Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?
The functional consequences of recognition of antigen displayed by the endothelium during T cell extravasation in the development of an immune response have been a matter of debate for a long time. Most investigations have focused on the induction of proliferative responses and cytokine production b...
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| Veröffentlicht in: | Immunology Letters 2004-05, Vol.93 (2), p.109-113 |
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| container_end_page | 113 |
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| container_title | Immunology Letters |
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| creator | Marelli-Berg, Federica M Jarmin, Sarah J |
| description | The functional consequences of recognition of antigen displayed by the endothelium during T cell extravasation in the development of an immune response have been a matter of debate for a long time. Most investigations have focused on the induction of proliferative responses and cytokine production by T cells. In parallel, endothelial cells have been shown to express costimulatory molecules with positive and negative regulatory effects on T cell responses. Recent studies have provided an alternative view of the antigen presenting cell function of endothelial cells, suggesting that cognate recognition of the endothelium by trafficking T cells is a key event in selecting the migration of antigen-specific lymphocytes into the site of inflammation. |
| doi_str_mv | 10.1016/j.imlet.2004.03.014 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology Letters, 2004-05, Vol.93 (2), p.109-113 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigen presentation Antigen Presentation - immunology Antigens, CD - immunology B7-1 Antigen - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Division - immunology Cell Movement - immunology Cell Movement - physiology Endothelial cells Endothelium - immunology Humans Species Specificity T lymphocyte T-Lymphocytes - immunology T-Lymphocytes - physiology Trafficking |
| title | Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking? |
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