West Nile virus infection in reindeer (Rangifer tarandus)
West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known ca...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 2004-05, Vol.16 (3), p.219-222 |
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| container_title | Journal of veterinary diagnostic investigation |
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| creator | Palmer, Mitchell V Stoffregen, William C Rogers, Douglas G Hamir, Amir N Richt, Juergen A Pedersen, Douglas D Waters, W. Ray |
| description | West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99). |
| doi_str_mv | 10.1177/104063870401600307 |
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Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).</description><identifier>ISSN: 1943-4936</identifier><identifier>ISSN: 1040-6387</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/104063870401600307</identifier><identifier>PMID: 15152836</identifier><language>eng</language><publisher>Los Angeles, CA: J Vet Diagn Invest</publisher><subject>Animals ; Antibodies, Viral - blood ; Antigens, Viral - metabolism ; Brain - pathology ; Brain - virology ; immunohistochemistry ; Iowa ; Male ; Nebraska ; neurons ; Neurons - pathology ; Neurons - virology ; Neutralization Tests - veterinary ; Rangifer tarandus ; Reindeer - virology ; Reverse Transcriptase Polymerase Chain Reaction - veterinary ; RNA, Viral - chemistry ; RNA, Viral - genetics ; signs and symptoms (animals and humans) ; Spinal Cord - pathology ; Spinal Cord - virology ; viral antigens ; viral diseases of animals and humans ; viral encephalitis ; West Nile Fever - blood ; West Nile Fever - pathology ; West Nile Fever - veterinary ; West Nile Fever - virology ; West Nile virus ; West Nile virus - genetics ; West Nile virus - isolation & purification</subject><ispartof>Journal of veterinary diagnostic investigation, 2004-05, Vol.16 (3), p.219-222</ispartof><rights>2004 American Association of Veterinary Laboratory Diagnosticians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c20e7ca2379a30e2d3b89a7cd1d12b66ba8f8682f8687330e2f2c5c0a490185d3</citedby><cites>FETCH-LOGICAL-c438t-c20e7ca2379a30e2d3b89a7cd1d12b66ba8f8682f8687330e2f2c5c0a490185d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/104063870401600307$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/104063870401600307$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15152836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palmer, Mitchell V</creatorcontrib><creatorcontrib>Stoffregen, William C</creatorcontrib><creatorcontrib>Rogers, Douglas G</creatorcontrib><creatorcontrib>Hamir, Amir N</creatorcontrib><creatorcontrib>Richt, Juergen A</creatorcontrib><creatorcontrib>Pedersen, Douglas D</creatorcontrib><creatorcontrib>Waters, W. Ray</creatorcontrib><title>West Nile virus infection in reindeer (Rangifer tarandus)</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).</description><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens, Viral - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - virology</subject><subject>immunohistochemistry</subject><subject>Iowa</subject><subject>Male</subject><subject>Nebraska</subject><subject>neurons</subject><subject>Neurons - pathology</subject><subject>Neurons - virology</subject><subject>Neutralization Tests - veterinary</subject><subject>Rangifer tarandus</subject><subject>Reindeer - virology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - veterinary</subject><subject>RNA, Viral - chemistry</subject><subject>RNA, Viral - genetics</subject><subject>signs and symptoms (animals and humans)</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord - virology</subject><subject>viral antigens</subject><subject>viral diseases of animals and humans</subject><subject>viral encephalitis</subject><subject>West Nile Fever - blood</subject><subject>West Nile Fever - pathology</subject><subject>West Nile Fever - veterinary</subject><subject>West Nile Fever - virology</subject><subject>West Nile virus</subject><subject>West Nile virus - genetics</subject><subject>West Nile virus - isolation & purification</subject><issn>1943-4936</issn><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotlZfwIXOSnRRm5vMJJmlFP-gKKjFZUiTTJsynanJTMW3N2UKCoKb3LP47sk9B6FTwNcAnI8Ap5hRweMAhjHFfA_1IU_pMM0p2_-le-gohCXGGck4HKIeZJARQVkf5e82NMmTK22ycb4NiasKqxtXV1El3rrKWOuTyxdVzV0RVaO8qkwbro7RQaHKYE92c4Cmd7dv44fh5Pn-cXwzGeqUimaoCbZcK0J5rii2xNCZyBXXBgyQGWMzJQrBBNk-nG6JguhMY5XmGERm6ABddL5rX3-08Vq5ckHbslSVrdsgeUzJMoAIkg7Uvg7B20KuvVsp_yUBy21h8m9hcels597OVtb8rOwaisCoA4KaW7msW1_FtP9b7g5euPni03krw0qVZfyAyOXGOGCSSgJ5BM87sFC1VHPvgpy-Egw0BqdYRKtvlbiHpw</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Palmer, Mitchell