Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles: Differential Role in Vasoconstriction

Sphingosine 1-phosphate (S1P), a lipid released from activated platelets, influences physiological processes in the cardiovascular system via activation of the endothelial differentiation gene (EDG/S1P) family of 7 transmembrane G protein–coupled receptors. In cultured vascular smooth muscle (VSM) c...

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Veröffentlicht in:	Circulation research 2002-07, Vol.91 (2), p.151-157
Hauptverfasser:	Coussin, Frederic, Scott, Roderick H, Wise, Alan, Nixon, Graeme F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - drug effects Aorta - physiology Biological and medical sciences Calcium - metabolism Calcium Signaling Cells, Cultured Cerebral Arteries - cytology Cerebral Arteries - drug effects Cerebral Arteries - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Culture Techniques Cytoplasm - metabolism Electric Conductivity Fundamental and applied biological sciences. Psychology Heterotrimeric GTP-Binding Proteins - metabolism Lysophospholipids Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Rats Rats, Sprague-Dawley Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Lysophospholipid rhoA GTP-Binding Protein - metabolism Signal Transduction Sphingosine - analogs & derivatives Sphingosine - pharmacology Vasoconstriction Vasoconstrictor Agents - pharmacology Vertebrates: nervous system and sense organs
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