Expression of Copper-transporting P-type Adenosine Triphosphatase(ATP7B) in Human Hepatocellular Carcinoma
One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the expression...
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| Veröffentlicht in: | Anticancer research 2004-03, Vol.24 (2C), p.1045-1048 |
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| creator | SUGENO, Hidekazu TAKEBAYASHI, Yuji NITTA, Yasutaka FUKUSHIMA, Toshihiko KOYAMA, Yoshihisa INOUE, Norio SEKIKAWA, Kohji OGAWA, Kenji SATO, Yukio TAKENOSHITA, Seiichi HIGASHIMOTO, Masashi OGURA, Yoshito SHIBUKAWA, Goro KANZAKI, Atsuko TERADA, Kunihiko SUGIYAMA, Toshihiro WATANABE, Kumiko KATOH, Ryoji |
| description | One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based
chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin
resistance in vitro. However, the expression of ATP7B has not previously been addressed in human liver and HCC. Our purpose
was to investigate ATP7B expression in human liver and hepatocellular carcinoma and its clinical significance. We retrospectively
examined the expression of ATP7B in primary hepatocellular carcinoma. Immunohistochemical analysis of ATP7B was performed
using a monoclonal antibody against ATP7B in 19 surgically removed hepatocellular carcinomas. A variable degree of cytoplasmic
staining of tumor cells was observed in 21.1% (4/19) of the analyzed carcinomas. ATP7B expression was not observed in normal
hepatic cells. Strong expression of ATP7B was observed in all the analyzed bile ducts. These findings suggest that overexpression
of ATP7B in hepatocellular carcinoma might be associated with unfavorable clinical outcome in patients treated with cisplatin-based
chemotherapy. Further, ATP7B is expressed in bile duct epithelial cells, where it may mediate copper secretion into bile fluid. |
| format | Article |
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chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin
resistance in vitro. However, the expression of ATP7B has not previously been addressed in human liver and HCC. Our purpose
was to investigate ATP7B expression in human liver and hepatocellular carcinoma and its clinical significance. We retrospectively
examined the expression of ATP7B in primary hepatocellular carcinoma. Immunohistochemical analysis of ATP7B was performed
using a monoclonal antibody against ATP7B in 19 surgically removed hepatocellular carcinomas. A variable degree of cytoplasmic
staining of tumor cells was observed in 21.1% (4/19) of the analyzed carcinomas. ATP7B expression was not observed in normal
hepatic cells. Strong expression of ATP7B was observed in all the analyzed bile ducts. These findings suggest that overexpression
of ATP7B in hepatocellular carcinoma might be associated with unfavorable clinical outcome in patients treated with cisplatin-based
chemotherapy. Further, ATP7B is expressed in bile duct epithelial cells, where it may mediate copper secretion into bile fluid.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 15154620</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adenosine Triphosphatases - biosynthesis ; Adenosine Triphosphatases - immunology ; Antibodies, Monoclonal - immunology ; Antibody Specificity ; Bile Ducts - enzymology ; Biological and medical sciences ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - enzymology ; Cation Transport Proteins - biosynthesis ; Cation Transport Proteins - immunology ; Cisplatin - pharmacology ; Copper-transporting ATPases ; Cytoplasmic Granules - enzymology ; Drug Resistance, Neoplasm ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Liver Neoplasms - drug therapy ; Liver Neoplasms - enzymology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Retrospective Studies ; Tumors</subject><ispartof>Anticancer research, 2004-03, Vol.24 (2C), p.1045-1048</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15795430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15154620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUGENO, Hidekazu</creatorcontrib><creatorcontrib>TAKEBAYASHI, Yuji</creatorcontrib><creatorcontrib>NITTA, Yasutaka</creatorcontrib><creatorcontrib>FUKUSHIMA, Toshihiko</creatorcontrib><creatorcontrib>KOYAMA, Yoshihisa</creatorcontrib><creatorcontrib>INOUE, Norio</creatorcontrib><creatorcontrib>SEKIKAWA, Kohji</creatorcontrib><creatorcontrib>OGAWA, Kenji</creatorcontrib><creatorcontrib>SATO, Yukio</creatorcontrib><creatorcontrib>TAKENOSHITA, Seiichi</creatorcontrib><creatorcontrib>HIGASHIMOTO, Masashi</creatorcontrib><creatorcontrib>OGURA, Yoshito</creatorcontrib><creatorcontrib>SHIBUKAWA, Goro</creatorcontrib><creatorcontrib>KANZAKI, Atsuko</creatorcontrib><creatorcontrib>TERADA, Kunihiko</creatorcontrib><creatorcontrib>SUGIYAMA, Toshihiro</creatorcontrib><creatorcontrib>WATANABE, Kumiko</creatorcontrib><creatorcontrib>KATOH, Ryoji</creatorcontrib><title>Expression of Copper-transporting P-type Adenosine Triphosphatase(ATP7B) in Human Hepatocellular Carcinoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based
chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin
resistance in vitro. However, the expression of ATP7B has not previously been addressed in human liver and HCC. Our purpose
was to investigate ATP7B expression in human liver and hepatocellular carcinoma and its clinical significance. We retrospectively
examined the expression of ATP7B in primary hepatocellular carcinoma. Immunohistochemical analysis of ATP7B was performed
using a monoclonal antibody against ATP7B in 19 surgically removed hepatocellular carcinomas. A variable degree of cytoplasmic
staining of tumor cells was observed in 21.1% (4/19) of the analyzed carcinomas. ATP7B expression was not observed in normal
hepatic cells. Strong expression of ATP7B was observed in all the analyzed bile ducts. These findings suggest that overexpression
of ATP7B in hepatocellular carcinoma might be associated with unfavorable clinical outcome in patients treated with cisplatin-based
chemotherapy. Further, ATP7B is expressed in bile duct epithelial cells, where it may mediate copper secretion into bile fluid.</description><subject>Adenosine Triphosphatases - biosynthesis</subject><subject>Adenosine Triphosphatases - immunology</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibody Specificity</subject><subject>Bile Ducts - enzymology</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - enzymology</subject><subject>Cation Transport Proteins - biosynthesis</subject><subject>Cation Transport Proteins - immunology</subject><subject>Cisplatin - pharmacology</subject><subject>Copper-transporting ATPases</subject><subject>Cytoplasmic Granules - enzymology</subject><subject>Drug Resistance, Neoplasm</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - enzymology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkLFOwzAQhi0EoqXwCigLCIZIThzHyVgioEiV6FDm6JJcGleJbexEwNvjiiJY7pZP_333n5B5JPIoFJzRUzKnMaehoJTPyIVze0rTNM_YOZlFPOJJGtM52T9-GovOSa0C3QaFNgZtOFpQzmg7SrULNuH4ZTBYNqi0kwqDrZWm0850MILDu-V2Ix7uA6mC1TSAn2hg1DX2_dSDDQqwtVR6gEty1kLv8Oq4F-Tt6XFbrML16_NLsVyHXZxmY5hiJdoMk5SL3EtyzkVL8wbbtKprhFyIimYRS0RGK9qAB-OmSaus8j_XyGq2ILc_ucbq9wndWA7SHXRAoZ5cKaKcR1RkHrw-glM1YFMaKwewX-VvOx64OQLgauhb30ot3T_uYMjo38VO7roPabF0A_S9j2Ul2Dgp46KMaMLZN4ROfJA</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>SUGENO, Hidekazu</creator><creator>TAKEBAYASHI, Yuji</creator><creator>NITTA, Yasutaka</creator><creator>FUKUSHIMA, Toshihiko</creator><creator>KOYAMA, Yoshihisa</creator><creator>INOUE, Norio</creator><creator>SEKIKAWA, Kohji</creator><creator>OGAWA, Kenji</creator><creator>SATO, Yukio</creator><creator>TAKENOSHITA, Seiichi</creator><creator>HIGASHIMOTO, Masashi</creator><creator>OGURA, Yoshito</creator><creator>SHIBUKAWA, Goro</creator><creator>KANZAKI, Atsuko</creator><creator>TERADA, Kunihiko</creator><creator>SUGIYAMA, Toshihiro</creator><creator>WATANABE, Kumiko</creator><creator>KATOH, Ryoji</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Expression of Copper-transporting P-type Adenosine Triphosphatase(ATP7B) in Human Hepatocellular Carcinoma</title><author>SUGENO, Hidekazu ; TAKEBAYASHI, Yuji ; NITTA, Yasutaka ; FUKUSHIMA, Toshihiko ; KOYAMA, Yoshihisa ; INOUE, Norio ; SEKIKAWA, Kohji ; OGAWA, Kenji ; SATO, Yukio ; TAKENOSHITA, Seiichi ; HIGASHIMOTO, Masashi ; OGURA, Yoshito ; SHIBUKAWA, Goro ; KANZAKI, Atsuko ; TERADA, Kunihiko ; SUGIYAMA, Toshihiro ; WATANABE, Kumiko ; KATOH, Ryoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-6eb7f8e465795465557f09def6bccea977b08134780b0dae462dd6b8b530ce3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine