LGI1, a Putative Tumor Metastasis Suppressor Gene, Controls in Vitro Invasiveness and Expression of Matrix Metalloproteinases in Glioma Cells through the ERK1/2 Pathway

Gliomas take a number of different genetic routes in the progression to glioblastoma multiforme, a highly invasive variant that is mostly unresponsive to current therapies. Gliomas express elevated levels of matrix metalloproteinases (MMPs), which have been implicated in the control of proliferation...

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Veröffentlicht in:	The Journal of biological chemistry 2004-05, Vol.279 (22), p.23151-23157
Hauptverfasser:	Kunapuli, Padmaja, Kasyapa, Chitta S., Hawthorn, Lesleyann, Cowell, John K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Glioma - genetics Glioma - pathology Humans Intracellular Signaling Peptides and Proteins Matrix Metalloproteinases - biosynthesis Matrix Metalloproteinases - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Neoplasm Invasiveness - genetics Proteins - genetics Signal Transduction - genetics
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