Genomic Effects of Polyamide/DNA Interactions on mRNA Expression

Here we characterize the biological activity of a hairpin polyamide 1 that inhibits binding of the minor-groove transcription factor LEF-1, constitutively expressed in colon cancers. Genome-wide analysis of mRNA expression in DLD1 colon cancer cells treated with 1 reveals that a limited number of ge...

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Veröffentlicht in:	Chemistry & biology 2002-07, Vol.9 (7), p.821-827
Hauptverfasser:	Supekova, Lubica, Pezacki, John Paul, Su, Andrew I., Loweth, Colin J., Riedl, Rainer, Geierstanger, Bernhard, Schultz, Peter G., Wemmer, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Calreticulin - genetics Colonic Neoplasms Databases, Genetic DNA - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Down-Regulation - genetics Down-Regulation - physiology Electrophoretic Mobility Shift Assay Genes, bcl-1 - genetics Humans Lymphoid Enhancer-Binding Factor 1 Microscopy, Fluorescence Nucleic Acid Conformation Nylons - chemistry Nylons - metabolism Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic RNA, Messenger - biosynthesis Transcription Factors - analysis Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - physiology Tumor Cells, Cultured
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