A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density
Previously, we identified two significant quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected for bone size) on chromosomes (Chrs) 11 and 13 by interval mapping in two mouse strains, SAMP2 and SAMP6. The latter strain is an established murine model of senile os...
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| Veröffentlicht in: | Mammalian genome 2002-07, Vol.13 (7), p.335-340 |
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| creator | Shimizu, Motoyuki Higuchi, Keiichi Kasai, Soichiro Tsuboyama, Tadao Matsushita, Mutsumi Matsumura, Takuro Okudaira, Shuzo Mori, Masayuki Koizumi, Akio Nakamura, Takashi Hosokawa, Masanori |
| description | Previously, we identified two significant quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected for bone size) on chromosomes (Chrs) 11 and 13 by interval mapping in two mouse strains, SAMP2 and SAMP6. The latter strain is an established murine model of senile osteoporosis and exhibits a significantly lower peak relative bone mass than SAMP2 mice. We recently designated the Chr 13 locus as Pbd2 (Peak bone density 2) and constructed a congenic strain, P6.P2-Pbd2(b), which carried a single genomic interval from the Chr 13 of SAMP2 on a SAMP6-derived osteoporotic background. In this study, we have constructed a congenic strain, P2.P6-Pbd2(a), carrying a SAMP6-derived susceptible interval on a SAMP2-derived resistance background. This congenic strain had a lower bone density than the background strain, SAMP2, based on three measurement methods, each utilizing a different principle for evaluating bone density: MD, DXA, and pQCT. Next, a candidate gene approach was used to find polymorphisms of Bmp6 (bone morphogenetic protein 6). The CAG trinucleotide repeat numbers in exon 1 of this gene differ among SAM strains. We found an association of CAG repeat length with relative peak bone mass in mice. |
| doi_str_mv | 10.1007/s00335-001-2129-4 |
| format | Article |
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The latter strain is an established murine model of senile osteoporosis and exhibits a significantly lower peak relative bone mass than SAMP2 mice. We recently designated the Chr 13 locus as Pbd2 (Peak bone density 2) and constructed a congenic strain, P6.P2-Pbd2(b), which carried a single genomic interval from the Chr 13 of SAMP2 on a SAMP6-derived osteoporotic background. In this study, we have constructed a congenic strain, P2.P6-Pbd2(a), carrying a SAMP6-derived susceptible interval on a SAMP2-derived resistance background. This congenic strain had a lower bone density than the background strain, SAMP2, based on three measurement methods, each utilizing a different principle for evaluating bone density: MD, DXA, and pQCT. Next, a candidate gene approach was used to find polymorphisms of Bmp6 (bone morphogenetic protein 6). The CAG trinucleotide repeat numbers in exon 1 of this gene differ among SAM strains. We found an association of CAG repeat length with relative peak bone mass in mice.</description><identifier>ISSN: 0938-8990</identifier><identifier>EISSN: 1432-1777</identifier><identifier>DOI: 10.1007/s00335-001-2129-4</identifier><identifier>PMID: 12140680</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Base Sequence ; Bone Density - genetics ; Chromosome Mapping ; Chromosomes, Mammalian - genetics ; Femur - anatomy & histology ; Mice ; Mice, Congenic ; Mice, Inbred Strains ; Molecular Sequence Data ; Organ Size ; Phenotype ; Polymorphism, Genetic - genetics ; Quantitative Trait Loci - genetics ; Trinucleotide Repeats - genetics</subject><ispartof>Mammalian genome, 2002-07, Vol.13 (7), p.335-340</ispartof><rights>Springer-Verlag New York Inc. 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-fd9edec389d502737a49a344c807c0f11c39eb21d91fdf28fcbbc61fff81dd853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12140680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Motoyuki</creatorcontrib><creatorcontrib>Higuchi, Keiichi</creatorcontrib><creatorcontrib>Kasai, Soichiro</creatorcontrib><creatorcontrib>Tsuboyama, Tadao</creatorcontrib><creatorcontrib>Matsushita, Mutsumi</creatorcontrib><creatorcontrib>Matsumura, Takuro</creatorcontrib><creatorcontrib>Okudaira, Shuzo</creatorcontrib><creatorcontrib>Mori, Masayuki</creatorcontrib><creatorcontrib>Koizumi, Akio</creatorcontrib><creatorcontrib>Nakamura, Takashi</creatorcontrib><creatorcontrib>Hosokawa, Masanori</creatorcontrib><title>A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density</title><title>Mammalian genome</title><addtitle>Mamm Genome</addtitle><description>Previously, we identified two significant quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected for bone size) on chromosomes (Chrs) 11 and 13 by interval mapping in two mouse strains, SAMP2 and SAMP6. The latter strain is an established murine model of senile osteoporosis and exhibits a significantly lower peak relative bone mass than SAMP2 mice. We recently designated the Chr 13 locus as Pbd2 (Peak bone density 2) and constructed a congenic strain, P6.P2-Pbd2(b), which carried a single genomic interval from the Chr 13 of SAMP2 on a SAMP6-derived osteoporotic background. In this study, we have constructed a congenic strain, P2.P6-Pbd2(a), carrying a SAMP6-derived susceptible interval on a SAMP2-derived resistance background. This congenic strain had a lower bone density than the background strain, SAMP2, based on three measurement methods, each utilizing a different principle for evaluating bone density: MD, DXA, and pQCT. Next, a candidate gene approach was used to find polymorphisms of Bmp6 (bone morphogenetic protein 6). The CAG trinucleotide repeat numbers in exon 1 of this gene differ among SAM strains. We found an association of CAG repeat length with relative peak bone mass in mice.