CE-108, a New Macrolide Tetraene Antibiotic
In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline....
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| Veröffentlicht in: | Journal of antibiotics 2004/03/25, Vol.57(3), pp.197-204 |
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| container_title | Journal of antibiotics |
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| creator | PÉREZ-ZÚÑIGA, FRANCISCO J. SECO, ELENA M. CUESTA, T. DEGENHARDT, FALKO ROHR, JÜRGEN VALLÍN, CARLOS IZNAGA, YANELIS PÉREZ, MARTA E. GONZÁLEZ, LEONORA MALPARTIDA, FRANCISCO |
| description | In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35% (CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. This paper deals with the characterization of the producer strain, fermentation, purification, structure determination and biological properties of the new macrolide tetraene CE-108. |
| doi_str_mv | 10.7164/antibiotics.57.197 |
| format | Article |
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Antibiot.</addtitle><description>In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35% (CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. This paper deals with the characterization of the producer strain, fermentation, purification, structure determination and biological properties of the new macrolide tetraene CE-108.</description><subject>Animals</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Cercopithecus aethiops</subject><subject>Fermentation</subject><subject>Macrolides - chemistry</subject><subject>Macrolides - isolation & purification</subject><subject>Macrolides - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Monosaccharides - chemistry</subject><subject>Monosaccharides - isolation & purification</subject><subject>Polyenes - pharmacology</subject><subject>Streptomyces</subject><subject>Vero Cells</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EouXjDzCgTCyQ4osdf4yo4ksUWMpsnZMzBKUNxKkQ_55UqQoby93y3HN3L2MnwCcalLzEZVf5qumqIk5yPQGrd9gYjIEUpLK7bMx5BqkxGR-xgxjfORdaaLPPRpBDnhmej9n59DoFbi4STJ7oK3nEom3qqqRkTl2LtKTkarvliO0FrCMdb_ohe7m5nk_v0tnz7f30apYWSvIu9RC4IWtLUXj0UimtTGbRGBFQ-CAkFQHQIC8lZt6GMmgko6T3_b0YrDhkZ4P3o20-VxQ7t6hiQXWNS2pW0WmwUma5-hcEw1WuDfRgNoD9dzG2FNxHWy2w_XbA3TpL9ydLl2vXZ9kPnW7sK7-g8ndkE14PPAzAe-zwlbYAtr2mpr9OsMqsvWIovX5LFW_YOlqKHztqjIY</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>PÉREZ-ZÚÑIGA, FRANCISCO J.</creator><creator>SECO, ELENA M.</creator><creator>CUESTA, T.</creator><creator>DEGENHARDT, FALKO</creator><creator>ROHR, JÜRGEN</creator><creator>VALLÍN, CARLOS</creator><creator>IZNAGA, YANELIS</creator><creator>PÉREZ, MARTA E.</creator><creator>GONZÁLEZ, LEONORA</creator><creator>MALPARTIDA, FRANCISCO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>CE-108, a New Macrolide Tetraene Antibiotic</title><author>PÉREZ-ZÚÑIGA, FRANCISCO J. ; SECO, ELENA M. ; CUESTA, T. ; DEGENHARDT, FALKO ; ROHR, JÜRGEN ; VALLÍN, CARLOS ; IZNAGA, YANELIS ; PÉREZ, MARTA E. ; GONZÁLEZ, LEONORA ; MALPARTIDA, FRANCISCO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c640t-b1f08e99d3cbab46676829a883fa3bf34ecf1a8a0d4a2b9fdf7ae864bb002af93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Cercopithecus aethiops</topic><topic>Fermentation</topic><topic>Macrolides - chemistry</topic><topic>Macrolides - isolation & purification</topic><topic>Macrolides - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Monosaccharides - chemistry</topic><topic>Monosaccharides - isolation & purification</topic><topic>Polyenes - pharmacology</topic><topic>Streptomyces</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PÉREZ-ZÚÑIGA, FRANCISCO J.</creatorcontrib><creatorcontrib>SECO, ELENA M.</creatorcontrib><creatorcontrib>CUESTA, T.</creatorcontrib><creatorcontrib>DEGENHARDT, FALKO</creatorcontrib><creatorcontrib>ROHR, JÜRGEN</creatorcontrib><creatorcontrib>VALLÍN, CARLOS</creatorcontrib><creatorcontrib>IZNAGA, YANELIS</creatorcontrib><creatorcontrib>PÉREZ, MARTA E.</creatorcontrib><creatorcontrib>GONZÁLEZ, LEONORA</creatorcontrib><creatorcontrib>MALPARTIDA, FRANCISCO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PÉREZ-ZÚÑIGA, FRANCISCO J.</au><au>SECO, ELENA M.</au><au>CUESTA, T.</au><au>DEGENHARDT, FALKO</au><au>ROHR, JÜRGEN</au><au>VALLÍN, CARLOS</au><au>IZNAGA, YANELIS</au><au>PÉREZ, MARTA E.</au><au>GONZÁLEZ, LEONORA</au><au>MALPARTIDA, FRANCISCO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CE-108, a New Macrolide Tetraene Antibiotic</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2004</date><risdate>2004</risdate><volume>57</volume><issue>3</issue><spage>197</spage><epage>204</epage><pages>197-204</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture broth of Streptomyces diastaticus 108. In addition, the strain also produces the previously described tetraene rimocidin (1) and also the aromatic polyketide oxytetracycline. Both tetraene compounds, structurally related, are produced in a ratio between 25 to 35% (CE-108 compared to rimocidin), although it can be inverted toward CE-108 production by changing the composition of the fermentation medium. 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| source | J-STAGE Free; MEDLINE |
| subjects | Animals Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Cercopithecus aethiops Fermentation Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Microbial Sensitivity Tests Monosaccharides - chemistry Monosaccharides - isolation & purification Polyenes - pharmacology Streptomyces Vero Cells |
| title | CE-108, a New Macrolide Tetraene Antibiotic |
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