NK cell depletion diminish tumour-specific B cell responses

Natural killer (NK) cells can exercise immediate cytotoxicity against malignant cells and thus far modulate the development of tumour directed T cell immunity. To investigate the impact of NK cells on the development of tumour directed B cell immunity mice were immunised with IMR5-75 human neuroblas...

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Veröffentlicht in:	Immunology letters 2004-05, Vol.93 (2), p.205-210
Hauptverfasser:	Jensen, Markus, Tawadros, Samir, Sedlacek, Hans-Harald, Schultze, Joachim L, Berthold, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Antibodies - pharmacology Antibody Formation - drug effects Antibody Formation - immunology B cells B-Lymphocytes - immunology Cancer Cell Line, Tumor Cell Transplantation Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology Enzyme-Linked Immunosorbent Assay Flow Cytometry G(M1) Ganglioside - immunology Gangliosides - immunology Humans Immunity, Innate - drug effects Immunity, Innate - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin Isotypes - blood Immunoglobulin Isotypes - immunology Immunotherapy Innate immunity Killer Cells, Natural - immunology Mice Mice, Inbred C57BL Mice, SCID Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology NK cells Vaccination Xenograft Model Antitumor Assays
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