Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene

The biological analysis of nicastrin (NCSTN) shows its crucial role in γ-cleavage of the amyloid precursor protein. Inhibition of NCSTN demonstrated altered γ-cleavage activity, suggesting its potential implication in Alzheimer's disease (AD). We sequenced the NCSTN gene promoter region and fou...

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Veröffentlicht in:	Neuroscience letters 2004-06, Vol.363 (1), p.49-53
Hauptverfasser:	Orlacchio, Antonio, Kawarai, Toshitaka, Polidoro, Mario, Paterson, Andrew D, Rogaeva, Ekaterina, Orlacchio, Aldo, St George-Hyslop, Peter H, Bernardi, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Alanine - genetics Alleles Alzheimer Disease - genetics Alzheimer's disease Amyloid Precursor Protein Secretases Apolipoproteins E - genetics Association study Biological and medical sciences Cysteine - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology Gene Frequency Glycine - genetics Haplotypes Humans Logistic Models Male Medical sciences Membrane Glycoproteins - genetics Middle Aged Neurology Nicastrin gene Polymorphism, Single Nucleotide Promoter region Promoter Regions, Genetic - genetics Single nucleotide polymorphisms Threonine - genetics Vertebrates: nervous system and sense organs
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