pFaTgIT0GAL41O-RdkGPfXbqV-i0OpDgYu6XIL4pXlrVR3g7_8fF728XN2c_ystf33-efb0sgdYsldTglpCWUW4JXipGoTOUMW4t5qLrLONLsbRYMMuY5ia_jgOxzIiWt1Z09Lj49Fg3e847iEluXJzGojwMY5SCdE1DMf0vSEQnGsFwBj_M4LjcgJHb4DYq7OXTujPwcQZU1Kq3QXnt4gEnRNt0PHNfHjnI_ncOgowPQwfjAugkzeAkwXI6RLmW8_DldIiS1DIfIv0HMA_XZQ</recordid><startdate>20040602</startdate><enddate>20040602</enddate><creator>Gzyl, Anna</creator><creator>Augustynowicz, Ewa</creator><creator>Gniadek, Grzegorz</creator><creator>Rabczenko, Daniel</creator><creator>Dulny, Grażyna</creator><creator>Ślusarczyk, Janusz</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040602</creationdate><title>Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960 : Efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates</title><author>Gzyl, Anna ; Augustynowicz, Ewa ; Gniadek, Grzegorz ; Rabczenko, Daniel ; Dulny, Grażyna ; Ślusarczyk, Janusz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e324t-3d08118436f10ba43e9d3446ff06799f46b7bf074f44c6d4c696e1f4d7868f793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Applied microbiology</topic><topic>Bacterial diseases</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacteriology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Bordetella pertussis</topic><topic>Bordetella pertussis - genetics</topic><topic>Bordetella pertussis - immunology</topic><topic>Bordetella pertussis - pathogenicity</topic><topic>Colony Count, Microbial</topic><topic>Diphtheria-Tetanus-Pertussis Vaccine - genetics</topic><topic>Diphtheria-Tetanus-Pertussis Vaccine - immunology</topic><topic>Disease Models, Animal</topic><topic>DTP vaccine</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Bacterial</topic><topic>Human bacterial diseases</topic><topic>Infectious diseases</topic><topic>Intranasal model</topic><topic>Lung - microbiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Pertussis Toxin - genetics</topic><topic>Pertussis Toxin - immunology</topic><topic>Poland</topic><topic>Treatment Outcome</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Virulence Factors, Bordetella - genetics</topic><topic>Virulence Factors, Bordetella - immunology</topic><topic>Whooping Cough - microbiology</topic><topic>Whooping Cough - pathology</topic><topic>Whooping Cough - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gzyl, Anna</creatorcontrib><creatorcontrib>Augustynowicz, Ewa</creatorcontrib><creatorcontrib>Gniadek, Grzegorz</creatorcontrib><creatorcontrib>Rabczenko, Daniel</creatorcontrib><creatorcontrib>Dulny, Grażyna</creatorcontrib><creatorcontrib>Ślusarczyk, Janusz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gzyl, Anna</au><au>Augustynowicz, Ewa</au><au>Gniadek, Grzegorz</au><au>Rabczenko, Daniel</au><au>Dulny, Grażyna</au><au>Ślusarczyk, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960 : Efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2004-06-02</date><risdate>2004</risdate><volume>22</volume><issue>17</issue><spage>2122</spage><epage>2128</epage><pages>2122-2128</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The present study indicates that the appearance of the
B. pertussis harbouring
prn2 gene allele variant (not found among clinical isolates before 1990s) may have been induced by long-term vaccination in Poland with DTP-composed vaccine strains presenting exclusively
prn1. However,
ptxS1A allele of pertussis toxin subunit S1 encoding gene, predominant in the currently isolated
B. pertussis strains, has been found in vaccine strains used for whole-cell pertussis component (wP) production of DTP vaccine in 1960–1978. This outrules the possibility that the appearance of
ptxSIA allele might be related to vaccine pressure driven by non-
ptxS1A vaccine strains used for long-term immunization with wP. Intranasal challenge animal model testing the efficiency of the clearance of
B. pertussis strains harbouring different
ptxS1/
prn allele gene combinations revealed that currently produced DTwP vaccine may not contain adequate
B. pertussis vaccine strains, since isolates with gene variants different from those observed in vaccine strains were eliminated from the lungs of the immunized animals with lower efficiency.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15149768</pmid><doi>10.1016/j.vaccine.2003.12.006</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2004-06, Vol.22 (17), p.2122-2128 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71955303 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Applied microbiology Bacterial diseases Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacteriology Base Sequence Biological and medical sciences Bordetella pertussis Bordetella pertussis - genetics Bordetella pertussis - immunology Bordetella pertussis - pathogenicity Colony Count, Microbial Diphtheria-Tetanus-Pertussis Vaccine - genetics Diphtheria-Tetanus-Pertussis Vaccine - immunology Disease Models, Animal DTP vaccine Ent and stomatologic bacterial diseases Female Fundamental and applied biological sciences. Psychology Genes, Bacterial Human bacterial diseases Infectious diseases Intranasal model Lung - microbiology Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Pertussis Toxin - genetics Pertussis Toxin - immunology Poland Treatment Outcome Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virulence Factors, Bordetella - genetics Virulence Factors, Bordetella - immunology Whooping Cough - microbiology Whooping Cough - pathology Whooping Cough - prevention & control |
| title | Sequence variation in pertussis S1 subunit toxin and pertussis genes in Bordetella pertussis strains used for the whole-cell pertussis vaccine produced in Poland since 1960 : Efficiency of the DTwP vaccine-induced immunity against currently circulating B. pertussis isolates |
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