V</creator><creator>Stoffregen, William C</creator><creator>Rogers, Douglas G</creator><creator>Hamir, Amir N</creator><creator>Richt, Juergen A</creator><creator>Pedersen, Douglas D</creator><creator>Waters, W. Ray</creator><general>J Vet Diagn Invest</general><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>West Nile virus infection in reindeer (Rangifer tarandus)</title><author>Palmer, Mitchell V ; Stoffregen, William C ; Rogers, Douglas G ; Hamir, Amir N ; Richt, Juergen A ; Pedersen, Douglas D ; Waters, W. Ray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c20e7ca2379a30e2d3b89a7cd1d12b66ba8f8682f8687330e2f2c5c0a490185d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens, Viral - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - virology</topic><topic>immunohistochemistry</topic><topic>Iowa</topic><topic>Male</topic><topic>Nebraska</topic><topic>neurons</topic><topic>Neurons - pathology</topic><topic>Neurons - virology</topic><topic>Neutralization Tests - veterinary</topic><topic>Rangifer tarandus</topic><topic>Reindeer - virology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - veterinary</topic><topic>RNA, Viral - chemistry</topic><topic>RNA, Viral - genetics</topic><topic>signs and symptoms (animals and humans)</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord - virology</topic><topic>viral antigens</topic><topic>viral diseases of animals and humans</topic><topic>viral encephalitis</topic><topic>West Nile Fever - blood</topic><topic>West Nile Fever - pathology</topic><topic>West Nile Fever - veterinary</topic><topic>West Nile Fever - virology</topic><topic>West Nile virus</topic><topic>West Nile virus - genetics</topic><topic>West Nile virus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palmer, Mitchell V</creatorcontrib><creatorcontrib>Stoffregen, William C</creatorcontrib><creatorcontrib>Rogers, Douglas G</creatorcontrib><creatorcontrib>Hamir, Amir N</creatorcontrib><creatorcontrib>Richt, Juergen A</creatorcontrib><creatorcontrib>Pedersen, Douglas D</creatorcontrib><creatorcontrib>Waters, W. Ray</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palmer, Mitchell V</au><au>Stoffregen, William C</au><au>Rogers, Douglas G</au><au>Hamir, Amir N</au><au>Richt, Juergen A</au><au>Pedersen, Douglas D</au><au>Waters, W. Ray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>West Nile virus infection in reindeer (Rangifer tarandus)</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>16</volume><issue>3</issue><spage>219</spage><epage>222</epage><pages>219-222</pages><issn>1943-4936</issn><issn>1040-6387</issn><eissn>1943-4936</eissn><abstract>West Nile virus (WNV) infection in 4 reindeer (Rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. Immunohistochemistry revealed WNV antigen within neurons and among mononuclear cell infiltrates. These represent the first known cases of clinical WNV infection in Cervidae. Clinical signs and lesions were similar to those described in horses. Nucleotide sequence of a 768-bp region of the WNV E-glycoprotein gene revealed 1 nucleotide mutation, which resulted in a single amino acid substitution from a serine to a glycine (position 227 of E-glycoprotein) when compared with the prototype WNV-NY99 strain (isolated from Bronx zoo flamingo 382-99).</abstract><cop>Los Angeles, CA</cop><pub>J Vet Diagn Invest</pub><pmid>15152836</pmid><doi>10.1177/104063870401600307</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies, Viral - blood Antigens, Viral - metabolism Brain - pathology Brain - virology immunohistochemistry Iowa Male Nebraska neurons Neurons - pathology Neurons - virology Neutralization Tests - veterinary Rangifer tarandus Reindeer - virology Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA, Viral - chemistry RNA, Viral - genetics signs and symptoms (animals and humans) Spinal Cord - pathology Spinal Cord - virology viral antigens viral diseases of animals and humans viral encephalitis West Nile Fever - blood West Nile Fever - pathology West Nile Fever - veterinary West Nile Fever - virology West Nile virus West Nile virus - genetics West Nile virus - isolation & purification |
| title | West Nile virus infection in reindeer (Rangifer tarandus) |
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