Biomimetic growth of apatite on hydrogen-implanted silicon
Hydrogen in silicon has been widely applied in semiconductor fields. In this paper, the application of hydrogen-implanted silicon wafer in biomedical fields was explored by investigating its bioactivity. Hydrogen implanted silicon wafers were prepared using plasma immersion ion implantation. The sur...
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| Veröffentlicht in: | Biomaterials 2004-11, Vol.25 (25), p.5575-5581 |
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| creator | Liu, Xuanyong Fu, Ricky K.Y. Poon, Ray W.Y. Chen, Peng Chu, Paul K. Ding, Chuanxian |
| description | Hydrogen in silicon has been widely applied in semiconductor fields. In this paper, the application of hydrogen-implanted silicon wafer in biomedical fields was explored by investigating its bioactivity. Hydrogen implanted silicon wafers were prepared using plasma immersion ion implantation. The surface structures of the 1.4×10
17
cm
−2 hydrogen-implanted silicon wafers were investigated using atomic force microscopy and transmission electron microscopy (TEM). The hydrogen depth profiles were acquired by SIMS and the crystal quality of the as-implanted silicon was studied by channeling Rutherford backscattering spectrometry (RBS). The bioactivity of the implanted silicon was evaluated using the biomimetic growth of apatite on its surface after it was soaked in simulated body fluid for a period of time. The TEM, SIMS and RBS results indicate the formation of an amorphous hydrogenated silicon (a-Si:H
x
) layer has been formed on the surface of the hydrogen-implanted silicon wafer. After immersion in SBF for 14 days, bone-like apatite is observed to nucleate and grow on the surface. With longer soaking time, more apatite appeared on the surface of the hydrogen implanted silicon but our control experiments did not reveal any apatite formation on the surface of the un-implanted silicon wafer, hydrogenated crystalline silicon wafer (with hydrogen, but no amorphous surface), or argon-implanted silicon wafer (amorphous surface but without hydrogen). Our results indicated that the bioactivity of silicon wafer can be improved after hydrogen implantation and the formation of the amorphous hydrogenated silicon (a-Si:H
x
) surface also plays a synergistic role to improve the bioactivity. |
| doi_str_mv | 10.1016/j.biomaterials.2004.01.015 |
| format | Article |
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17
cm
−2 hydrogen-implanted silicon wafers were investigated using atomic force microscopy and transmission electron microscopy (TEM). The hydrogen depth profiles were acquired by SIMS and the crystal quality of the as-implanted silicon was studied by channeling Rutherford backscattering spectrometry (RBS). The bioactivity of the implanted silicon was evaluated using the biomimetic growth of apatite on its surface after it was soaked in simulated body fluid for a period of time. The TEM, SIMS and RBS results indicate the formation of an amorphous hydrogenated silicon (a-Si:H
x
) layer has been formed on the surface of the hydrogen-implanted silicon wafer. After immersion in SBF for 14 days, bone-like apatite is observed to nucleate and grow on the surface. With longer soaking time, more apatite appeared on the surface of the hydrogen implanted silicon but our control experiments did not reveal any apatite formation on the surface of the un-implanted silicon wafer, hydrogenated crystalline silicon wafer (with hydrogen, but no amorphous surface), or argon-implanted silicon wafer (amorphous surface but without hydrogen). Our results indicated that the bioactivity of silicon wafer can be improved after hydrogen implantation and the formation of the amorphous hydrogenated silicon (a-Si:H
x
) surface also plays a synergistic role to improve the bioactivity.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2004.01.015</identifier><identifier>PMID: 15159073</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Alpha Particles ; Apatite ; Apatites - analysis ; Apatites - chemical synthesis ; Bioactivity ; Biomimetic Materials - analysis ; Biomimetic Materials - chemical synthesis ; Calcium - analysis ; Carbonates - analysis ; Humans ; Hydrogen - chemistry ; Hydrogen-implanted silicon ; Magnesium - analysis ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; Phosphates - analysis ; Plasma ; Plasma - chemistry ; Potassium - analysis ; Scattering, Radiation ; Silicon - analysis ; Silicon - chemistry ; Sodium - analysis ; Spectrometry, Mass, Secondary Ion ; Spectrometry, X-Ray Emission ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction</subject><ispartof>Biomaterials, 2004-11, Vol.25 (25), p.5575-5581</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c29844616d80e961ecf746fdca883476895b322072aaa8eb3f67857ee8a8f33a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2004.01.