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Bone Density - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Femur - anatomy & histology</subject><subject>Mice</subject><subject>Mice, Congenic</subject><subject>Mice, Inbred Strains</subject><subject>Molecular Sequence Data</subject><subject>Organ Size</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Quantitative Trait Loci - genetics</subject><subject>Trinucleotide Repeats - genetics</subject><issn>0938-8990</issn><issn>1432-1777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1LxDAQhoMo7rr6A7xIQPBWzSRpkxyXxS9Y8KJeQ5uP3S5tszbtwX9vyi4IXrzMwMwzw7zzInQN5B4IEQ-REMbyjBDIKFCV8RM0B85oBkKIUzQnislMKkVm6CLGXeJEAeIczYACJ4Ukc_S5xCZ0G9fVBrdhjA6XncUmhdqWg8Opk0oDHrYOr7Z9aEMMrcPAcBPMGHHvNmNTDnW3wVVIqHVdrIfvS3Tmyya6q2NeoI-nx_fVS7Z-e35dLdeZYXkxZN4qZ51hUtmcUMFEyVXJODeSCEM8gGHKVRSsAm89ld5UlSnAey_BWpmzBbo77N334Wt0cdBtHY1rmrJzSY0WoLgAyv8FQeaKS6AJvP0D7sLYd0mEBkJBMJrziYIDZfoQY--83vd1W_bfCdKTN_rgjU4_15M3ejrh5rh5rFpnfyeOZrAfGoGI_A</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Shimizu, Motoyuki</creator><creator>Higuchi, Keiichi</creator><creator>Kasai, Soichiro</creator><creator>Tsuboyama, Tadao</creator><creator>Matsushita, Mutsumi</creator><creator>Matsumura, Takuro</creator><creator>Okudaira, Shuzo</creator><creator>Mori, Masayuki</creator><creator>Koizumi, Akio</creator><creator>Nakamura, Takashi</creator><creator>Hosokawa, Masanori</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density</title><author>Shimizu, Motoyuki ; Higuchi, Keiichi ; Kasai, Soichiro ; Tsuboyama, Tadao ; Matsushita, Mutsumi ; Matsumura, Takuro ; Okudaira, Shuzo ; Mori, Masayuki ; Koizumi, Akio ; Nakamura, Takashi ; Hosokawa, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-fd9edec389d502737a49a344c807c0f11c39eb21d91fdf28fcbbc61fff81dd853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Bone Density - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Mammalian - genetics</topic><topic>Femur - anatomy & histology</topic><topic>Mice</topic><topic>Mice, Congenic</topic><topic>Mice, Inbred Strains</topic><topic>Molecular Sequence Data</topic><topic>Organ Size</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Quantitative Trait Loci - genetics</topic><topic>Trinucleotide Repeats - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Motoyuki</creatorcontrib><creatorcontrib>Higuchi, Keiichi</creatorcontrib><creatorcontrib>Kasai, Soichiro</creatorcontrib><creatorcontrib>Tsuboyama, Tadao</creatorcontrib><creatorcontrib>Matsushita, Mutsumi</creatorcontrib><creatorcontrib>Matsumura, Takuro</creatorcontrib><creatorcontrib>Okudaira, Shuzo</creatorcontrib><creatorcontrib>Mori, Masayuki</creatorcontrib><creatorcontrib>Koizumi, Akio</creatorcontrib><creatorcontrib>Nakamura, Takashi</creatorcontrib><creatorcontrib>Hosokawa, Masanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mammalian genome</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Motoyuki</au><au>Higuchi, Keiichi</au><au>Kasai, Soichiro</au><au>Tsuboyama, Tadao</au><au>Matsushita, Mutsumi</au><au>Matsumura, Takuro</au><au>Okudaira, Shuzo</au><au>Mori, Masayuki</au><au>Koizumi, Akio</au><au>Nakamura, Takashi</au><au>Hosokawa, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density</atitle><jtitle>Mammalian genome</jtitle><addtitle>Mamm Genome</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>13</volume><issue>7</issue><spage>335</spage><epage>340</epage><pages>335-340</pages><issn>0938-8990</issn><eissn>1432-1777</eissn><abstract>Previously, we identified two significant quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected for bone size) on chromosomes (Chrs) 11 and 13 by interval mapping in two mouse strains, SAMP2 and SAMP6. The latter strain is an established murine model of senile osteoporosis and exhibits a significantly lower peak relative bone mass than SAMP2 mice. We recently designated the Chr 13 locus as Pbd2 (Peak bone density 2) and constructed a congenic strain, P6.P2-Pbd2(b), which carried a single genomic interval from the Chr 13 of SAMP2 on a SAMP6-derived osteoporotic background. In this study, we have constructed a congenic strain, P2.P6-Pbd2(a), carrying a SAMP6-derived susceptible interval on a SAMP2-derived resistance background. This congenic strain had a lower bone density than the background strain, SAMP2, based on three measurement methods, each utilizing a different principle for evaluating bone density: MD, DXA, and pQCT. Next, a candidate gene approach was used to find polymorphisms of Bmp6 (bone morphogenetic protein 6). The CAG trinucleotide repeat numbers in exon 1 of this gene differ among SAM strains. We found an association of CAG repeat length with relative peak bone mass in mice.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12140680</pmid><doi>10.1007/s00335-001-2129-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Base Sequence Bone Density - genetics Chromosome Mapping Chromosomes, Mammalian - genetics Femur - anatomy & histology Mice Mice, Congenic Mice, Inbred Strains Molecular Sequence Data Organ Size Phenotype Polymorphism, Genetic - genetics Quantitative Trait Loci - genetics Trinucleotide Repeats - genetics |
| title | A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density |
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