PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

NF-κB signaling is required for the maintenance of normal B lymphocytes, whereas dysregulated NF-κB activation contributes to B cell lymphomas. The events that regulate NF-κB signaling in B lymphocytes are poorly defined. Here, we demonstrate that PKC-β is specifically required for B cell receptor (...

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Veröffentlicht in:Nature immunology 2002-08, Vol.3 (8), p.780-786
Hauptverfasser: Su, Thomas T., Guo, Beichu, Kawakami, Yuko, Sommer, Karen, Chae, Keun, Humphries, Lisa A., Kato, Roberta M., Kang, Shin, Patrone, Lisa, Wall, Randolph, Teitell, Michael, Leitges, Michael, Kawakami, Toshiaki, Rawlings, David J.
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Sprache:eng
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