Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins

To kill invading bacteria, viruses, and fungi, phagocytes secrete hydrogen peroxide (H 2O 2) and the heme enzyme myeloperoxidase. We have explored the possibility that myeloperoxidase might use H 2O 2 to convert L-tyrosine to tyrosyl radical. Activated human neutrophils and monocytes used the system...

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