Should the post‐coital test (PCT) be part of the routine fertility work‐up?
BACKGROUND: This study aimed to determine whether medical history and semen analysis can predict the result of the post‐coital test (PCT). METHODS: A previously reported data set of Dutch patients collected between 1985 and 1993 was used. Our study was limited to just patients with an ovulatory cycl...
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| Veröffentlicht in: | Human reproduction (Oxford) 2004-06, Vol.19 (6), p.1373-1379 |
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| creator | van der Steeg, Jan W. Steures, Pieternel Eijkemans, Marinus J.C. Habbema, J. Dik van der Veen, Fulco Bossuyt, Patrick M.M. Hompes, Peter G.A. Mol, Ben W.J. |
| description | BACKGROUND: This study aimed to determine whether medical history and semen analysis can predict the result of the post‐coital test (PCT). METHODS: A previously reported data set of Dutch patients collected between 1985 and 1993 was used. Our study was limited to just patients with an ovulatory cycle. Data were complete for medical history, semen analysis and PCT. We performed logistic regression analysis to evaluate whether these factors could predict the result of the PCT (PCT model). Furthermore, we evaluated the additional contribution of the PCT in the prediction of treatment‐independent pregnancy (pregnancy model). RESULTS: Thirty‐four percent (179 out of 522) had an abnormal PCT. The PCT model contained previous pregnancy [odds ratio (OR) 2.1; 95% confidence interval (CI) 1.3–3.5], semen volume (OR 0.88; 95% CI 0.77–0.99), sperm concentration (OR 0.96; 95% CI 0.94–0.97), sperm motility (OR 0.97; 95% CI 0.96–0.98) and sperm morphology (OR 2.7; 95% CI 1.2–6.8). The area under the ROC curve of the model was 0.81. In the pregnancy model, the result of the actual PCT could be replaced by the predicted result of the PCT model in about half of the couples, without compromising its predictive capacity. CONCLUSION: The medical history and semen analysis can predict the result of the PCT in ∼50% of the subfertile couples with a regular cycle, without compromising its potential to predict pregnancy. |
| doi_str_mv | 10.1093/humrep/deh230 |
| format | Article |
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Dik ; van der Veen, Fulco ; Bossuyt, Patrick M.M. ; Hompes, Peter G.A. ; Mol, Ben W.J.</creator><creatorcontrib>van der Steeg, Jan W. ; Steures, Pieternel ; Eijkemans, Marinus J.C. ; Habbema, J. Dik ; van der Veen, Fulco ; Bossuyt, Patrick M.M. ; Hompes, Peter G.A. ; Mol, Ben W.J.</creatorcontrib><description>BACKGROUND: This study aimed to determine whether medical history and semen analysis can predict the result of the post‐coital test (PCT). METHODS: A previously reported data set of Dutch patients collected between 1985 and 1993 was used. Our study was limited to just patients with an ovulatory cycle. Data were complete for medical history, semen analysis and PCT. We performed logistic regression analysis to evaluate whether these factors could predict the result of the PCT (PCT model). Furthermore, we evaluated the additional contribution of the PCT in the prediction of treatment‐independent pregnancy (pregnancy model). RESULTS: Thirty‐four percent (179 out of 522) had an abnormal PCT. The PCT model contained previous pregnancy [odds ratio (OR) 2.1; 95% confidence interval (CI) 1.3–3.5], semen volume (OR 0.88; 95% CI 0.77–0.99), sperm concentration (OR 0.96; 95% CI 0.94–0.97), sperm motility (OR 0.97; 95% CI 0.96–0.98) and sperm morphology (OR 2.7; 95% CI 1.2–6.8). The area under the ROC curve of the model was 0.81. In the pregnancy model, the result of the actual PCT could be replaced by the predicted result of the PCT model in about half of the couples, without compromising its predictive capacity. CONCLUSION: The medical history and semen analysis can predict the result of the PCT in ∼50% of the subfertile couples with a regular cycle, without compromising its potential to predict pregnancy.