Proton magnetic resonance spectroscopy in children with spastic diplegia
The objective of this prospective study was the application of proton magnetic resonance spectroscopy in children with spastic diplegia (SD) to determine the metabolite profile of SD children in the left basal ganglia, and to assess the relationship of this profile with motor and mental development....
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| Veröffentlicht in: | Neuroscience letters 2004-06, Vol.363 (1), p.62-64 |
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| creator | Kulak, Wojciech Sobaniec, Wojciech Kubas, Bozena Walecki, Jerzy |
| description | The objective of this prospective study was the application of proton magnetic resonance spectroscopy in children with spastic diplegia (SD) to determine the metabolite profile of SD children in the left basal ganglia, and to assess the relationship of this profile with motor and mental development. Patients with SD showed reduced ratios of
N-acetylaspartate (NAA)/creatine (Cr), NAA/choline (Cho), NAA/myo-inositol (mI), Cho/NAA, Cho/Cr and Cho/mI in the basal ganglia compared to a well-matched control group. On the other hand, we noted increased Cr/NAA, Cr/Cho and mI/NAA ratios in the SD patients as compared with controls. NAA/mI ratios were positively correlated with the severity scale of cerebral palsy in SD children. There was also a significant correlation between Cr/NAA and mental retardation. Increased Cr/NAA, Cr/Cho and mI/NAA ratios in SD children may suggest the existence of the compensatory mechanisms in these patients. The NAA/mI ratio could be used as an additional marker of SD severity and Cr/NAA as a marker of the mental retardation. |
| doi_str_mv | 10.1016/j.neulet.2004.03.043 |
| format | Article |
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N-acetylaspartate (NAA)/creatine (Cr), NAA/choline (Cho), NAA/myo-inositol (mI), Cho/NAA, Cho/Cr and Cho/mI in the basal ganglia compared to a well-matched control group. On the other hand, we noted increased Cr/NAA, Cr/Cho and mI/NAA ratios in the SD patients as compared with controls. NAA/mI ratios were positively correlated with the severity scale of cerebral palsy in SD children. There was also a significant correlation between Cr/NAA and mental retardation. Increased Cr/NAA, Cr/Cho and mI/NAA ratios in SD children may suggest the existence of the compensatory mechanisms in these patients. The NAA/mI ratio could be used as an additional marker of SD severity and Cr/NAA as a marker of the mental retardation.</description><subject>Adolescent</subject><subject>Asparagine - analogs & derivatives</subject><subject>Asparagine - metabolism</subject><subject>Basal ganglia</subject><subject>Basal Ganglia - metabolism</subject><subject>Basal Ganglia - pathology</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Case-Control Studies</subject><subject>Cerebral palsy</subject><subject>Cerebral Palsy - diagnosis</subject><subject>Cerebral Palsy - physiopathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Proton magnetic resonance spectroscopy</subject><subject>Protons</subject><subject>Spastic diplegia</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFO3DAQhi1UBFvaN6iqXMot6YzjxPGlUoWgICGVQ3u2HHsMXmWT1M4W8fZ42ZXaE5zmMN-M_vmGsU8IFQK2X9fVSNuBlooDiArqCkR9xFbYSV5KJfk7toIaRFkrAafsfUprAGiwESfsFHOVSskVu76L0zKNxcbcj7QEW0RK02hGS0WayS5xSnaan4owFvYhDC7SWDyG5SF3TdrxLswD3QfzgR17MyT6eKhn7PfV5a-L6_L254-bi--3pRWoltL3iGiEsdahNdI43oBUTdt23Ofo4MF3wnnfgupl33AvQIk2J68JsXV9fcbO93vnOP3ZUlr0JiRLw2BGmrZJS1QN8qZ7E0TZcY5QZ1DsQZuPTZG8nmPYmPikEfROtV7rvWq9U62h1ll1Hvt82L_tN-T-DR3cZuDLATDJmsHHbDWk_zjZyvYl6Lc9R1nb30BRJxsof8CFmD-g3RReT_IMq92ejQ</recordid><startdate>20040603</startdate><enddate>20040603</enddate><creator>Kulak, Wojciech</creator><creator>Sobaniec, Wojciech</creator><creator>Kubas, Bozena</creator><creator>Walecki, Jerzy</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040603</creationdate><title>Proton magnetic resonance spectroscopy in children with spastic diplegia</title><author>Kulak, Wojciech ; Sobaniec, Wojciech ; Kubas, Bozena ; Walecki, Jerzy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-fb111a4accd1ca7ad2507956682f1870f0f84dff609b7b52f409460003e116db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Asparagine - analogs & derivatives</topic><topic>Asparagine - metabolism</topic><topic>Basal ganglia</topic><topic>Basal Ganglia - metabolism</topic><topic>Basal Ganglia - pathology</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Case-Control Studies</topic><topic>Cerebral palsy</topic><topic>Cerebral Palsy - diagnosis</topic><topic>Cerebral Palsy - physiopathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Proton magnetic resonance spectroscopy</topic><topic>Protons</topic><topic>Spastic diplegia</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulak, Wojciech</creatorcontrib><creatorcontrib>Sobaniec, Wojciech</creatorcontrib><creatorcontrib>Kubas, Bozena</creatorcontrib><creatorcontrib>Walecki, Jerzy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulak, Wojciech</au><au>Sobaniec, Wojciech</au><au>Kubas, Bozena</au><au>Walecki, Jerzy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton magnetic resonance spectroscopy in children with spastic diplegia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2004-06-03</date><risdate>2004</risdate><volume>363</volume><issue>1</issue><spage>62</spage><epage>64</epage><pages>62-64</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The objective of this prospective study was the application of proton magnetic resonance spectroscopy in children with spastic diplegia (SD) to determine the metabolite profile of SD children in the left basal ganglia, and to assess the relationship of this profile with motor and mental development. Patients with SD showed reduced ratios of
N-acetylaspartate (NAA)/creatine (Cr), NAA/choline (Cho), NAA/myo-inositol (mI), Cho/NAA, Cho/Cr and Cho/mI in the basal ganglia compared to a well-matched control group. On the other hand, we noted increased Cr/NAA, Cr/Cho and mI/NAA ratios in the SD patients as compared with controls. NAA/mI ratios were positively correlated with the severity scale of cerebral palsy in SD children. There was also a significant correlation between Cr/NAA and mental retardation. Increased Cr/NAA, Cr/Cho and mI/NAA ratios in SD children may suggest the existence of the compensatory mechanisms in these patients. The NAA/mI ratio could be used as an additional marker of SD severity and Cr/NAA as a marker of the mental retardation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15157997</pmid><doi>10.1016/j.neulet.2004.03.043</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2004-06, Vol.363 (1), p.62-64 |
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| subjects | Adolescent Asparagine - analogs & derivatives Asparagine - metabolism Basal ganglia Basal Ganglia - metabolism Basal Ganglia - pathology Biological and medical sciences Birth Weight Case-Control Studies Cerebral palsy Cerebral Palsy - diagnosis Cerebral Palsy - physiopathology Child Child, Preschool Choline - metabolism Creatine - metabolism Female Fundamental and applied biological sciences. Psychology Humans Inositol - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Prospective Studies Proton magnetic resonance spectroscopy Protons Spastic diplegia Vertebrates: nervous system and sense organs |
| title | Proton magnetic resonance spectroscopy in children with spastic diplegia |
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