Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis
The aim of this study was to analyze histopathologically mucosal inflammation in patients with chronic rhinosinusitis. In addition, we assessed tissue eosinophilia in relation to the severity of inflammation and to the computer tomographic (CT) findings. Forty-eight pathological sinus mucosa specime...
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| Veröffentlicht in: | American journal of rhinology 2002-05, Vol.16 (3), p.131-134 |
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| creator | Szucs, Eva Ravandi, Saied Goossens, Anita Beel, Mieke Clement, Peter A R |
| description | The aim of this study was to analyze histopathologically mucosal inflammation in patients with chronic rhinosinusitis. In addition, we assessed tissue eosinophilia in relation to the severity of inflammation and to the computer tomographic (CT) findings.
Forty-eight pathological sinus mucosa specimens obtained during functional endoscopic sinus surgery were stained by hematoxvlin and eosin. Total inflammatory cells and eosinophils were quantified. The preoperative CT scans were scored by the staging system of Lund-MacKay.
The grade of the eosinophilic infiltration in the diseased sinus mucosa correlated significantly with the severity of the mucosal inflammation. Allergy or asthma had no effect on the proportion of the eosinophilic infiltrate. The CT scan scores assessed by the Lund-MacKay system correlated significantly with the severity of the inflammatory cellular infiltrate. The correlation between the CT scan scores and the eosinophilic infiltrate of the mucosa was close to significant.
Eosinophilic mucosal inflammation represents the most severe inflammatory changes of the mucosa. Twenty to forty percent of the patients with chronic rhinosinusitis had no eosinophilic inflammation of the mucosa. The CT-staging system of Lund-Mackay correlated with the extent of mucosal inflammation. |
| doi_str_mv | 10.1177/194589240201600301 |
| format | Article |
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Forty-eight pathological sinus mucosa specimens obtained during functional endoscopic sinus surgery were stained by hematoxvlin and eosin. Total inflammatory cells and eosinophils were quantified. The preoperative CT scans were scored by the staging system of Lund-MacKay.
The grade of the eosinophilic infiltration in the diseased sinus mucosa correlated significantly with the severity of the mucosal inflammation. Allergy or asthma had no effect on the proportion of the eosinophilic infiltrate. The CT scan scores assessed by the Lund-MacKay system correlated significantly with the severity of the inflammatory cellular infiltrate. The correlation between the CT scan scores and the eosinophilic infiltrate of the mucosa was close to significant.
Eosinophilic mucosal inflammation represents the most severe inflammatory changes of the mucosa. Twenty to forty percent of the patients with chronic rhinosinusitis had no eosinophilic inflammation of the mucosa. The CT-staging system of Lund-Mackay correlated with the extent of mucosal inflammation.</description><identifier>ISSN: 1050-6586</identifier><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1539-6290</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.1177/194589240201600301</identifier><identifier>PMID: 12141768</identifier><language>eng</language><publisher>United States: SAGE PUBLICATIONS, INC</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Biopsy, Needle ; Chronic Disease ; Confidence Intervals ; Endoscopy - methods ; Eosinophilia - diagnosis ; Eosinophilia - pathology ; Ethmoid Sinus ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Nasal Mucosa - pathology ; Probability ; Retrospective Studies ; Rhinitis - complications ; Rhinitis - pathology ; Rhinitis - surgery ; Sensitivity and Specificity ; Severity of Illness Index ; Sinusitis - complications ; Sinusitis - pathology ; Sinusitis - surgery ; Tomography, X-Ray Computed</subject><ispartof>American journal of rhinology, 2002-05, Vol.16 (3), p.131-134</ispartof><rights>Copyright OceanSide Publications Jun 1, 2002</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-443e5b6337bfe1cabe58cd4fe9e2ea5e4f31be0f09ba1355c9f12ff0789327f63</citedby><cites>FETCH-LOGICAL-c392t-443e5b6337bfe1cabe58cd4fe9e2ea5e4f31be0f09ba1355c9f12ff0789327f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12141768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szucs, Eva</creatorcontrib><creatorcontrib>Ravandi, Saied</creatorcontrib><creatorcontrib>Goossens, Anita</creatorcontrib><creatorcontrib>Beel, Mieke</creatorcontrib><creatorcontrib>Clement, Peter A R</creatorcontrib><title>Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis</title><title>American journal of rhinology</title><addtitle>Am J Rhinol</addtitle><description>The aim of this study was to analyze histopathologically mucosal inflammation in patients with chronic rhinosinusitis. In addition, we assessed tissue eosinophilia in relation to the severity of inflammation and to the computer tomographic (CT) findings.
Forty-eight pathological sinus mucosa specimens obtained during functional endoscopic sinus surgery were stained by hematoxvlin and eosin. Total inflammatory cells and eosinophils were quantified. The preoperative CT scans were scored by the staging system of Lund-MacKay.
The grade of the eosinophilic infiltration in the diseased sinus mucosa correlated significantly with the severity of the mucosal inflammation. Allergy or asthma had no effect on the proportion of the eosinophilic infiltrate. The CT scan scores assessed by the Lund-MacKay system correlated significantly with the severity of the inflammatory cellular infiltrate. The correlation between the CT scan scores and the eosinophilic infiltrate of the mucosa was close to significant.
