Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats

The effects of zanapezil (TAK-147) and donepezil (E2020) on extracellular acetylcholine (ACh) levels were investigated by HPLC-microdialysis of ventral hippocampus (VH) in freely moving intact rats. The results showed that the basal ACh release rate in the VH is 116.7±12.4 to 158.4±22.86 fmol/20 μl....

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Veröffentlicht in:	Brain research 2004-06, Vol.1012 (1), p.169-176
Hauptverfasser:	Hatip-Al-Khatib, Izzettin, Takashi, Arai, Egashira, Nobuaki, Iwasaki, Katsunori, Fujiwara, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - metabolism Alzheimer's disease Animals Benzazepines - pharmacology Biological and medical sciences Cholinergic system Donepezil Dose-Response Relationship, Drug E2020 Extracellular Fluid - drug effects Extracellular Fluid - metabolism Hippocampus - blood supply Hippocampus - drug effects Hippocampus - metabolism Indans - pharmacology Male Medical sciences Microdialysis Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperidines - pharmacology Rats Rats, Wistar Ventral hippocampus Zanapezil
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