Increased Oxidant-Induced Apoptosis in Cultured Nondividing Human Retinal Pigment Epithelial Cells

To determine whether long-term cultured nondividing human retinal pigment epithelial (hRPE) cells are sensitive to oxidant-induced apoptosis and whether the Fas pathway is involved in the process. Confluent hRPE cells were maintained for 2 to 3 months in the basal medium (DMEM containing 2% fetal bo...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2002-08, Vol.43 (8), p.2546-2553
Hauptverfasser:	Jiang, Shunai, Moriarty, Siobhan E, Grossniklaus, Hans, Nelson, Kasey C, Jones, Dean P, Sternberg, Paul, Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological and medical sciences Blotting, Western Cell Division Cell Survival Cells, Cultured Chromatography, High Pressure Liquid DNA - biosynthesis Fas Ligand Protein fas Receptor - genetics fas Receptor - metabolism Flow Cytometry Glutathione - metabolism Glutathione Disulfide - metabolism Humans Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Ophthalmology Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Retinopathies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism tert-Butylhydroperoxide - pharmacology Up-Regulation
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