CD40L association with protection from severe malaria
CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to al...
Gespeichert in:
| Veröffentlicht in: | Genes and immunity 2002-08, Vol.3 (5), p.286-291 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 291 |
|---|---|
| container_issue | 5 |
| container_start_page | 286 |
| container_title | Genes and immunity |
| container_volume | 3 |
| creator | Sabeti, P Usen, S Farhadian, S Jallow, M Doherty, T Newport, M Pinder, M Ward, R Kwiatkowski, D |
| description | CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to alter disease susceptibility remains to be explored. To identify polymorphisms in CD40L, we sequenced 2.3 kb of the 5′ flanking region and the first exon of the gene in DNA samples from 36 Gambian females and one chimpanzee. Diversity was lower than the average reported for other areas of the X chromosome, and only two polymorphisms were identified. The polymorphisms were genotyped in DNA samples from 957 Gambian individuals, cases and controls from a study of severe malaria. A significant reduction in risk for severe malaria (OR = 0.52, P = 0.002) was associated with males hemizygous for the CD40L−726C. Analysis by transmission disequilibrium test of 371 cases, for whom DNA from both parents was also available, confirmed the result was not due to stratification (P = 0.04). A similar but non-significant trend was found in females. This preliminary association of a common variant in CD40L with a malaria resistance phenotype encourages further genetic characterization of the role of CD40L in infectious disease. |
| doi_str_mv | 10.1038/sj.gene.6363877 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71946385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A200123903</galeid><sourcerecordid>A200123903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c584t-dd99b8aac778f4af2e4920923ed1acb925ec1c2b896f8e8acc849ce4a720cba13</originalsourceid><addsrcrecordid>eNqFktuL1DAUxoMo7rr67JNSVhB86GySprk8LuNtYUDw8hxO09MxQ9usSau7_70ZZ3QYcZE85HJ-35d84RDylNEFo5W-SJvFGkdcyEpWWql75JQJJctaKHp_u5ayFFqZE_IopQ2lTDJpHpITxpmgSqhTUi9fC7oqIKXgPEw-jMUPP30trmOY0P3adzEMRcLvGLEYoIfo4TF50EGf8Ml-PiNf3r75vHxfrj68u1perkpXazGVbWtMowGcUroT0HEUhlPDK2wZuMbwGh1zvNFGdho1OKeFcShAceoaYNUZebnzzc_5NmOa7OCTw76HEcOcrGJG5OD1f0GmhTZGqwy--AvchDmOOYTlUjBVGcp0ps7vpJjWsmaUH6zW0KP1YxemCG57r73k-a959qoytfgHlUeLg3dhxM7n8yPBqyNBZia8mdYwp2SvPn08Zi92rIshpYidvY5-gHhrGbXbBrFpY7cNYvcNkhXP98nmZsD2wO87IgN0B6RcGtcYD9Hv9ny2k4wwzRH_eP6u_wS-hs0Z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218865102</pqid></control><display><type>article</type><title>CD40L association with protection from severe malaria</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sabeti, P ; Usen, S ; Farhadian, S ; Jallow, M ; Doherty, T ; Newport, M ; Pinder, M ; Ward, R ; Kwiatkowski, D</creator><creatorcontrib>Sabeti, P ; Usen, S ; Farhadian, S ; Jallow, M ; Doherty, T ; Newport, M ; Pinder, M ; Ward, R ; Kwiatkowski, D</creatorcontrib><description>CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to alter disease susceptibility remains to be explored. To identify polymorphisms in CD40L, we sequenced 2.3 kb of the 5′ flanking region and the first exon of the gene in DNA samples from 36 Gambian females and one chimpanzee. Diversity was lower than the average reported for other areas of the X chromosome, and only two polymorphisms were identified. The polymorphisms were genotyped in DNA samples from 957 Gambian individuals, cases and controls from a study of severe malaria. A significant reduction in risk for severe malaria (OR = 0.52, P = 0.002) was associated with males hemizygous for the CD40L−726C. Analysis by transmission disequilibrium test of 371 cases, for whom DNA from both parents was also available, confirmed the result was not due to stratification (P = 0.04). A similar but non-significant trend was found in females. This preliminary association of a common variant in CD40L with a malaria resistance phenotype encourages further genetic characterization of the role of CD40L in infectious disease.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/sj.gene.6363877</identifier><identifier>PMID: 12140747</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Animals ; Antigen-presenting cells ; Antigens ; Base Sequence ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; CD40 antigen ; CD40 Ligand - genetics ; CD40L protein ; Cell activation ; Cell growth ; Cell proliferation ; Chromosomes, Human, X - genetics ; Class switching ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Female ; full-paper ; Gambia ; Gene Expression ; Gene Frequency ; Genes ; Genetic testing ; Genetic Variation ; Glycoproteins ; Haplotypes ; HIV ; Human Genetics ; Human immunodeficiency virus ; Humans ; Immunodeficiency ; Immunoglobulins ; Immunology ; Infections ; Infectious diseases ; Ligands ; Lymphocytes ; Lymphocytes B ; Malaria ; Malaria, Falciparum - genetics ; Malaria, Falciparum - immunology ; Malaria, Falciparum - prevention & control ; Male ; Molecular Sequence Data ; Monkeys & apes ; Pan troglodytes ; Phenotype ; Phenotypes ; Promoter Regions, Genetic ; X chromosomes</subject><ispartof>Genes and immunity, 2002-08, Vol.3 (5), p.286-291</ispartof><rights>Macmillan Publishers Limited 2002</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2002</rights><rights>Macmillan Publishers Limited 2002.