Eosinophilic mucosal inflammation represents the most severe inflammatory changes of the mucosa. Twenty to forty percent of the patients with chronic rhinosinusitis had no eosinophilic inflammation of the mucosa. The CT-staging system of Lund-Mackay correlated with the extent of mucosal inflammation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biopsy, Needle</subject><subject>Chronic Disease</subject><subject>Confidence Intervals</subject><subject>Endoscopy - methods</subject><subject>Eosinophilia - diagnosis</subject><subject>Eosinophilia - pathology</subject><subject>Ethmoid Sinus</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasal Mucosa - pathology</subject><subject>Probability</subject><subject>Retrospective Studies</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - pathology</subject><subject>Rhinitis - surgery</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - pathology</subject><subject>Sinusitis - surgery</subject><subject>Tomography, X-Ray Computed</subject><issn>1050-6586</issn><issn>1945-8924</issn><issn>1539-6290</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtr3TAQhUVpaR7tH-giiC6yczujh20tS0iaQiCbdG1k3RFWsK0bSQ7k30dJLhTS1cziO2eGcxj7hvADset-olG6N0KBAGwBJOAHdoxamqYVBj7WHTQ0re7bI3aS8z0AdqLHz-wIBSrs2v6YPVzGHNa4n8IcLA8rLxNxKtMSw44vm4vZcrvueCiZJ5ptCXHNU9jzEl_RTI-UQnni0Ve1n-2yvDIvVm5KcQ2Op6leqFe2HErIX9gnb-dMXw_zlP29ury7uG5ubn__ufh10zhpRGmUkqTHVspu9ITOjqR7t1OeDAmympSXOBJ4MKNFqbUzHoX30PVGis638pSdv_nuU3zYKJdhCdnRPNuV4paHrsYHrYIKfn8H3sctrfW3QUjoFfYgKyTeIJdizon8sE9hselpQBhe2hj-b6OKzg7O27jQ7p_kEL98Bs9ahr8</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Szucs, Eva</creator><creator>Ravandi, Saied</creator><creator>Goossens, Anita</creator><creator>Beel, Mieke</creator><creator>Clement, Peter A R</creator><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis</title><author>Szucs, Eva ; Ravandi, Saied ; Goossens, Anita ; Beel, Mieke ; Clement, Peter A R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-443e5b6337bfe1cabe58cd4fe9e2ea5e4f31be0f09ba1355c9f12ff0789327f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biopsy, Needle</topic><topic>Chronic Disease</topic><topic>Confidence Intervals</topic><topic>Endoscopy - methods</topic><topic>Eosinophilia - diagnosis</topic><topic>Eosinophilia - pathology</topic><topic>Ethmoid Sinus</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasal Mucosa - pathology</topic><topic>Probability</topic><topic>Retrospective Studies</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - pathology</topic><topic>Rhinitis - surgery</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - pathology</topic><topic>Sinusitis - surgery</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Szucs, Eva</creatorcontrib><creatorcontrib>Ravandi, Saied</creatorcontrib><creatorcontrib>Goossens, Anita</creatorcontrib><creatorcontrib>Beel, Mieke</creatorcontrib><creatorcontrib>Clement, Peter A R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szucs, Eva</au><au>Ravandi, Saied</au><au>Goossens, Anita</au><au>Beel, Mieke</au><au>Clement, Peter A R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis</atitle><jtitle>American journal of rhinology</jtitle><addtitle>Am J Rhinol</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>16</volume><issue>3</issue><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>1050-6586</issn><issn>1945-8924</issn><eissn>1539-6290</eissn><eissn>1945-8932</eissn><abstract>The aim of this study was to analyze histopathologically mucosal inflammation in patients with chronic rhinosinusitis. In addition, we assessed tissue eosinophilia in relation to the severity of inflammation and to the computer tomographic (CT) findings.
Forty-eight pathological sinus mucosa specimens obtained during functional endoscopic sinus surgery were stained by hematoxvlin and eosin. Total inflammatory cells and eosinophils were quantified. The preoperative CT scans were scored by the staging system of Lund-MacKay.
The grade of the eosinophilic infiltration in the diseased sinus mucosa correlated significantly with the severity of the mucosal inflammation. Allergy or asthma had no effect on the proportion of the eosinophilic infiltrate. The CT scan scores assessed by the Lund-MacKay system correlated significantly with the severity of the inflammatory cellular infiltrate. The correlation between the CT scan scores and the eosinophilic infiltrate of the mucosa was close to significant.
Eosinophilic mucosal inflammation represents the most severe inflammatory changes of the mucosa. Twenty to forty percent of the patients with chronic rhinosinusitis had no eosinophilic inflammation of the mucosa. The CT-staging system of Lund-Mackay correlated with the extent of mucosal inflammation.</abstract><cop>United States</cop><pub>SAGE PUBLICATIONS, INC</pub><pmid>12141768</pmid><doi>10.1177/194589240201600301</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Analysis of Variance Biopsy, Needle Chronic Disease Confidence Intervals Endoscopy - methods Eosinophilia - diagnosis Eosinophilia - pathology Ethmoid Sinus Female Humans Immunohistochemistry Male Middle Aged Nasal Mucosa - pathology Probability Retrospective Studies Rhinitis - complications Rhinitis - pathology Rhinitis - surgery Sensitivity and Specificity Severity of Illness Index Sinusitis - complications Sinusitis - pathology Sinusitis - surgery Tomography, X-Ray Computed |
| title | Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis |
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