X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase

The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis . Apo enzyme crystals were ana...

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Veröffentlicht in:	Nature Structural Biology 2002-08, Vol.9 (8), p.591-596
Hauptverfasser:	Kim, Misa, Okajima, Toshihide, Kishishita, Seiichiro, Yoshimura, Megumi, Kawamori, Asako, Tanizawa, Katsuyuki, Yamaguchi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - chemistry Amine Oxidase (Copper-Containing) - metabolism Apoenzymes - chemistry Apoenzymes - metabolism Arthrobacter - enzymology Biochemistry Biological Microscopy Biomedical and Life Sciences Catalytic Domain Copper Crystallography Crystallography, X-Ray Crystals Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - chemistry Dihydroxyphenylalanine - metabolism Electron Spin Resonance Spectroscopy letter Life Sciences Membrane Biology Models, Molecular Protein Conformation Protein Structure Spectrophotometry Static Electricity
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