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15159073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xuanyong</creatorcontrib><creatorcontrib>Fu, Ricky K.Y.</creatorcontrib><creatorcontrib>Poon, Ray W.Y.</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Chu, Paul K.</creatorcontrib><creatorcontrib>Ding, Chuanxian</creatorcontrib><title>Biomimetic growth of apatite on hydrogen-implanted silicon</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Hydrogen in silicon has been widely applied in semiconductor fields. In this paper, the application of hydrogen-implanted silicon wafer in biomedical fields was explored by investigating its bioactivity. Hydrogen implanted silicon wafers were prepared using plasma immersion ion implantation. The surface structures of the 1.4×10
17
cm
−2 hydrogen-implanted silicon wafers were investigated using atomic force microscopy and transmission electron microscopy (TEM). The hydrogen depth profiles were acquired by SIMS and the crystal quality of the as-implanted silicon was studied by channeling Rutherford backscattering spectrometry (RBS). The bioactivity of the implanted silicon was evaluated using the biomimetic growth of apatite on its surface after it was soaked in simulated body fluid for a period of time. The TEM, SIMS and RBS results indicate the formation of an amorphous hydrogenated silicon (a-Si:H
x
) layer has been formed on the surface of the hydrogen-implanted silicon wafer. After immersion in SBF for 14 days, bone-like apatite is observed to nucleate and grow on the surface. With longer soaking time, more apatite appeared on the surface of the hydrogen implanted silicon but our control experiments did not reveal any apatite formation on the surface of the un-implanted silicon wafer, hydrogenated crystalline silicon wafer (with hydrogen, but no amorphous surface), or argon-implanted silicon wafer (amorphous surface but without hydrogen). Our results indicated that the bioactivity of silicon wafer can be improved after hydrogen implantation and the formation of the amorphous hydrogenated silicon (a-Si:H
x
) surface also plays a synergistic role to improve the bioactivity.</description><subject>Alpha Particles</subject><subject>Apatite</subject><subject>Apatites - analysis</subject><subject>Apatites - chemical synthesis</subject><subject>Bioactivity</subject><subject>Biomimetic Materials - analysis</subject><subject>Biomimetic Materials - chemical synthesis</subject><subject>Calcium - analysis</subject><subject>Carbonates - analysis</subject><subject>Humans</subject><subject>Hydrogen - chemistry</subject><subject>Hydrogen-implanted silicon</subject><subject>Magnesium - analysis</subject><subject>Microscopy, Atomic Force</subject><subject>Microscopy, Electron, Transmission</subject><subject>Phosphates - analysis</subject><subject>Plasma</subject><subject>Plasma - chemistry</subject><subject>Potassium - analysis</subject><subject>Scattering, Radiation</subject><subject>Silicon - analysis</subject><subject>Silicon - chemistry</subject><subject>Sodium - analysis</subject><subject>Spectrometry, Mass, Secondary Ion</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>X-Ray Diffraction</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1LJDEQhoMoOn78BWk8eOsxlc5Xe9v1GwQveg6ZdLVmmO7MJpld_PdmmIH15kBBUfBUvQUPIRdAp0BBXs2nMx8GmzF6u0hTRimfUigl9sgEtNK1aKnYJxMKnNWtBHZEjlOa0zJTzg7JEQgoiGom5Pp3OeUHzN5V7zH8yx9V6Cu7tNlnrMJYfXx2MbzjWPthubBjxq5KfuFdGE_JQV_y8WzbT8jb_d3rzWP9_PLwdPPruXYcRK4dazXnEmSnKZZn0PWKy75zVuuGK6lbMWsYo4pZazXOml4qLRSitrpvGtuckMvN3WUMf1aYshl8crgo32BYJaOgFaCl_BFkmupGgd4NlHwnUAmh2I8gKCG1atfg9QZ0MaQUsTfL6AcbPw1Qs7Zr5ua7XbO2ayiUEmX5fJuymg3Y_V_d6izA7QbA4uOvx2iS8zg67HxEl00X_C45X3c0u4A</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Liu, Xuanyong</creator><creator>Fu, Ricky K.Y.</creator><creator>Poon, Ray W.Y.</creator><creator>Chen, Peng</creator><creator>Chu, Paul K.