The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression

Apoptosis is an essential process in embryonic tissue remodeling and adult tissue homeostasis. Within the adult hematopoietic system, it allows for tight regulation of hematopoietic cell subsets. Previously, it was shown that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the viabil...

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Veröffentlicht in:	Blood 2004-06, Vol.103 (11), p.4084-4092
Hauptverfasser:	Orelio, Claudia, Harvey, Kirsty N., Miles, Colin, Oostendorp, Robert A.J., van der Horn, Karin, Dzierzak, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Antigens, Ly - genetics Antigens, Ly - metabolism Aorta - embryology Aorta - physiology Apoptosis - physiology Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Survival - physiology Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental General aspects General aspects. Development. Fetal membranes Gestational Age Gonads - embryology Gonads - physiology Hematopoiesis - physiology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Liver - embryology Liver - physiology Male Membrane Proteins - genetics Membrane Proteins - metabolism Mesonephros - embryology Mesonephros - physiology Mice Mice, Inbred C57BL Mice, Inbred CBA Molecular and cellular biology Pregnancy Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-kit - metabolism
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