</description><identifier>ISSN: 0268-1161</identifier><identifier>ISSN: 1460-2350</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deh230</identifier><identifier>PMID: 15070874</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Coitus ; Confidence Intervals ; Diagnostic Tests, Routine ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infertility - diagnosis ; Logistic Models ; Male ; Medical Records ; Middle Aged ; model/PCT/pregnancy/prognosis/subfertility ; Odds Ratio ; Predictive Value of Tests ; Pregnancy ; Retrospective Studies ; ROC Curve ; Semen ; Sperm Count ; Sperm Motility ; Spermatozoa - cytology</subject><ispartof>Human reproduction (Oxford), 2004-06, Vol.19 (6), p.1373-1379</ispartof><rights>European Society of Human Reproduction and Embryology 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b2215beef7d42bcabc9d0988586a2ee41f48e3d6c91a9827eda585b12895fc253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15869827$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15070874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Steeg, Jan W.</creatorcontrib><creatorcontrib>Steures, Pieternel</creatorcontrib><creatorcontrib>Eijkemans, Marinus J.C.</creatorcontrib><creatorcontrib>Habbema, J. Dik</creatorcontrib><creatorcontrib>van der Veen, Fulco</creatorcontrib><creatorcontrib>Bossuyt, Patrick M.M.</creatorcontrib><creatorcontrib>Hompes, Peter G.A.</creatorcontrib><creatorcontrib>Mol, Ben W.J.</creatorcontrib><title>Should the post‐coital test (PCT) be part of the routine fertility work‐up?</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: This study aimed to determine whether medical history and semen analysis can predict the result of the post‐coital test (PCT). METHODS: A previously reported data set of Dutch patients collected between 1985 and 1993 was used. Our study was limited to just patients with an ovulatory cycle. Data were complete for medical history, semen analysis and PCT. We performed logistic regression analysis to evaluate whether these factors could predict the result of the PCT (PCT model). Furthermore, we evaluated the additional contribution of the PCT in the prediction of treatment‐independent pregnancy (pregnancy model). RESULTS: Thirty‐four percent (179 out of 522) had an abnormal PCT. The PCT model contained previous pregnancy [odds ratio (OR) 2.1; 95% confidence interval (CI) 1.3–3.5], semen volume (OR 0.88; 95% CI 0.77–0.99), sperm concentration (OR 0.96; 95% CI 0.94–0.97), sperm motility (OR 0.97; 95% CI 0.96–0.98) and sperm morphology (OR 2.7; 95% CI 1.2–6.8). The area under the ROC curve of the model was 0.81. In the pregnancy model, the result of the actual PCT could be replaced by the predicted result of the PCT model in about half of the couples, without compromising its predictive capacity. CONCLUSION: The medical history and semen analysis can predict the result of the PCT in ∼50% of the subfertile couples with a regular cycle, without compromising its potential to predict pregnancy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Coitus</subject><subject>Confidence Intervals</subject><subject>Diagnostic Tests, Routine</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infertility - diagnosis</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical Records</subject><subject>Middle Aged</subject><subject>model/PCT/pregnancy/prognosis/subfertility</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Semen</subject><subject>Sperm Count</subject><subject>Sperm Motility</subject><subject>Spermatozoa - cytology</subject><issn>0268-1161</issn><issn>1460-2350</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1O3DAQB3CrApUt5cgVRUit6CFgO7HjnFC1alkkBEiAirhYjjPRBrLr4A8Btz5Cn5EnqZdEBXHpyZb8m_HMH6FtgvcJLrODeVhY6A9qmNMMf0ATknOc0ozhNTTBlIuUEE420CfnbjGOV8E_og3CcIFFkU_Q2cXchK5O_ByS3jj__PuPNq1XXeLB-WTvfHr5Lanim7I-Mc2Lsyb4dglJA9a3Xeufkgdj72Jl6A8_o_VGdQ62xnMTXf38cTmdpSdnR8fT7yepzhn3aUUpYRVAU9Q5rbSqdFnjUggmuKIAOWlyAVnNdUlUKWgBtWKCVYSKkjWasmwTfR369tbchziqXLROQ9epJZjgZEFKFtdfwd138NYEu4yzSUqIEJmgNKJ0QNoa5yw0srftQtknSbBcxSyHmOUQc_Q7Y9NQLaB-1WOuEXwZgXJadY1VS926N07w1VrR7Q3OhP6_f44zts7D4z-s7J3kRVYwObu-kRfT2XlByan8lf0F6qGlSQ</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>van der Steeg, Jan W.</creator><creator>Steures, Pieternel</creator><creator>Eijkemans, Marinus J.C.</creator><creator>Habbema, J. Dik</creator><creator>van der Veen, Fulco</creator><creator>Bossuyt, Patrick M.M.