The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression
The myogenic regulatory family of basic helix-loop-helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte-specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upreg...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2002-07, Vol.524 (1), p.134-138 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 138 |
|---|---|
| container_issue | 1 |
| container_start_page | 134 |
| container_title | FEBS letters |
| container_volume | 524 |
| creator | Rogerson, Parker J Jamali, Mina Skerjanc, Ilona S |
| description | The myogenic regulatory family of basic helix-loop-helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte-specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upregulates MEF2C expression while MyoD does not [Ridgeway et al., J. Biol. Chem. 275 (2000) 41–46]. In order to identify the domain of myogenin responsible for activating MEF2C expression, a series of chimeras of MyoD and myogenin were generated. Only chimeras containing the C-terminal region of myogenin were able to activate MEF2C in aggregated P19 cells, suggesting that the C-terminus of myogenin is responsible for the regulation of specific target genes. |
| doi_str_mv | 10.1016/S0014-5793(02)03024-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71945012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579302030247</els_id><sourcerecordid>71945012</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4737-a78128b6589d44da156e6828e3c09b8c21af4ca8535cda4bd368c10826891dd73</originalsourceid><addsrcrecordid>eNqNkF1v0zAUhi0EYt3gJzD5CjFpAX_GzhWCrmVIm5BgXFuOfdp5SuLOTrb135O01biEK8vveXxe60HoHSUfKaHlp1-EUFFIVfEPhJ0RTpgo1As0o1rxgotSv0SzZ-QIHed8R8a7ptVrdEQZ5VJJOUM_b24Bz4seUhu6IeO4wu02rqEL3Tmuhx53scfX23hxjnub1tBnPGwSrIfG9iF2E3-9WLI5hqcxznnM3qBXK9tkeHs4T9Dv5eJmfllc_fj2ff7lqnBCcVVYpSnTdSl15YXwlsoSSs00cEeqWjtG7Uo4qyWXzltRe15qR4lmpa6o94qfoPf7vZsU7wfIvWlDdtA0toM4ZKNoJSShbATlHnQp5pxgZTYptDZtDSVmkml2Ms1kyhBmdjLNVHB6KBjqFvzfVwd7I3C5Bx5DA9v_22qWi69sN5kGhO3iqevzfhWMxh4CJJNdgM6BDwlcb3wM__jtHzrllho</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71945012</pqid></control><display><type>article</type><title>The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Rogerson, Parker J ; Jamali, Mina ; Skerjanc, Ilona S</creator><creatorcontrib>Rogerson, Parker J ; Jamali, Mina ; Skerjanc, Ilona S</creatorcontrib><description>The myogenic regulatory family of basic helix-loop-helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte-specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upregulates MEF2C expression while MyoD does not [Ridgeway et al., J. Biol. Chem. 275 (2000) 41–46]. In order to identify the domain of myogenin responsible for activating MEF2C expression, a series of chimeras of MyoD and myogenin were generated. Only chimeras containing the C-terminal region of myogenin were able to activate MEF2C in aggregated P19 cells, suggesting that the C-terminus of myogenin is responsible for the regulation of specific target genes.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(02)03024-7</identifier><identifier>PMID: 12135755</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; DMSO, dimethylsulfoxide ; DNA ; Embryonal carcinoma ; Fluorescent Antibody Technique ; MEF2 Transcription Factors ; Mice ; MyHC, myosin heavy chain ; Myocyte-specific enhancer binding factor 2C ; MyoD ; MyoD Protein - chemistry ; MyoD Protein - metabolism ; Myogenesis ; Myogenic Regulatory Factors - metabolism ; Myogenin ; Myogenin - chemistry ; Myogenin - metabolism ; P19 cell ; PGK, phosphoglycerate kinase ; Tumor Cells, Cultured ; Up-Regulation</subject><ispartof>FEBS letters, 2002-07, Vol.524 (1), p.134-138</ispartof><rights>2002 Federation of European Biochemical Societies</rights><rights>FEBS Letters 524 (2002) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4737-a78128b6589d44da156e6828e3c09b8c21af4ca8535cda4bd368c10826891dd73</citedby><cites>FETCH-LOGICAL-c4737-a78128b6589d44da156e6828e3c09b8c21af4ca8535cda4bd368c10826891dd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2802%2903024-7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579302030247$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12135755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rogerson, Parker J</creatorcontrib><creatorcontrib>Jamali, Mina</creatorcontrib><creatorcontrib>Skerjanc, Ilona S</creatorcontrib><title>The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The myogenic regulatory family of basic helix-loop-helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte-specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upregulates MEF2C expression while MyoD does not [Ridgeway et al., J. Biol. Chem. 275 (2000) 41–46]. In order to identify the domain of myogenin responsible for activating MEF2C expression, a series of chimeras of MyoD and myogenin were generated. Only chimeras containing the C-terminal region of myogenin were able to activate MEF2C in aggregated P19 cells, suggesting that the C-terminus of myogenin is responsible for the regulation of specific target genes.