Estrogen Receptor-Independent Catechol Estrogen Binding Activity: Protein Binding Studies in Wild-Type, Estrogen Receptor-α KO, and Aromatase KO Mice Tissues

Primary evidence for novel estrogen signaling pathways is based upon well-documented estrogenic responses not inhibited by estrogen receptor antagonists. In addition to 17β-E2, the catechol estrogen 4-hydroxyestradiol (4OHE2) has been shown to elicit biological responses independent of classical est...

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Veröffentlicht in:	Biochemistry (Easton) 2004-06, Vol.43 (21), p.6698-6708
Hauptverfasser:	Philips, Brian J, Ansell, Pete J, Newton, Leslie G, Harada, Nobuhiro, Honda, Shin-Ichiro, Ganjam, Venkataseshu K, Rottinghaus, George E, Welshons, Wade V, Lubahn, Dennis B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase - genetics Aromatase - metabolism Binding, Competitive Estradiol - analogs & derivatives Estradiol - chemical synthesis Estradiol - isolation & purification Estradiol - metabolism Estrogen Antagonists - metabolism Estrogen Receptor alpha Estrogens, Catechol - metabolism Female Hydroxyestrones - chemical synthesis Hydroxyestrones - isolation & purification Hydroxyestrones - metabolism Kidney - metabolism Liver - metabolism Male Mice Mice, Knockout Ovary - metabolism Proteins - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Substrate Specificity Tissue Distribution Uterus - metabolism
Online-Zugang:	Volltext
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