Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure
Some patients with chronic heart failure have intraventricular conduction delays, which cause asynchronous contraction of the left ventricle. This large clinical trial confirmed that biventricular pacing to restore synchronous contraction has significant benefits in such patients. The addition of an...
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| Veröffentlicht in: | The New England journal of medicine 2004-05, Vol.350 (21), p.2140-2150 |
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| container_title | The New England journal of medicine |
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| creator | Bristow, Michael R Saxon, Leslie A Boehmer, John Krueger, Steven Kass, David A De Marco, Teresa Carson, Peter DiCarlo, Lorenzo DeMets, David White, Bill G DeVries, Dale W Feldman, Arthur M |
| description | Some patients with chronic heart failure have intraventricular conduction delays, which cause asynchronous contraction of the left ventricle. This large clinical trial confirmed that biventricular pacing to restore synchronous contraction has significant benefits in such patients. The addition of an implantable defibrillator further reduces mortality.
Resynchronization therapy may have clinical benefit, especially when combined with an implantable defibrillator.
Intraventricular conduction delays are associated with dyssynchronous left ventricular contraction caused by regional delays in the electrical activation of the chamber.
1
,
2
This phenomenon, which occurs in 15 to 30 percent
3
–
5
of patients with heart failure due to dilated cardiomyopathy, reduces systolic function and increases systolic volume.
6
–
8
In patients with primary or secondary dilated cardiomyopathies characterized by intraventricular conduction delays, biventricular stimulation synchronizes the activation of the intraventricular septum and left ventricular free wall and thus improves left ventricular systolic function.
6
–
8
In short-term studies, cardiac-resynchronization therapy in the form of biventricular stimulation improved symptoms,
9
–
12
improved the . . . |
| doi_str_mv | 10.1056/NEJMoa032423 |
| format | Article |
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Resynchronization therapy may have clinical benefit, especially when combined with an implantable defibrillator.
Intraventricular conduction delays are associated with dyssynchronous left ventricular contraction caused by regional delays in the electrical activation of the chamber.
1
,
2
This phenomenon, which occurs in 15 to 30 percent
3
–
5
of patients with heart failure due to dilated cardiomyopathy, reduces systolic function and increases systolic volume.
6
–
8
In patients with primary or secondary dilated cardiomyopathies characterized by intraventricular conduction delays, biventricular stimulation synchronizes the activation of the intraventricular septum and left ventricular free wall and thus improves left ventricular systolic function.
6
–
8
In short-term studies, cardiac-resynchronization therapy in the form of biventricular stimulation improved symptoms,
9
–
12
improved the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa032423</identifier><identifier>PMID: 15152059</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Aged ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Biological and medical sciences ; Cardiology. Vascular system ; Chronic Disease ; Combined Modality Therapy ; Defibrillators, Implantable ; Diuretics - therapeutic use ; Female ; General aspects ; Heart ; Heart failure ; Heart Failure - complications ; Heart Failure - drug therapy ; Heart Failure - mortality ; Heart Failure - therapy ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hospitalization ; Humans ; Male ; Medical sciences ; Pacemaker, Artificial ; Risk ; Spironolactone - therapeutic use ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - therapy</subject><ispartof>The New England journal of medicine, 2004-05, Vol.350 (21), p.2140-2150</ispartof><rights>Copyright © 2004 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-be00d5c6515e24c1ec7ee86d9cb9b768b048398060ad3d52d01771df85eaecda3</citedby><cites>FETCH-LOGICAL-c545t-be00d5c6515e24c1ec7ee86d9cb9b768b048398060ad3d52d01771df85eaecda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa032423$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa032423$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15841955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15152059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bristow, Michael R</creatorcontrib><creatorcontrib>Saxon, Leslie A</creatorcontrib><creatorcontrib>Boehmer, John</creatorcontrib><creatorcontrib>Krueger, Steven</creatorcontrib><creatorcontrib>Kass, David A</creatorcontrib><creatorcontrib>De Marco, Teresa</creatorcontrib><creatorcontrib>Carson, Peter</creatorcontrib><creatorcontrib>DiCarlo, Lorenzo</creatorcontrib><creatorcontrib>DeMets, David</creatorcontrib><creatorcontrib>White, Bill G</creatorcontrib><creatorcontrib>DeVries, Dale W</creatorcontrib><creatorcontrib>Feldman, Arthur M</creatorcontrib><creatorcontrib>Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators</creatorcontrib><title>Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Some patients with chronic heart failure have intraventricular conduction delays, which cause asynchronous contraction of the left ventricle. This large clinical trial confirmed that biventricular pacing to restore synchronous contraction has significant benefits in such patients. The addition of an implantable defibrillator further reduces mortality.
Resynchronization therapy may have clinical benefit, especially when combined with an implantable defibrillator.
Intraventricular conduction delays are associated with dyssynchronous left ventricular contraction caused by regional delays in the electrical activation of the chamber.
1
,
2
This phenomenon, which occurs in 15 to 30 percent
3
–
5
of patients with heart failure due to dilated cardiomyopathy, reduces systolic function and increases systolic volume.
6
–
8
In patients with primary or secondary dilated cardiomyopathies characterized by intraventricular conduction delays, biventricular stimulation synchronizes the activation of the intraventricular septum and left ventricular free wall and thus improves left ventricular systolic function.