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>DMSO, dimethylsulfoxide</subject><subject>DNA</subject><subject>Embryonal carcinoma</subject><subject>Fluorescent Antibody Technique</subject><subject>MEF2 Transcription Factors</subject><subject>Mice</subject><subject>MyHC, myosin heavy chain</subject><subject>Myocyte-specific enhancer binding factor 2C</subject><subject>MyoD</subject><subject>MyoD Protein - chemistry</subject><subject>MyoD Protein - metabolism</subject><subject>Myogenesis</subject><subject>Myogenic Regulatory Factors - metabolism</subject><subject>Myogenin</subject><subject>Myogenin - chemistry</subject><subject>Myogenin - metabolism</subject><subject>P19 cell</subject><subject>PGK, phosphoglycerate kinase</subject><subject>Tumor Cells, Cultured</subject><subject>Up-Regulation</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi0EYt3gJzD5CjFpAX_GzhWCrmVIm5BgXFuOfdp5SuLOTrb135O01biEK8vveXxe60HoHSUfKaHlp1-EUFFIVfEPhJ0RTpgo1As0o1rxgotSv0SzZ-QIHed8R8a7ptVrdEQZ5VJJOUM_b24Bz4seUhu6IeO4wu02rqEL3Tmuhx53scfX23hxjnub1tBnPGwSrIfG9iF2E3-9WLI5hqcxznnM3qBXK9tkeHs4T9Dv5eJmfllc_fj2ff7lqnBCcVVYpSnTdSl15YXwlsoSSs00cEeqWjtG7Uo4qyWXzltRe15qR4lmpa6o94qfoPf7vZsU7wfIvWlDdtA0toM4ZKNoJSShbATlHnQp5pxgZTYptDZtDSVmkml2Ms1kyhBmdjLNVHB6KBjqFvzfVwd7I3C5Bx5DA9v_22qWi69sN5kGhO3iqevzfhWMxh4CJJNdgM6BDwlcb3wM__jtHzrllho</recordid><startdate>20020731</startdate><enddate>20020731</enddate><creator>Rogerson, Parker J</creator><creator>Jamali, Mina</creator><creator>Skerjanc, Ilona S</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020731</creationdate><title>The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression</title><author>Rogerson, Parker J ; Jamali, Mina ; Skerjanc, Ilona S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4737-a78128b6589d44da156e6828e3c09b8c21af4ca8535cda4bd368c10826891dd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>DMSO, dimethylsulfoxide</topic><topic>DNA</topic><topic>Embryonal carcinoma</topic><topic>Fluorescent Antibody Technique</topic><topic>MEF2 Transcription Factors</topic><topic>Mice</topic><topic>MyHC, myosin heavy chain</topic><topic>Myocyte-specific enhancer binding factor 2C</topic><topic>MyoD</topic><topic>MyoD Protein - chemistry</topic><topic>MyoD Protein - metabolism</topic><topic>Myogenesis</topic><topic>Myogenic Regulatory Factors - metabolism</topic><topic>Myogenin</topic><topic>Myogenin - chemistry</topic><topic>Myogenin - metabolism</topic><topic>P19 cell</topic><topic>PGK, phosphoglycerate kinase</topic><topic>Tumor Cells, Cultured</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogerson, Parker J</creatorcontrib><creatorcontrib>Jamali, Mina</creatorcontrib><creatorcontrib>Skerjanc, Ilona S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogerson, Parker J</au><au>Jamali, Mina</au><au>Skerjanc, Ilona S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2002-07-31</date><risdate>2002</risdate><volume>524</volume><issue>1</issue><spage>134</spage><epage>138</epage><pages>134-138</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The myogenic regulatory family of basic helix-loop-helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte-specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upregulates MEF2C expression while MyoD does not [Ridgeway et al., J. Biol. Chem. 275 (2000) 41–46]. In order to identify the domain of myogenin responsible for activating MEF2C expression, a series of chimeras of MyoD and myogenin were generated. Only chimeras containing the C-terminal region of myogenin were able to activate MEF2C in aggregated P19 cells, suggesting that the C-terminus of myogenin is responsible for the regulation of specific target genes.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>12135755</pmid><doi>10.1016/S0014-5793(02)03024-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2002-07, Vol.524 (1), p.134-138 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71945012 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Base Sequence DMSO, dimethylsulfoxide DNA Embryonal carcinoma Fluorescent Antibody Technique MEF2 Transcription Factors Mice MyHC, myosin heavy chain Myocyte-specific enhancer binding factor 2C MyoD MyoD Protein - chemistry MyoD Protein - metabolism Myogenesis Myogenic Regulatory Factors - metabolism Myogenin Myogenin - chemistry Myogenin - metabolism P19 cell PGK, phosphoglycerate kinase Tumor Cells, Cultured Up-Regulation |
| title | The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T01%3A35%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20C-terminus%20of%20myogenin,%20but%20not%20MyoD,%20targets%20upregulation%20of%20MEF2C%20expression&rft.jtitle=FEBS%20letters&rft.au=Rogerson,%20Parker%20J&rft.date=2002-07-31&rft.volume=524&rft.issue=1&rft.spage=134&rft.epage=138&rft.pages=134-138&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(02)03024-7&rft_dat=%3Cproquest_cross%3E71945012%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71945012&rft_id=info:pmid/12135755&rft_els_id=S0014579302030247&rfr_iscdi=true |