</creator><creator>Hompes, Peter G.A.</creator><creator>Mol, Ben W.J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Should the post‐coital test (PCT) be part of the routine fertility work‐up?</title><author>van der Steeg, Jan W. ; Steures, Pieternel ; Eijkemans, Marinus J.C. ; Habbema, J. Dik ; van der Veen, Fulco ; Bossuyt, Patrick M.M. ; Hompes, Peter G.A. ; Mol, Ben W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b2215beef7d42bcabc9d0988586a2ee41f48e3d6c91a9827eda585b12895fc253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Coitus</topic><topic>Confidence Intervals</topic><topic>Diagnostic Tests, Routine</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infertility - diagnosis</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical Records</topic><topic>Middle Aged</topic><topic>model/PCT/pregnancy/prognosis/subfertility</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Semen</topic><topic>Sperm Count</topic><topic>Sperm Motility</topic><topic>Spermatozoa - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Steeg, Jan W.</creatorcontrib><creatorcontrib>Steures, Pieternel</creatorcontrib><creatorcontrib>Eijkemans, Marinus J.C.</creatorcontrib><creatorcontrib>Habbema, J. Dik</creatorcontrib><creatorcontrib>van der Veen, Fulco</creatorcontrib><creatorcontrib>Bossuyt, Patrick M.M.</creatorcontrib><creatorcontrib>Hompes, Peter G.A.</creatorcontrib><creatorcontrib>Mol, Ben W.J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Steeg, Jan W.</au><au>Steures, Pieternel</au><au>Eijkemans, Marinus J.C.</au><au>Habbema, J. Dik</au><au>van der Veen, Fulco</au><au>Bossuyt, Patrick M.M.</au><au>Hompes, Peter G.A.</au><au>Mol, Ben W.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Should the post‐coital test (PCT) be part of the routine fertility work‐up?</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>19</volume><issue>6</issue><spage>1373</spage><epage>1379</epage><pages>1373-1379</pages><issn>0268-1161</issn><issn>1460-2350</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: This study aimed to determine whether medical history and semen analysis can predict the result of the post‐coital test (PCT). METHODS: A previously reported data set of Dutch patients collected between 1985 and 1993 was used. Our study was limited to just patients with an ovulatory cycle. Data were complete for medical history, semen analysis and PCT. We performed logistic regression analysis to evaluate whether these factors could predict the result of the PCT (PCT model). Furthermore, we evaluated the additional contribution of the PCT in the prediction of treatment‐independent pregnancy (pregnancy model). RESULTS: Thirty‐four percent (179 out of 522) had an abnormal PCT. The PCT model contained previous pregnancy [odds ratio (OR) 2.1; 95% confidence interval (CI) 1.3–3.5], semen volume (OR 0.88; 95% CI 0.77–0.99), sperm concentration (OR 0.96; 95% CI 0.94–0.97), sperm motility (OR 0.97; 95% CI 0.96–0.98) and sperm morphology (OR 2.7; 95% CI 1.2–6.8). The area under the ROC curve of the model was 0.81. In the pregnancy model, the result of the actual PCT could be replaced by the predicted result of the PCT model in about half of the couples, without compromising its predictive capacity. CONCLUSION: The medical history and semen analysis can predict the result of the PCT in ∼50% of the subfertile couples with a regular cycle, without compromising its potential to predict pregnancy.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15070874</pmid><doi>10.1093/humrep/deh230</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 2004-06, Vol.19 (6), p.1373-1379 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Coitus Confidence Intervals Diagnostic Tests, Routine Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Infertility - diagnosis Logistic Models Male Medical Records Middle Aged model/PCT/pregnancy/prognosis/subfertility Odds Ratio Predictive Value of Tests Pregnancy Retrospective Studies ROC Curve Semen Sperm Count Sperm Motility Spermatozoa - cytology |
| title | Should the post‐coital test (PCT) be part of the routine fertility work‐up? |
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