Bladder carcinoma in a transplant recipient: Evidence to implicate the BK human polyomavirus as a causal transforming agent
The BK polyomavirus (BKV) infects most of the human population, but clinically relevant infections are mostly limited to individuals who are immunosuppressed. In transplant recipients, BKV has been associated with ureteral stenosis, interstitial nephritis, and hemorrhagic cystitis. The role of BKV i...
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| Veröffentlicht in: | Transplantation 2002-06, Vol.73 (12), p.1933-1936 |
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| container_end_page | 1936 |
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| container_issue | 12 |
| container_start_page | 1933 |
| container_title | Transplantation |
| container_volume | 73 |
| creator | GEETHA, Duvuru TONG, Betty C RACUSEN, Lorraine MARKOWITZ, Jay S WESTRA, William H |
| description | The BK polyomavirus (BKV) infects most of the human population, but clinically relevant infections are mostly limited to individuals who are immunosuppressed. In transplant recipients, BKV has been associated with ureteral stenosis, interstitial nephritis, and hemorrhagic cystitis. The role of BKV in the development of human tumors is intriguing but uncertain. BKV has been identified in various tumor types including urothelial carcinoma, but the ubiquitous presence of BKV as a latent infection has confounded efforts to validate any causal role in cancer development. We report the case of a simultaneous pancreas and kidney transplant recipient who developed BKV interstitial nephritis and carcinoma of the bladder with widespread metastases. High level expression of BKV large T antigen in the primary and metastatic carcinoma, but not in the nonneoplastic urothelium, implicates BKV as an etiologic agent in the development of this tumor. |
| doi_str_mv | 10.1097/00007890-200206270-00015 |
| format | Article |
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In transplant recipients, BKV has been associated with ureteral stenosis, interstitial nephritis, and hemorrhagic cystitis. The role of BKV in the development of human tumors is intriguing but uncertain. BKV has been identified in various tumor types including urothelial carcinoma, but the ubiquitous presence of BKV as a latent infection has confounded efforts to validate any causal role in cancer development. We report the case of a simultaneous pancreas and kidney transplant recipient who developed BKV interstitial nephritis and carcinoma of the bladder with widespread metastases. High level expression of BKV large T antigen in the primary and metastatic carcinoma, but not in the nonneoplastic urothelium, implicates BKV as an etiologic agent in the development of this tumor.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-200206270-00015</identifier><identifier>PMID: 12131691</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Biological and medical sciences ; BK Virus ; DNA, Viral - analysis ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Kidney Transplantation - adverse effects ; Male ; Middle Aged ; Pancreas Transplantation - adverse effects ; Polyomavirus Infections - complications ; Tissue, organ and graft immunology ; Tumor Virus Infections - complications ; Urinary Bladder Neoplasms - etiology ; Urinary Bladder Neoplasms - pathology</subject><ispartof>Transplantation, 2002-06, Vol.73 (12), p.1933-1936</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-9ca77b17442147a1fbdab9f6b884dec7876dcffba60476ed7434a4df3c6c04c03</citedby><cites>FETCH-LOGICAL-c517t-9ca77b17442147a1fbdab9f6b884dec7876dcffba60476ed7434a4df3c6c04c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13800479$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12131691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GEETHA, Duvuru</creatorcontrib><creatorcontrib>TONG, Betty C</creatorcontrib><creatorcontrib>RACUSEN, Lorraine</creatorcontrib><creatorcontrib>MARKOWITZ, Jay S</creatorcontrib><creatorcontrib>WESTRA, William H</creatorcontrib><title>Bladder carcinoma in a transplant recipient: Evidence to implicate the BK human polyomavirus as a causal transforming agent</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>The BK polyomavirus (BKV) infects most of the human population, but clinically relevant infections are mostly limited to individuals who are immunosuppressed. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreas Transplantation - adverse effects</subject><subject>Polyomavirus Infections - complications</subject><subject>Tissue, organ and graft immunology</subject><subject>Tumor Virus Infections - complications</subject><subject>Urinary Bladder Neoplasms - etiology</subject><subject>Urinary Bladder Neoplasms - pathology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQRi1ERW8LfwF5A7vAOHY8DjtatRRRqRtYRxM_WqO8sJNKVf98DfdCl1iWLFtnPmvmMMYFfBDQ4kcoC00LVQ1Qg64RqvIimhdsJxqpKg0GXrIdgBKVkBKP2UnOPwvSSMRX7FjUQgrdih17PBvIOZ-4pWTjNI_E48SJr4mmvAw0rTx5G5fop_UTv7iPzk_W83XmcVyGaGktlzvPz77xu22kiS_z8FBS7mPaMqeyS_KWadgnhjmNcbrldFvyXrOjQEP2bw7nKftxefH9_Kq6vvny9fzzdWUbgWvVWkLsBSpVC4UkQu-ob4PujVHOWzSonQ2hJw0KtXeopCLlgrTagrIgT9n7fe6S5l-bz2s3xmz9ULrz85Y7FK3CWsv_gsKYBkGpApo9aNOcc_KhW1IcKT10Arrfhrq_hrp_hro_hkrp28MfWz9691x4UFKAdweAsqUhlLHZmJ85aYpWbOUTWVuadA</recordid><startdate>20020627</startdate><enddate>20020627</enddate><creator>GEETHA, Duvuru</creator><creator>TONG, Betty C</creator><creator>RACUSEN, Lorraine</creator><creator>MARKOWITZ, Jay S</creator><creator>WESTRA, William H</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020627</creationdate><title>Bladder carcinoma in a transplant recipient: Evidence to implicate the BK human polyomavirus as a causal transforming agent</title><author>GEETHA, Duvuru ; TONG, Betty C ; RACUSEN, Lorraine ; MARKOWITZ, Jay S ; WESTRA, William H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-9ca77b17442147a1fbdab9f6b884dec7876dcffba60476ed7434a4df3c6c04c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>BK Virus</topic><topic>DNA, Viral - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreas Transplantation - adverse effects</topic><topic>Polyomavirus Infections - complications</topic><topic>Tissue, organ and graft immunology</topic><topic>Tumor Virus Infections - complications</topic><topic>Urinary Bladder Neoplasms - etiology</topic><topic>Urinary Bladder Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GEETHA, Duvuru</creatorcontrib><creatorcontrib>TONG, Betty C</creatorcontrib><creatorcontrib>RACUSEN, Lorraine</creatorcontrib><creatorcontrib>MARKOWITZ, Jay S</creatorcontrib><creatorcontrib>WESTRA, William H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GEETHA, Duvuru</au><au>TONG, Betty C</au><au>RACUSEN, Lorraine</au><au>MARKOWITZ, Jay S</au><au>WESTRA, William H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bladder carcinoma in a transplant recipient: Evidence to implicate the BK human polyomavirus as a causal transforming agent</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2002-06-27</date><risdate>2002</risdate><volume>73</volume><issue>12</issue><spage>1933</spage><epage>1936</epage><pages>1933-1936</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The BK polyomavirus (BKV) infects most of the human population, but clinically relevant infections are mostly limited to individuals who are immunosuppressed. 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| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 2002-06, Vol.73 (12), p.1933-1936 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences BK Virus DNA, Viral - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Kidney Transplantation - adverse effects Male Middle Aged Pancreas Transplantation - adverse effects Polyomavirus Infections - complications Tissue, organ and graft immunology Tumor Virus Infections - complications Urinary Bladder Neoplasms - etiology Urinary Bladder Neoplasms - pathology |
| title | Bladder carcinoma in a transplant recipient: Evidence to implicate the BK human polyomavirus as a causal transforming agent |
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