The effect of the 5‐HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients

Summary Aim : To conduct a placebo‐controlled functional brain imaging study to assess the effect of the 5‐hydroxytryptamine‐3 receptor antagonist, alosetron, on irritable bowel syndrome symptoms, regional brain activation by rectosigmoid distension and associated perceptual and emotional responses....

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2002-07, Vol.16 (7), p.1357-1366
Hauptverfasser:	Mayer, E. A., Berman, S., Derbyshire, S. W. G., Suyenobu, B., Chang, L., Fitzgerald, L., Mandelkern, M., Hamm, L., Vogt, B., Naliboff, B. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Brain - diagnostic imaging Brain - drug effects Brain - physiopathology Brain Chemistry Carbolines - pharmacology Carbolines - therapeutic use Cerebrovascular Circulation - drug effects Colonic Diseases, Functional - diagnostic imaging Colonic Diseases, Functional - drug therapy Colonic Diseases, Functional - physiopathology Digestive system Double-Blind Method Female Gastrointestinal Agents - pharmacology Gastrointestinal Agents - therapeutic use Humans Male Medical sciences Middle Aged Nociceptors - drug effects Nociceptors - physiopathology Pharmacology. Drug treatments Physical Stimulation - methods Receptors, Serotonin - analysis Receptors, Serotonin - drug effects Receptors, Serotonin, 5-HT3 Rectum - physiopathology Serotonin Antagonists - pharmacology Serotonin Antagonists - therapeutic use Tomography, Emission-Computed Treatment Outcome
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