Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes

CD8+ cytotoxic T lymphocytes (CTLs) contribute to the control of viral infections by recognizing peptides of viral proteins presented by MHC class I molecules on infected cells. Some viruses have developed strategies to evade recognition by CTL. One of these strategies involves antigenic variation i...

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Veröffentlicht in:	Virus research 2004-07, Vol.103 (1), p.97-100
Hauptverfasser:	Rimmelzwaan, G.F, Boon, A.C.M, Voeten, J.T.M, Berkhoff, E.G.M, Fouchier, R.A.M, Osterhaus, A.D.M.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cytotoxic T cells Epitopes Epitopes, T-Lymphocyte - genetics Escape Genetic Variation Humans Influenza Influenza A virus Influenza A virus - immunology Influenza A virus - pathogenicity Leukocytes, Mononuclear - virology Lymphocyte Activation Mutation Nucleoproteins - genetics RNA-Binding Proteins - genetics T-Lymphocytes, Cytotoxic - immunology Variation Viral Core Proteins - genetics
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