6
–
8
In short-term studies, cardiac-resynchronization therapy in the form of biventricular stimulation improved symptoms,
9
–
12
improved the . . .</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Aged</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Chronic Disease</subject><subject>Combined Modality Therapy</subject><subject>Defibrillators, Implantable</subject><subject>Diuretics - therapeutic use</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - therapy</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pacemaker, Artificial</subject><subject>Risk</subject><subject>Spironolactone - therapeutic use</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - therapy</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0U1v1DAQBmALUdGlcOOMLAScGvBnEh-rpaVFBSRUztHEnmi9SpxgJ6Dl1-N2V6KqOpe5PHpnNEPIK84-cKbLj9_Ov3wdgUmhhHxCVlxLWSjFyqdkxZioC1UZeUyep7Rlubgyz8gx11wLps2KTGuIzoMtfmDaBbuJY_B_YfZjoDcbjDDt6B8_b-gY7_q4zBQCvRqmHsIMbY_0E3a-jb7vYc7IB3rmfkOw6Oj6Ls3SS4Q40wvw_RLxBTnqoE_48tBPyM-L85v1ZXH9_fPV-uy6sFrpuWiRMadtmRdFoSxHWyHWpTO2NW1V1i1TtTQ1Kxk46bRwjFcVd12tEdA6kCfk_T53iuOvBdPcDD5ZzGsGHJfUVNyoSpY8wzcP4HZcYsi7NUJIo5gROqPTPbJxTCli10zRDxB3DWfN7Rua-2_I_PUhc2kHdP_x4e4ZvDsASBb6LuaL-XTP1YobfTv37d4NQ2oCbofH5_0D_DOb5w</recordid><startdate>20040520</startdate><enddate>20040520</enddate><creator>Bristow, Michael R</creator><creator>Saxon, Leslie A</creator><creator>Boehmer, John</creator><creator>Krueger, Steven</creator><creator>Kass, David A</creator><creator>De Marco, Teresa</creator><creator>Carson, Peter</creator><creator>DiCarlo, Lorenzo</creator><creator>DeMets, David</creator><creator>White, Bill G</creator><creator>DeVries, Dale W</creator><creator>Feldman, Arthur M</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040520</creationdate><title>Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure</title><author>Bristow, Michael R ; Saxon, Leslie A ; Boehmer, John ; Krueger, Steven ; Kass, David A ; De Marco, Teresa ; Carson, Peter ; DiCarlo, Lorenzo ; DeMets, David ; White, Bill G ; DeVries, Dale W ; Feldman, Arthur M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-be00d5c6515e24c1ec7ee86d9cb9b768b048398060ad3d52d01771df85eaecda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Aged</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Chronic Disease</topic><topic>Combined Modality Therapy</topic><topic>Defibrillators, Implantable</topic><topic>Diuretics - therapeutic use</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - therapy</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pacemaker, Artificial</topic><topic>Risk</topic><topic>Spironolactone - therapeutic use</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bristow, Michael R</creatorcontrib><creatorcontrib>Saxon, Leslie A</creatorcontrib><creatorcontrib>Boehmer, John</creatorcontrib><creatorcontrib>Krueger, Steven</creatorcontrib><creatorcontrib>Kass, David A</creatorcontrib><creatorcontrib>De Marco, Teresa</creatorcontrib><creatorcontrib>Carson, Peter</creatorcontrib><creatorcontrib>DiCarlo, Lorenzo</creatorcontrib><creatorcontrib>DeMets, David</creatorcontrib><creatorcontrib>White, Bill G</creatorcontrib><creatorcontrib>DeVries, Dale W</creatorcontrib><creatorcontrib>Feldman, Arthur M</creatorcontrib><creatorcontrib>Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bristow, Michael R</au><au>Saxon, Leslie A</au><au>Boehmer, John</au><au>Krueger, Steven</au><au>Kass, David A</au><au>De Marco, Teresa</au><au>Carson, Peter</au><au>DiCarlo, Lorenzo</au><au>DeMets, David</au><au>White, Bill G</au><au>DeVries, Dale W</au><au>Feldman, Arthur M</au><aucorp>Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2004-05-20</date><risdate>2004</risdate><volume>350</volume><issue>21</issue><spage>2140</spage><epage>2150</epage><pages>2140-2150</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Some patients with chronic heart failure have intraventricular conduction delays, which cause asynchronous contraction of the left ventricle. This large clinical trial confirmed that biventricular pacing to restore synchronous contraction has significant benefits in such patients. The addition of an implantable defibrillator further reduces mortality.
Resynchronization therapy may have clinical benefit, especially when combined with an implantable defibrillator.
Intraventricular conduction delays are associated with dyssynchronous left ventricular contraction caused by regional delays in the electrical activation of the chamber.
1
,
2
This phenomenon, which occurs in 15 to 30 percent
3
–
5
of patients with heart failure due to dilated cardiomyopathy, reduces systolic function and increases systolic volume.
6
–
8
In patients with primary or secondary dilated cardiomyopathies characterized by intraventricular conduction delays, biventricular stimulation synchronizes the activation of the intraventricular septum and left ventricular free wall and thus improves left ventricular systolic function.
6
–
8
In short-term studies, cardiac-resynchronization therapy in the form of biventricular stimulation improved symptoms,
9
–
12
improved the . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>15152059</pmid><doi>10.1056/NEJMoa032423</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2004-05, Vol.350 (21), p.2140-2150 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71947361 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adrenergic beta-Antagonists - therapeutic use Aged Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences Cardiology. Vascular system Chronic Disease Combined Modality Therapy Defibrillators, Implantable Diuretics - therapeutic use Female General aspects Heart Heart failure Heart Failure - complications Heart Failure - drug therapy Heart Failure - mortality Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hospitalization Humans Male Medical sciences Pacemaker, Artificial Risk Spironolactone - therapeutic use Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - therapy |
| title | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure |
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