Loss of Fhit Expression as a Potential Marker of Malignant Progression in Preinvasive Squamous Cervical Cancer

Objective. In a previous study using the same cases of squamous cervical neoplasia and microinvasive carcinoma (MICA) we found an association between FHIT gene deletion and infection with high-risk HPV (HR HPV). The purpose of this study was to evaluate Fhit protein expression by immunohistochemistr...

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Veröffentlicht in:	Gynecologic oncology 2002-08, Vol.86 (2), p.144-149
Hauptverfasser:	Butler, David, Collins, Claire, Mabruk, Mohamed, Leader, Mary B., Kay, Elaine W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases Adult Aged Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biopsy - methods Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology cervical cancer Cervical Intraepithelial Neoplasia - chemistry Cervical Intraepithelial Neoplasia - pathology Female Female genital diseases FHIT gene Fhit protein Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics HPV Humans Immunohistochemistry LOH Loss of Heterozygosity Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Proteins - analysis Neoplasm Proteins - genetics Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - diagnosis Polymerase Chain Reaction Tumor Virus Infections - diagnosis Tumors Uterine Cervical Neoplasms - chemistry Uterine Cervical Neoplasms - pathology
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