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-dd99b8aac778f4af2e4920923ed1acb925ec1c2b896f8e8acc849ce4a720cba13</citedby><cites>FETCH-LOGICAL-c584t-dd99b8aac778f4af2e4920923ed1acb925ec1c2b896f8e8acc849ce4a720cba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.gene.6363877$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.gene.6363877$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12140747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabeti, P</creatorcontrib><creatorcontrib>Usen, S</creatorcontrib><creatorcontrib>Farhadian, S</creatorcontrib><creatorcontrib>Jallow, M</creatorcontrib><creatorcontrib>Doherty, T</creatorcontrib><creatorcontrib>Newport, M</creatorcontrib><creatorcontrib>Pinder, M</creatorcontrib><creatorcontrib>Ward, R</creatorcontrib><creatorcontrib>Kwiatkowski, D</creatorcontrib><title>CD40L association with protection from severe malaria</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to alter disease susceptibility remains to be explored. To identify polymorphisms in CD40L, we sequenced 2.3 kb of the 5′ flanking region and the first exon of the gene in DNA samples from 36 Gambian females and one chimpanzee. Diversity was lower than the average reported for other areas of the X chromosome, and only two polymorphisms were identified. The polymorphisms were genotyped in DNA samples from 957 Gambian individuals, cases and controls from a study of severe malaria. A significant reduction in risk for severe malaria (OR = 0.52, P = 0.002) was associated with males hemizygous for the CD40L−726C. Analysis by transmission disequilibrium test of 371 cases, for whom DNA from both parents was also available, confirmed the result was not due to stratification (P = 0.04). A similar but non-significant trend was found in females. This preliminary association of a common variant in CD40L with a malaria resistance phenotype encourages further genetic characterization of the role of CD40L in infectious disease.</description><subject>Alleles</subject><subject>Animals</subject><subject>Antigen-presenting cells</subject><subject>Antigens</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>CD40 antigen</subject><subject>CD40 Ligand - genetics</subject><subject>CD40L protein</subject><subject>Cell activation</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Chromosomes, Human, X - genetics</subject><subject>Class switching</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>full-paper</subject><subject>Gambia</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic testing</subject><subject>Genetic Variation</subject><subject>Glycoproteins</subject><subject>Haplotypes</subject><subject>HIV</subject><subject>Human Genetics</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Malaria</subject><subject>Malaria, Falciparum - genetics</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - prevention & control</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Monkeys & apes</subject><subject>Pan troglodytes</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Promoter Regions, Genetic</subject><subject>X chromosomes</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFktuL1DAUxoMo7rr67JNSVhB86GySprk8LuNtYUDw8hxO09MxQ9usSau7_70ZZ3QYcZE85HJ-35d84RDylNEFo5W-SJvFGkdcyEpWWql75JQJJctaKHp_u5ayFFqZE_IopQ2lTDJpHpITxpmgSqhTUi9fC7oqIKXgPEw-jMUPP30trmOY0P3adzEMRcLvGLEYoIfo4TF50EGf8Ml-PiNf3r75vHxfrj68u1perkpXazGVbWtMowGcUroT0HEUhlPDK2wZuMbwGh1zvNFGdho1OKeFcShAceoaYNUZebnzzc_5NmOa7OCTw76HEcOcrGJG5OD1f0GmhTZGqwy--AvchDmOOYTlUjBVGcp0ps7vpJjWsmaUH6zW0KP1YxemCG57r73k-a959qoytfgHlUeLg3dhxM7n8yPBqyNBZia8mdYwp2SvPn08Zi92rIshpYidvY5-gHhrGbXbBrFpY7cNYvcNkhXP98nmZsD2wO87IgN0B6RcGtcYD9Hv9ny2k4wwzRH_eP6u_wS-hs0Z</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Sabeti, P</creator><creator>Usen, S</creator><creator>Farhadian, S</creator><creator>Jallow, M</creator><creator>Doherty, T</creator><creator>Newport, M</creator><creator>Pinder, M</creator><creator>Ward, R</creator><creator>Kwiatkowski, D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>CD40L association with protection from severe malaria</title><author>Sabeti, P ; Usen, S ; Farhadian, S ; Jallow, M ; Doherty, T ; Newport, M ; Pinder, M ; Ward, R ; Kwiatkowski, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-dd99b8aac778f4af2e4920923ed1acb925ec1c2b896f8e8acc849ce4a720cba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Antigen-presenting