</creator><creator>Ding, Chuanxian</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>F28</scope><scope>7QQ</scope><scope>JG9</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200411</creationdate><title>Biomimetic growth of apatite on hydrogen-implanted silicon</title><author>Liu, Xuanyong ; Fu, Ricky K.Y. ; Poon, Ray W.Y. ; Chen, Peng ; Chu, Paul K. ; Ding, Chuanxian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-c29844616d80e961ecf746fdca883476895b322072aaa8eb3f67857ee8a8f33a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alpha Particles</topic><topic>Apatite</topic><topic>Apatites - analysis</topic><topic>Apatites - chemical synthesis</topic><topic>Bioactivity</topic><topic>Biomimetic Materials - analysis</topic><topic>Biomimetic Materials - chemical synthesis</topic><topic>Calcium - analysis</topic><topic>Carbonates - analysis</topic><topic>Humans</topic><topic>Hydrogen - chemistry</topic><topic>Hydrogen-implanted silicon</topic><topic>Magnesium - analysis</topic><topic>Microscopy, Atomic Force</topic><topic>Microscopy, Electron, Transmission</topic><topic>Phosphates - analysis</topic><topic>Plasma</topic><topic>Plasma - chemistry</topic><topic>Potassium - analysis</topic><topic>Scattering, Radiation</topic><topic>Silicon - analysis</topic><topic>Silicon - chemistry</topic><topic>Sodium - analysis</topic><topic>Spectrometry, Mass, Secondary Ion</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xuanyong</creatorcontrib><creatorcontrib>Fu, Ricky K.Y.</creatorcontrib><creatorcontrib>Poon, Ray W.Y.</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Chu, Paul K.</creatorcontrib><creatorcontrib>Ding, Chuanxian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Ceramic Abstracts</collection><collection>Materials Research Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xuanyong</au><au>Fu, Ricky K.Y.</au><au>Poon, Ray W.Y.</au><au>Chen, Peng</au><au>Chu, Paul K.</au><au>Ding, Chuanxian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomimetic growth of apatite on hydrogen-implanted silicon</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004-11</date><risdate>2004</risdate><volume>25</volume><issue>25</issue><spage>5575</spage><epage>5581</epage><pages>5575-5581</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Hydrogen in silicon has been widely applied in semiconductor fields. In this paper, the application of hydrogen-implanted silicon wafer in biomedical fields was explored by investigating its bioactivity. Hydrogen implanted silicon wafers were prepared using plasma immersion ion implantation. The surface structures of the 1.4×10
17
cm
−2 hydrogen-implanted silicon wafers were investigated using atomic force microscopy and transmission electron microscopy (TEM). The hydrogen depth profiles were acquired by SIMS and the crystal quality of the as-implanted silicon was studied by channeling Rutherford backscattering spectrometry (RBS). The bioactivity of the implanted silicon was evaluated using the biomimetic growth of apatite on its surface after it was soaked in simulated body fluid for a period of time. The TEM, SIMS and RBS results indicate the formation of an amorphous hydrogenated silicon (a-Si:H
x
) layer has been formed on the surface of the hydrogen-implanted silicon wafer. After immersion in SBF for 14 days, bone-like apatite is observed to nucleate and grow on the surface. With longer soaking time, more apatite appeared on the surface of the hydrogen implanted silicon but our control experiments did not reveal any apatite formation on the surface of the un-implanted silicon wafer, hydrogenated crystalline silicon wafer (with hydrogen, but no amorphous surface), or argon-implanted silicon wafer (amorphous surface but without hydrogen). Our results indicated that the bioactivity of silicon wafer can be improved after hydrogen implantation and the formation of the amorphous hydrogenated silicon (a-Si:H
x
) surface also plays a synergistic role to improve the bioactivity.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>15159073</pmid><doi>10.1016/j.biomaterials.2004.01.015</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biomaterials, 2004-11, Vol.25 (25), p.5575-5581 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alpha Particles Apatite Apatites - analysis Apatites - chemical synthesis Bioactivity Biomimetic Materials - analysis Biomimetic Materials - chemical synthesis Calcium - analysis Carbonates - analysis Humans Hydrogen - chemistry Hydrogen-implanted silicon Magnesium - analysis Microscopy, Atomic Force Microscopy, Electron, Transmission Phosphates - analysis Plasma Plasma - chemistry Potassium - analysis Scattering, Radiation Silicon - analysis Silicon - chemistry Sodium - analysis Spectrometry, Mass, Secondary Ion Spectrometry, X-Ray Emission Spectroscopy, Fourier Transform Infrared X-Ray Diffraction |
| title | Biomimetic growth of apatite on hydrogen-implanted silicon |
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