Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice

Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because s...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-05, Vol.109 (20), p.2448-2453
Hauptverfasser:	CHYU, Kuang-Yuh, BABBIDGE, Stephanie M, XIAONING ZHAO, DANDILLAYA, Ram, RIETVELD, Anton G, YANO, Juliana, DIMAYUGA, Paul, CERCEK, Bojan, SHAH, Prediman K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - analysis Antioxidants - therapeutic use Apolipoproteins E - genetics Arteriosclerosis - drug therapy Arteriosclerosis - metabolism Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Camellia sinensis - chemistry Cardiology. Vascular system Cardiovascular system Carotid Artery Diseases - drug therapy Carotid Artery Diseases - pathology Catechin - analogs & derivatives Catechin - blood Catechin - therapeutic use Cell Division Cholesterol - blood Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Male Medical sciences Mice Mice, Knockout Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Pharmacology. Drug treatments Transcription Factor AP-1 - metabolism Vasodilator agents. Cerebral vasodilators
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