Unique CYP2D6 activity distribution and genotype‐phenotype discordance in black Americans

Background Although CYP2D6 has been studied extensively in differentpopulation groups, relatively little is known for black Americans. Methods CYP2D6 activity was assessed with dextromethorphan in 283 black American subjects and correlated with their genotype (2D6*2 to *12, 2D6*14, 2D6*15, 2D6*17, 2...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2002-07, Vol.72 (1), p.76-89
Hauptverfasser:	Gaedigk, Andrea, Bradford, L. DiAnne, Marcucci, Kenda A., Leeder, J. Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Animals Antitussive Agents Biological and medical sciences Black or African American Black People - genetics COS Cells Cytochrome P-450 CYP2D6 - genetics Dextromethorphan DNA Primers Female Gene Frequency General pharmacology Genotype Humans Kinetics Male Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Polymorphism, Genetic United States White People
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