cells</topic><topic>Antigens</topic><topic>Base Sequence</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>CD40 antigen</topic><topic>CD40 Ligand - genetics</topic><topic>CD40L protein</topic><topic>Cell activation</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Chromosomes, Human, X - genetics</topic><topic>Class switching</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>full-paper</topic><topic>Gambia</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic testing</topic><topic>Genetic Variation</topic><topic>Glycoproteins</topic><topic>Haplotypes</topic><topic>HIV</topic><topic>Human Genetics</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Malaria</topic><topic>Malaria, Falciparum - genetics</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Monkeys & apes</topic><topic>Pan troglodytes</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Promoter Regions, Genetic</topic><topic>X chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabeti, P</creatorcontrib><creatorcontrib>Usen, S</creatorcontrib><creatorcontrib>Farhadian, S</creatorcontrib><creatorcontrib>Jallow, M</creatorcontrib><creatorcontrib>Doherty, T</creatorcontrib><creatorcontrib>Newport, M</creatorcontrib><creatorcontrib>Pinder, M</creatorcontrib><creatorcontrib>Ward, R</creatorcontrib><creatorcontrib>Kwiatkowski, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabeti, P</au><au>Usen, S</au><au>Farhadian, S</au><au>Jallow, M</au><au>Doherty, T</au><au>Newport, M</au><au>Pinder, M</au><au>Ward, R</au><au>Kwiatkowski, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD40L association with protection from severe malaria</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2002-08</date><risdate>2002</risdate><volume>3</volume><issue>5</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection. Rare coding mutations in CD40L can lead to life-threatening immunodeficiency but the potential for common variants to alter disease susceptibility remains to be explored. To identify polymorphisms in CD40L, we sequenced 2.3 kb of the 5′ flanking region and the first exon of the gene in DNA samples from 36 Gambian females and one chimpanzee. Diversity was lower than the average reported for other areas of the X chromosome, and only two polymorphisms were identified. The polymorphisms were genotyped in DNA samples from 957 Gambian individuals, cases and controls from a study of severe malaria. A significant reduction in risk for severe malaria (OR = 0.52, P = 0.002) was associated with males hemizygous for the CD40L−726C. Analysis by transmission disequilibrium test of 371 cases, for whom DNA from both parents was also available, confirmed the result was not due to stratification (P = 0.04). A similar but non-significant trend was found in females. This preliminary association of a common variant in CD40L with a malaria resistance phenotype encourages further genetic characterization of the role of CD40L in infectious disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12140747</pmid><doi>10.1038/sj.gene.6363877</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-4879 |
| ispartof | Genes and immunity, 2002-08, Vol.3 (5), p.286-291 |
| issn | 1466-4879 1476-5470 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71946385 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Alleles Animals Antigen-presenting cells Antigens Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies CD40 antigen CD40 Ligand - genetics CD40L protein Cell activation Cell growth Cell proliferation Chromosomes, Human, X - genetics Class switching Deoxyribonucleic acid DNA DNA - genetics Female full-paper Gambia Gene Expression Gene Frequency Genes Genetic testing Genetic Variation Glycoproteins Haplotypes HIV Human Genetics Human immunodeficiency virus Humans Immunodeficiency Immunoglobulins Immunology Infections Infectious diseases Ligands Lymphocytes Lymphocytes B Malaria Malaria, Falciparum - genetics Malaria, Falciparum - immunology Malaria, Falciparum - prevention & control Male Molecular Sequence Data Monkeys & apes Pan troglodytes Phenotype Phenotypes Promoter Regions, Genetic X chromosomes |
| title | CD40L association with protection from severe malaria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T13%3A37%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD40L%20association%20with%20protection%20from%20severe%20malaria&rft.jtitle=Genes%20and%20immunity&rft.au=Sabeti,%20P&rft.date=2002-08&rft.volume=3&rft.issue=5&rft.spage=286&rft.epage=291&rft.pages=286-291&rft.issn=1466-4879&rft.eissn=1476-5470&rft_id=info:doi/10.1038/sj.gene.6363877&rft_dat=%3Cgale_proqu%3EA200123903%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218865102&rft_id=info:pmid/12140747&rft_galeid=A200123903&rfr_iscdi=true |