Triphosphatases - biosynthesis</topic><topic>Adenosine Triphosphatases - immunology</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibody Specificity</topic><topic>Bile Ducts - enzymology</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - enzymology</topic><topic>Cation Transport Proteins - biosynthesis</topic><topic>Cation Transport Proteins - immunology</topic><topic>Cisplatin - pharmacology</topic><topic>Copper-transporting ATPases</topic><topic>Cytoplasmic Granules - enzymology</topic><topic>Drug Resistance, Neoplasm</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - enzymology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUGENO, Hidekazu</creatorcontrib><creatorcontrib>TAKEBAYASHI, Yuji</creatorcontrib><creatorcontrib>NITTA, Yasutaka</creatorcontrib><creatorcontrib>FUKUSHIMA, Toshihiko</creatorcontrib><creatorcontrib>KOYAMA, Yoshihisa</creatorcontrib><creatorcontrib>INOUE, Norio</creatorcontrib><creatorcontrib>SEKIKAWA, Kohji</creatorcontrib><creatorcontrib>OGAWA, Kenji</creatorcontrib><creatorcontrib>SATO, Yukio</creatorcontrib><creatorcontrib>TAKENOSHITA, Seiichi</creatorcontrib><creatorcontrib>HIGASHIMOTO, Masashi</creatorcontrib><creatorcontrib>OGURA, Yoshito</creatorcontrib><creatorcontrib>SHIBUKAWA, Goro</creatorcontrib><creatorcontrib>KANZAKI, Atsuko</creatorcontrib><creatorcontrib>TERADA, Kunihiko</creatorcontrib><creatorcontrib>SUGIYAMA, Toshihiro</creatorcontrib><creatorcontrib>WATANABE, Kumiko</creatorcontrib><creatorcontrib>KATOH, Ryoji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUGENO, Hidekazu</au><au>TAKEBAYASHI, Yuji</au><au>NITTA, Yasutaka</au><au>FUKUSHIMA, Toshihiko</au><au>KOYAMA, Yoshihisa</au><au>INOUE, Norio</au><au>SEKIKAWA, Kohji</au><au>OGAWA, Kenji</au><au>SATO, Yukio</au><au>TAKENOSHITA, Seiichi</au><au>HIGASHIMOTO, Masashi</au><au>OGURA, Yoshito</au><au>SHIBUKAWA, Goro</au><au>KANZAKI, Atsuko</au><au>TERADA, Kunihiko</au><au>SUGIYAMA, Toshihiro</au><au>WATANABE, Kumiko</au><au>KATOH, Ryoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Copper-transporting P-type Adenosine Triphosphatase(ATP7B) in Human Hepatocellular Carcinoma</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>24</volume><issue>2C</issue><spage>1045</spage><epage>1048</epage><pages>1045-1048</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based
chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin
resistance in vitro. However, the expression of ATP7B has not previously been addressed in human liver and HCC. Our purpose
was to investigate ATP7B expression in human liver and hepatocellular carcinoma and its clinical significance. We retrospectively
examined the expression of ATP7B in primary hepatocellular carcinoma. Immunohistochemical analysis of ATP7B was performed
using a monoclonal antibody against ATP7B in 19 surgically removed hepatocellular carcinomas. A variable degree of cytoplasmic
staining of tumor cells was observed in 21.1% (4/19) of the analyzed carcinomas. ATP7B expression was not observed in normal
hepatic cells. Strong expression of ATP7B was observed in all the analyzed bile ducts. These findings suggest that overexpression
of ATP7B in hepatocellular carcinoma might be associated with unfavorable clinical outcome in patients treated with cisplatin-based
chemotherapy. Further, ATP7B is expressed in bile duct epithelial cells, where it may mediate copper secretion into bile fluid.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>15154620</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adenosine Triphosphatases - biosynthesis Adenosine Triphosphatases - immunology Antibodies, Monoclonal - immunology Antibody Specificity Bile Ducts - enzymology Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Cation Transport Proteins - biosynthesis Cation Transport Proteins - immunology Cisplatin - pharmacology Copper-transporting ATPases Cytoplasmic Granules - enzymology Drug Resistance, Neoplasm Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Retrospective Studies Tumors |
| title | Expression of Copper-transporting P-type Adenosine Triphosphatase(ATP7B) in Human Hepatocellular Carcinoma |
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