Immunisation schedules for non-replicating nasal vaccines can be made simple by allowing time for development of immunological memory

Mice immunised intranasally with multiple doses of outer membrane vesicles (OMVs) from group B meningococci developed antibody responses that depended on the interval between doses. High levels of antibodies in saliva and extracts of faeces were induced within 4 weeks after an OMV vaccine had been g...

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