Isolation and Structure of a 20,21-Epoxybufenolide Series from “Ch'an Su”

Steroid bufenolides resulting from epoxidation of the 17β-2-pyrone ring of bufadienolides are rare. Five 20,21-epoxybufenolides, namely, 20S,21-epoxyresibufogenin (1), 20R,21-epoxyresibufogenin (2), 3-O-formyl-20S,21-epoxyresibufogenin (3), 3-O-formyl-20R,21-epoxyresibufogenin (4), and 3-oxo-20S,21-...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-07, Vol.65 (7), p.1001-1005
Hauptverfasser:	Kamano, Yoshiaki, Nogawa, Toshihiko, Yamashita, Ayano, Hayashi, Masahiko, Inoue, Masuo, Drašar, Pavel, Pettit, George R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Bufanolides - chemistry Bufanolides - isolation & purification Bufanolides - pharmacology Bufonidae Chromatography, High Pressure Liquid Chromatography, Thin Layer Drug Screening Assays, Antitumor Epoxy Compounds - chemistry Epoxy Compounds - isolation & purification Epoxy Compounds - pharmacology General pharmacology HL-60 Cells - drug effects Humans KB Cells - drug effects Leukemia, Myeloid Magnetic Resonance Spectroscopy Medical sciences Medicine, Chinese Traditional Mice Molecular Conformation Molecular Structure Nasopharyngeal Neoplasms Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Skin - metabolism Spectrophotometry, Infrared Stereoisomerism Tumor Cells, Cultured - drug effects
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